Puneeth Guruprasad
@PuneethGuru_
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MS1 @PennMedicine • PhD from @pennbioeng • @GeorgiaTech ChBE • @NSF GRFP
Philadelphia, PA
Joined November 2020
RT @z_chiang: Is it guaranteed that pushing this work forward would make a huge impact? Of course not!. But a healthy research ecosystem mu….
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RT @davidrliu: In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, stud….
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RT @PatriziaPorazzi: Exciting news: EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @Cancer_Cell….
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RT @EvanWeberPhD: Gutting the NIH will kill Americans:. - Patients lose access to lifesaving medicine.- 1000s of lost jobs at NIH and acros….
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Congrats @PatriziaPorazzi and star undergrad Siena Nason (who is going to kill it during her PhD)!.
EZH1/EZH2 inhibition enhances adoptive T cell immunotherapy against multiple cancer models @Cancer_Cell @MarcoRuella.
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RT @IAmDrDex: CAR T cells have shown efficacy in blood cancers and autoimmune disease. In my lab’s recent preprint, we developed CAR Tregs….
www.biorxiv.org
Cardiovascular disease caused by atherosclerosis is responsible for 18 million deaths annually, highlighting a significant need for new medical therapies, especially for patients ineligible for...
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RT @JoeFraietta: Thrilled to share our new paper in @NatureMedicine! We analyzed 783 patients (2,200+ patient-years) receiving lentiviral o….
www.nature.com
Nature Medicine - In an analysis of long-term safety events in 783 patients treated with T cell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration...
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RT @ngaboreden: Our paper is now online @MolecularCell. Architectural protein LDB1 drives enhancer connectivity in….
www.cell.com
Aboreden et al. show that the architectural protein LDB1 broadly establishes regulatory networks via long-range loop formation. Contacts involving LDB1 can form in a manner dependent on or independ...
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Wild experience to have seen our story shared at the #ASH24 Plenary in San Diego by my wonderful co-lead @Shan_Liu_ ! Looking forward to further proving that we can enhance cancer treatment by modulating readily-actionable patient lifestyle factors.
A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Session today. @MarcoRuella @MaayanLevy_Lab @PuneethGuru_
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RT @Shan_Liu_: Huge honor to present our work on enhancing CAR T cell function via dietary intervention in the Plenary Session at #ASH2024!….
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RT @AlbertoCarturan: Grateful to #ASH2024 for the chance to present our work on overcoming the absence of CD2:CD58 co-stimulation using an….
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RT @PennMedicine: A simple dietary supplement may provide a new approach to boost #CART cell function – hear more in the #ASH24 Plenary Ses….
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RT @PennMedicine: Learn more about the exciting advances in blood cancer and benign hematology research that Penn Medicine and @PennCancer….
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RT @_ruchipatel: Looking forward to discussing our latest work on CD5 next week! Register here to join: https://t.c….
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RT @anandbmdphd: Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy….
www.nature.com
Nature Medicine - In a phase 1 trial followed by translational analyses, patients with acute myeloid leukemia (AML) treated with chimeric antigen receptor (CAR) T cell therapy targeting CD123...
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RT @ngaboreden: Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks an….
www.biorxiv.org
How specific enhancer-promoter pairing is established is still mostly unclear. Besides the CTCF/cohesin machinery, only a few nuclear factors have been studied for a direct role in physically...
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🥳🎉🥳🎉.
Our paper is out in Science Immunology! As you can see from the author list, this was truly a team effort and I am so grateful for everyone’s support, especially @MarcoRuella for his mentorship. Next stop: continuing my thesis work into clinical translation at Vittoria Bio 🙂.
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RT @MarcoRuella: Congrats to the now Dr. @_ruchipatel.for the publication of her PhD thesis in @SciImmunology. We show here that CD5 deleti….
www.science.org
Deleting CD5 with CRISPR-Cas9 enhances T cell activation and proliferation, boosting their antitumor effects in multiple tumor models.
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RT @jrotwitguez: It’s finally out! 🥳 Today @cellcellpress we report non-mineral fossils of ancient chromosomes in skin from a woolly mammot….
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