Maayan Levy
@MaayanLevy_Lab
Followers
1,917
Following
318
Media
16
Statuses
332
Research lab @Penn @PennMicro , studying metabolites and their impact on physiology and disease
Joined February 2018
Don't wanna be here?
Send us removal request.
Explore trending content on Musk Viewer
Israel
• 1495769 Tweets
#Eurovision2024
• 1416652 Tweets
América
• 471050 Tweets
New Jersey
• 203960 Tweets
Switzerland
• 155380 Tweets
#母の日
• 133878 Tweets
Nemo
• 117923 Tweets
Suiza
• 62539 Tweets
ヴィクトリアマイル
• 56087 Tweets
#仮面ライダーガッチャード
• 51581 Tweets
Croatia
• 50824 Tweets
#UFCStLouis
• 43004 Tweets
Mavs
• 33841 Tweets
Barco
• 29474 Tweets
#ブンブンジャー
• 27629 Tweets
DAIGO
• 25956 Tweets
カーネーション
• 25313 Tweets
Igor
• 22916 Tweets
ストフェス
• 21395 Tweets
Pachuca
• 18818 Tweets
カグヤ様
• 17902 Tweets
Canes
• 16939 Tweets
Saint MSG Insan
• 13302 Tweets
Buckley
• 10299 Tweets
Pinned Tweet
We are excited to share our new work
@CellCellPress
, led by Andie Wong, in collaboration with the groups of Ben Abramoff, Sara Cherry, and
@ThaissLab
, uncovering a multi-organ pathway with important implications for the pathogenesis of
#LongCOVID
. (1/10)
87
792
2K
We are excited to share our new work
@Nature
with
@ThaissLab
, uncovering the impact of ketogenic diet and beta-hydroxybutyrate on colorectal cancer, led by
@OxDmitrieva
. (1/7)
45
204
878
Our findings suggest that several of the current hypotheses for the pathophysiology of
#LongCOVID
(viral reservoir, persistent inflammation, hypercoagulability, vagus nerve dysfunction) might be linked by a single pathway that is connected by serotonin reduction. (8/10)
19
175
665
We hope that our discovery will inspire clinical studies that use these insights to develop new tools for the diagnosis, monitoring, and treatment of
#LongCOVID
. They are so urgently needed. (9/10)
6
20
286
How do viral infections result in serotonin reduction? We found that type I interferon signaling was required, which is interesting in light of recent reports suggesting that viral persistence and sustained elevation of interferons are characteristic of
#LongCOVID
. (5/10)
5
56
281
What are the consequences of serotonin reduction? We found evidence for reduced activation of the vagus nerve, resulting in neurocognitive manifestations, such as impaired memory. Interventions that restored serotonin levels or vagal activity prevented memory impairment. (7/10)
11
57
274
We assessed the metabolite profile of individuals with
#LongCOVID
and identified
#serotonin
as a molecule whose abundance is reduced both during acute COVID-19 and in individuals with multiple long-term symptoms. (3/10)
5
47
248
@CellCellPress
@ThaissLab
We followed a cohort of more than 1,500 individuals with
#LongCOVID
and characterized their spectrum of symptoms. We then asked whether we could identify biomarkers that distinguish individuals with Long COVID from fully recovered individuals. (2/10)
3
34
239
The phenomenon of serotonin reduction was not unique to SARS-CoV-2 infection, since we also observed it in humans and mice acutely or chronically infected with other viruses, and even in mice treated with the viral RNA mimetic poly(I:C). (4/10)
2
41
235
How do interferons drive serotonin reduction? Three mechanisms: (1) reduced intestinal uptake of tryptophan, the biosynthetic precursor of serotonin; (2) reduced counts of platelets, which carry serotonin in the circulation; (3) enhanced enzymatic turnover of serotonin. (6/10)
5
34
223
Many thanks to all our collaborators
@PennMicro
,
@PennPathLabMed
,
@PennMedicine
,
@UPenn_I3H
, and
@UCSF
, including
@EJohnWherry
,
@nualameyer
,
@MichaelPelusoMD
,
@DeeksSteven
, and many more! (10/10)
18
9
203
Really excited to be one of the 2023
@BWFPATH
Investigators and to join the BWF family! Thank you for supporting our work
@BWFUND
!
Congratulations to the 2023 Investigators in the Pathogenesis of Infectious Disease
@Mari_Byndloss
@yiweichang
@UTSWedu
@HarrisTryonLab
@MaayanLevy_Lab
@DrShrutiNaik
@ReboldiLab
@TuftsMedSchool
@TuftsUniversity
@YanBiofilmLab
#bwfpath
18
38
207
14
1
58
This discovery might provide us with a powerful tool in the fight against colorectal cancer. However, before making any recommendations about
#ketogenic
#diet
and BHB for prevention or treatment, we need to wait for the results of clinical trials. Stay tuned! (7/7)
4
2
35
We screened different diets for their potential to inhibit the development of colorectal cancer, and found that ketogenic diets had the most potent effect, in collaboration with
@SGrivennikov
. (2/7)
1
4
30
Ketogenic diets induce hepatic ketogenesis, similar to long periods of
#fasting
. We found that the ketone body beta-hydroxybutyrate (BHB) was similarly protective against colorectal cancer as ketogenic diet. (3/7)
1
2
27
First lab event in many months, together with
@ThaissLab
. Celebrated being able to finally be together and the new positions of Oxana, Lila, Angel and Aleks!
1
3
26
Congrats to Markus
@KM_Schneider1
, Niklas
@NiklasBlank4
, Yelina
@AlvarezYelina
and all the co-authors!
We are excited to share our new study
@CellCellPress
with
@MaayanLevy_Lab
, led by
@KM_Schneider1
,
@NiklasBlank4
, and
@AlvarezYelina
, uncovering a brain-gut pathway by which psychological stress exacerbates intestinal inflammation. (1/10)
16
124
382
1
4
25
The BHB-Hopx pathway also suppresses the growth of human colorectal cancer cells, which we found together with Bryson Katona, Chris Lengner,
@KHamiltonPhD
, and
@beyazlab
. (6/7)
3
3
24
How do ketogenic diets and BHB inhibit the growth of colorectal cancer? We teamed up with
@jonepstein1
and Raj Jain to discover that the anti-cancer effect was mediated by the transcriptional regulator Hopx. (4/7)
1
3
21
How is Hopx regulated by ketogenic diet and BHB? In collaboration with
@KlausKaestner
and
@berger_lab
, we ruled out epigenetic effects. A CRISPR screen showed that the regulation of Hopx and its tumor-inhibitory effect was mediated by the BHB receptor GPR109A/HCAR2. (5/7)
1
2
17
Looking forward to teaching in the new
@HMS_ExecEd
program "The Microbiome: Emerging Opportunities for Biopharma" in April. Learn more:
0
4
7
The pandemic and the female academic
0
2
8
A new study from Nilam Mangalmurti
@PennMedicine
describes an exiting new role of red blood cells as innate immune sentinels.
Red Blood Cells Function as DNA Sensors | bioRxiv
0
1
6
Diversity of ribosomes in the human brain and gut? A very interesting work by Daphna and her team where they discover different *human* ribosomal rRNA variants across human tissues and cancers!
0
2
6
Day 1:7 photos of my life. Rules: no people, no explanations, and challenge one new person each day.
I was challenged by
@FlyByVirus
0
0
4
@Elinav_Lab
@FluhrLeviel
@uria_mor
@HagitShapiro
@Nature
Congratulations 🎉 another great story from the Elinav Lab!
0
1
4
@JoelBabdor
@SunnyShinLab
@PennMedicine
@PennMicro
@PennSysPharmATT
@Penn
@Penn_IFI
Congratulations and welcome to Penn!!
1
0
3
0
0
3
In silico decontamination method for microbiome data. Congratulations!!
@tkorem
Imagine this:
You just got new microbiome data, and find that your negative controls have reads from 3 different microbes in equal abundances. In your patient samples, however, you only detect one of them (in high enough abundance). Is it a contaminant?
4
48
207
1
0
3
0
0
3
1
1
2
1
0
1
0
0
1