Anand Bhagwat, MD, PhD
@anandbmdphd
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Oncologist @ChildrensPhila. In @GillSaar lab @Penn, formerly @ChrisVakoc lab @CSHL. Also an avid eater and a dad.
Philadelphia, PA
Joined March 2023
Tremendously proud to share my fellowship work, online today in @NatureMedicine. We tried to understand why CAR T therapy for AML doesn't work as well as we hoped it would, and how we can solve that. 👇🧵1/10.@PennMedicine @CHOP_Research @GillSaar
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Unbelievably honored to have received a career award from @BWFUND. Hard to express how meaningful this support is in times like today. Also hard to express enough gratitude to my family, to my mentors, and to the patients we do this for.
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RT @wokesalaryman: The year my son got cancer. DISCLAIMER: THIS IS A PRO BONO PIECE WRITTEN IN COLLABORATION WITH THE CHILDREN'S CANCER FO….
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RT @DrSamelsonJones: #Pediatric Scientist Development Program grant was terminated. The federal grant that has sustained PSDP for over 35….
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RT @isaiah_bb: Sometimes when two sides appear on “the extremes” of an issue, it’s because one side is right and the other side is made up….
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RT @isaiah_bb: Yeah I mean, this is what people from Guatemala and El Salvador have been experiencing for the last 20 years and if it only….
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RT @Acyn: Clark: Elon Musk makes more in one day than NIH spends all year on childhood cancer research. But that hasn't stopped him from st….
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RT @RepAuchincloss: Basic science is inspired by curiosity, accountable to evidence, and subject to peer review. Politics should have no ro….
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RT @EvanWeberPhD: Gutting the NIH will kill Americans:. - Patients lose access to lifesaving medicine.- 1000s of lost jobs at NIH and acros….
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RT @_TheTransmitter: A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable futur….
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RT @luckytran: The entire archive of all CDC datasets uploaded before January 28th, 2025 has been backed up on Internet Archive. Incredibl….
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RT @nickmmark: This just gets worse & worse. Under Trump’s new policy, cancer researchers at the NIH aren’t allowed to buy reagents, effec….
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RT @NewsfromScience: “The impact of the collective executive orders and directives appears devastating.”
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In clinical practice, we are always learning from our patients. I most of all want to thank the patients who participated in this study. I also want to thank all the co-authors, mentors, and especially my family, who supported this work in so many ways. -10-.
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Why didn't we see this coming? Well these cytokines don't seem to help B-ALL, for example. They're myeloid-supporting cytokines, so this makes sense. Could other cytokines in CRS support B-ALL and contribute to CART19 treatment failures? Why not? 9/
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It's worth noting that CART cells are still functional and still eliminate AML if numbers work in their favor. The first wave seems to kill AML blasts, but then the resulting cytokines make the remainder resistant. Poor responses or faster relapses result. 8/
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Of course it remains to be seen whether this will work in people 🤞, but I'm excited to see how this combination therapy fares as we re-open this trial. We think this axis of resistance will apply generally to AML immunotherapies, so we need compelling approaches to block it. 7/.
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Luckily we can block JAK/STAT signaling with ruxolitinib. To our delight, this indeed can reverse cytokine-mediated resistance and restore CART123 killing of primary AML. We can block BCL2 and restore killing that way, too. CART doesn't care about venetoclax–more to come. 6/
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