James Hodgkinson-Bean
@JamesBeanBio
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Post-doctoral researcher at the University of Copenhagen. Interests in bacteriophage research and cryo-EM. views are my own.
Copenhagen, Denmark
Joined May 2022
Most recent paper out now at science advances. We investigated a BASEL phage belonging to the felixounavirus genus and discovered evolutionary relationships with distantly related phages. Collaborative work between @HiCryoEM and @mihnea_bostina
https://t.co/JGpl5MuNoV
science.org
Cryo-EM of phage Bas63 reveals unique capsid and tail features, offering insights into Felixounavirus evolution and architecture.
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Excited to see our work published in @ScienceAdvances! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here:
science.org
RBPseg enables accurate modeling of tail fiber structure, providing the first comprehensive tail fiber structure atlas.
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Exited to share our preprint on the structure of a Salmonella contractile injection system 🥳 Wonderful work by first author @Rooshanie Ejaz and @CloudyKielkopf, @freddie__martin, @HangryHobbit, @RebrovaEva, great collab with @Salmo_Lab
@UCPH_CPR #cryoem
https://t.co/rKTXTFPFgj
biorxiv.org
Extracellular contractile injection systems (eCISs) are phage-derived nanomachines used by bacteria to deliver effectors into target cells. Well-studied examples include the Photorhabdus asymbiotica...
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Congratulations to first author Leyre Arraiza and all co-authors for our preprint on the structure of a PVC of Photorhabdus luminescens in extended and contracted states! @UCPH_CPR #cryoEM @cryoEM_Papers
biorxiv.org
Contractile injection systems (CISs) are phage-tail-like nanosyringes that mediate bacterial interactions by puncturing target cell membranes. Within these systems, Photorhabdus Virulence Cassettes...
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This is jaw dropping level stuff!
Excited to share our pre-print on the molecular architecture of heterochromatin in human cells🧬🔬 w/ @jpkreysing, Johannes Betz,Turoňová lab, @MarinaLusic, Hummer lab, @Beck_Laboratory, @MPIbp 🔗 Preprint here: https://t.co/0tTxZcu0Vz
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Excited to announce that collaborative work between the Bostina lab (@mihnea_bostina) and PHI lab (@PeterFineran) at @otago and the Wolf lab (@HiCryoEM) at @OISTedu, has been published in Nature Communications. Congratulations all :) https://t.co/u1nIrZfRTq
nature.com
Nature Communications - The cryo-EM structure of phage φTE is presented, revealing a distinct neck topology, tail sheath baseplate organization and oligomeric state of the tape measure...
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Very stoked to finally have my first co-first author manuscript published with PNAS nexus. We describe the phiM1 virion structure with a focus on the ejectosome, showing considerable structural variance relative to phage t7. https://t.co/5zMMUvJ41r
academic.oup.com
Abstract. Podophages that infect gram-negative bacteria, such as Pectobacterium pathogen ΦM1, encode tail assemblies too short to extend across the complex
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Late post: Had the absolute mega opportunity to attend the 2024 FASEB conference on Virus Structure and Assembly. I presented our upcoming publication, and was fortunate to be awarded travel scholarship funding in the closing ceremonies. Big thanks to the FASEB organizers :)
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Excited to have created my first GitHub repository today. My script generates a spectrum of capsid vertex coordinates in @UCSFChimeraX , and prints their coordinates for use in asymmetric reconstruction workflows. I2 symmetry is currently required. https://t.co/QHroBcc06Z
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Delayed Hanmer Springs @nzsbmb conference post. Was absolutely delighted with last weeks talks and with the opportunity to present one of our exciting recent phage projects.
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Excited for our upcoming Phage Bites session that will be running online next week! See our student/ECR presentations that will be followed by a panel discussion of 'Standardisation in Phage Therapy' Aus/NZ - There is still time to register to attend!: https://t.co/ceo7WB3SAO
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