Nathan Zangger
@NathanZangger
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PhD Candidate @ETH @LabOxenius Investigating viral infections, with a focus on CMV | Passionate about spatial immunology and cellular microenvironments
Joined January 2020
Congrats to Josua!! And for me a first 2nd authorship and modest contribution to the scientific world, hopefully others to come 🙏🏽
Kicking off the week with Josua Oderbolz's paper on @biorxivpreprint! Collaborative work with the Graw lab @UniHeidelberg revealing new insights into the spatiotemporal dynamic of #MCMV infection and associated immune response. Well done! https://t.co/2HX9442ase
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"Fundamental and applied research are both necessary for innovation in science and industry" We're extremely proud to share the news of Annette's appointment as ETH Vice President for Research 🎉
Annette Oxenius has been appointed ETH Vice President for Research, effective August 1, 2025. The 56-year-old Swiss immunologist and professor will lead research development and promotion at ETH Zurich. Read more:
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Excited to share our new paper in @JExpMed 🎉 We show that NK cells use autocrine TGF-β1 signalling to establish tissue residency, form a highly cytotoxic subset, and protect the tissue against viral persistence.
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The wait is over!! We are thrilled to announce that we have chosen Spatial Proteomics as 2024’s Method of the Year! 🥳 For more on Spatial Proteomics and a road map to this special issue, please see this month’s Editorial or read on in this thread. https://t.co/phXooJzJda
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Excited to share our contribution to the groundbreaking work by @BenHale and the @SnijderLab recently published in @ScienceMagazine! 🎉 Discover the unexpected link between T cell architecture and their fate🔬More on stripy T cells: https://t.co/Sbe5Fb78pi
#TCells @Microbio_ETH
science.org
After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic...
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#Tweetorial for our paper in @ScienceMagazine It's still largely unknown how naïve T cells decide to become either effector or memory T cells during viral infection. We show that these decisions are built into the cellular architecture of our T cells. 1/9 https://t.co/yOQgVaPgot
science.org
After antigen stimulation, naïve T cells display reproducible population-level responses, which arise from individual T cells pursuing specific differentiation trajectories. However, cell-intrinsic...
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Our big story on the importance of "stripy" T cells in antigen response, which started as a MSc Thesis 6 years ago, has finally made its way out in @ScienceMagazine! 🤩 Massive congrats to @BenHale95 & thanks to all collaborators particularly @LabOxenius & @blutspendesrk 🥰
Out now @ScienceMagazine: @BenHalePhD, @BerendSnijder & colleagues report that the internal architecture of T cells at the moment they are activated can influence their fate in response to antigen. 🔗 https://t.co/yMHMt6Ee0l
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🎉 Thrilled to share our latest preprint! We conducted a large-scale screen with ~20,000 human retinal organoids, testing 2,707 compounds to counter cone-degeneration. Thanks to @IOB_Roska and my collaborators. 🧵👇
biorxiv.org
Human organoids that mirror their corresponding organs in cell-type diversity present an opportunity to perform large-scale screens for compounds that protect disease-affected or damage healthy cell...
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Big anniversary of over 20 years of science in @LabOxenius. Very delighted to celebrate with many past and current lab members at beautiful #Uetliberg - An exciting day of science and a revival of old memories and lasting relationships 🍾 Looking forward to many more years!
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Thrilled to share our newest publication by @FGrabnitz and colleagues in @CellReports showing that asymmetric cell division safeguards memory CD8 T cell development upon strong TCR stimulation. 🥳🔬 Congrats Fabienne! https://t.co/85tGqyH8uZ
cell.com
Memory potential of CD8 T cells decreases with increasing TCR signal strength. Gräbnitz et al. show that on strong TCR stimulation, ACD-derived single cells give rise to mixed-fate colonies, whereas...
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All Editors of NeuroImage (IF = 7) resigned because Elsevier didn’t want to reduce the hefty publication fee (it’s $3,450 !!!). And then started their OWN journal! Just a reminder - the profit margin for academic publishing often reaches 40% (while for non-academic - 15%).
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Extremely proud to present my new paper https://t.co/IlTizJ5Iy9 done in collaboration with the amazing Ruben Casanova @uria_mor. 1/4
biorxiv.org
The rapid development of multiplexed imaging technologies has enabled the spatial cartography of various healthy and tumor tissues. However, the lack of adequate statistical models has hampered the...
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Really proud to see my recent work highlighted by @naturemethods : https://t.co/kk8PHs2Xi1 !
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Extremely proud to have my first postdoc paper out in @naturemethods : https://t.co/g6xSWp2r0Z !
nature.com
Nature Methods - A statistical approach for optimal design of multiplexed imaging studies has been developed. It determines experimental parameters that facilitate cell phenotype identification.
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Annette Oxenius from @LabOxenius, an institute of @Microbio_ETH, was awarded the Cloëtta Prize for her outstanding research work in the field of infection immunology. Congratulations! https://t.co/922e9fLvkE
#Immunology #CloettaPrize
ethz.ch
Together with her group, Annette Oxenius conducts research on the fundamental mechanisms of the body’s own immune cells as they react to viral infections. The immunologist has now been honoured with...
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Yet one week later, still processing all the inspiring work presented @ImmunOctober🤯 Great event to catch up with all the experts in #Immunology research and a pleasure to share our research and attend the talk of our former lab member @nanaborsa. Many thanks to the organizers!
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Excited to share our paper on ILC1 and NK cell ontogeny. Embryonic ILC1s persist and mature in the liver, forming cytotoxic effectors - postnatal wave brings first NK cells and more ILC1s. Now in @SciImmunology
https://t.co/eaW5zBNTqs
science.org
Characterization of murine group 1 ILC development reveals a layered ontogeny influenced by tissue and age.
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Our new review ‘Stem-like’ precursors are the fount to sustain persistent CD8+ T cell responses” is out @NatImmunol. Great team effort with Dietmar Zehn @LabOxenius Robert Thimme @teximmed2 and Gustavo Almeida
nature.com
Nature Immunology - Zehn and colleagues review the cellular fates and precursor trajectories that allow antigen-specific CD8+ T cells to persist in the face of chronic infection and cancer.
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CMV infection has a profound impact on our adaptive immunity. In 2 recent reviews, @NathanZangger and Prof. Oxenius discuss the particular features of T cells during infection (1/2): https://t.co/CrVEkP0F8v
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Happy to be part of this formidable initiative! Tune in on Wednesday's #globalimmuno talk at 6pm CET to Prof. Oxenius's talk. Many thanks to the organizers!
Looking forward to our next #globalimmuno talk this Wednesday March 2 at 9am PST noon EST 5pm GMT by Dr. Annette Oxenius. Title: Regulation of adaptive immunity during (chronic) viral infection LINK: https://t.co/2Tdtm2QoUL
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Extremely happy and proud to present my first PostDoc paper in the @BodenmillerLab, done in collaboration with the amazing @DanielS33860077, Stefanie Engler, Clive Wasserfall and Bernd Bodenmiller : https://t.co/XSmWpsV1ry 1/7
biorxiv.org
Recent advances in multiplexed imaging methods allow simultaneous detection of dozens of proteins and hundreds of RNAs enabling deep spatial characterization of both healthy and diseased tissues....
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