New #JITC short report: Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy https://t.co/p7uihdWuf5 @MarkLong_PhD @dkmlv1 @lab_ito

Reporting another impactful study in collaboration with the fantastic @lab_ito. Using single-cell reference mapping we reveal the heterogeneity of iPSC derived DCs. Improving functional cDC generation from iPSCs could be a major boost for autologous DC based immunotherapy.

I take solace in knowing deep down that the @BuffaloBills would have lost the super bowl on a last second 75 yard field goal that bounced off a defenders head in the end zone anyways.

@CIR_AACR #OnlineFirst: Tumor-associated self-antigens show limited efficacy as therapeutic anticancer vaccines. A new method to systemically ID short CD8+ #Tcell #mimitopes that better inhibit tumor growth vs. the native epitope is presented. @MarkLong_PhD @jflovell 🧵🧵👇👇

@MorayCampbell @SmiragliaLab Shout out to the ever impressive @JacobiJustine for providing the final push to make this a reality. @CellReports

Proud of this one, contributions spanning my pre-doc, post-doc and junior faculty appointments, a true representation of my journey through this thing called academia. Bench, mouse, bioinformatics. Incredible mentorship from @MorayCampbell and @SmiragliaLab along the way.

Product of a continuing collaboration with my postdoc mentor @SmiragliaLab (and remnants of my days at the bench!) linking DNA methylation dynamics in normal prostate epithelial cells to regions of aberrant hypermethylation in prostate cancer.

tidyseurat: Interfacing Seurat with the #Rstats tidyverse https://t.co/84TM9ZqpQ8 https://t.co/RAJwBGh6K5 https://t.co/jBK0co8tAm

Our review on #RNA dysregulation as source of cancer #immunotherapy targets is out @TrendsinPharma! This work was supported by NCI @IOTNmoonshot @parkerici, with colleagues @CHOP_Research @UCLAstemcell @RoswellPark. Cover art by @robwang_916 of @UPennGCB! https://t.co/tHdaMDxvCx

I was falling asleep at orientation when @MorayCampbell walked in and asked if anyone wanted to go to @uni_lu and @VUamsterdam to study something called 'systems biology'. Truly a life changing experience, I could not have imagined where #CanSys and @RoswellPark would take me!

Wonderful study led by Shabnam Shalapour and Michael Karin, revealing epigenetic regulation of MHC-I AgPP augmented by low-dose chemotherapy. Honored to be a part of this exciting work, a collaboration fostered by @IOTNmoonshot. @RoswellPark @UCSDMedSchool https://t.co/IF3dZ8RBSS

🤣 Wait for it... TT @bri_xu https://t.co/FXAfpwBOPz #datascience ht @kierisi

As part of @_hubmap we're excited to release a web app to automatically map scRNA-seq datasets to four organs, with more to come! Just upload a gene expression matrix and hit 'Map cells to reference' Check it out, run a demo, and map your own datasets: https://t.co/6Cvnej2zaP

Interested in single cell genomics but need help getting started? Check out my lab's Single Cell Genomics Day on March 26. Talks will feature recent exciting computational and experimental advances and will be livestreamed at https://t.co/zG98gkckMU. Please RT/spread the word!

Prediction of neo-epitope immunogenicity reveals TCR recognition determinants and provides insight into immunoediting: Cell Reports Medicine

Seurat v4 is now available on CRAN! V4 includes tools for single-cell analysis of multimodal, spatial, and pooled CRISPR screen datasets. We also have an updated website with new vignettes, improved docs, and tips for analyzing and integrating many cells:

Very excited to share a cool project that I was privileged to coordinate with the awesome @safiadanovi — a timeline of key basic, translational and clinical research advances in the last 20 years of #cancer research! @NatureMedicine @NatureGenetics

Very nice overview: Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data.

All 188 plots contained in "A #ggplot2 Tutorial for Beautiful Plotting in #Rstats" 🔖 The full tutorial here: https://t.co/cPUwZUMjg0 🛠️ All codes here: https://t.co/p89AYKiQsO