IOTN Moonshot
@IOTNmoonshot
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Official X account of the NCI Immuno-Oncology Translational Network (IOTN).
Joined October 2018
The Immuno-Oncology Translational Network (IOTN) of @theNCI is a Cancer Moonshot Initiative to improve immunotherapy outcomes for both “hot” and “cold” cancers - and to prevent cancers before they occur. Read more at https://t.co/OstP8iyT6i and https://t.co/Hwk1z0Luy5
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🚨 In light of the #NobelPrize recognizing discoveries in peripheral immune tolerance, our article "Regulatory T cells in the tumour microenvironment" is now free to read. Discover how #Tregs shape cancer immunity 📖 👇 https://t.co/KL71f2Sh0c
nature.com
Nature Reviews Cancer - This Review by Imianowski et al. outlines the various contributions that regulatory T cells, present in the tumour microenvironment, make towards tumour progression and...
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The latest issue of the @theNCI #ARTNet Newsletter is out! It features highlights and reports from the ARTNet Scientific Retreat held in September 2025, along with updates on network progress and ongoing initiatives. https://t.co/dcEP37q3gm
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Register now for the @sitcancer-@theNCI Computational IO Series: Liquid Biopsy Approaches for Cancer Diagnosis and Monitoring: Computational Science in Immuno-oncology 🔗 https://t.co/RSNwnYK2XW
@RiyueSunnyBao
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#REVIEW 🚨 Antibody–drug conjugates are rapidly expanding in clinical cancer treatment and in preclinical development. In this Review, Thurber&Co highlight the molecular interactions and immune effects driving #ADC efficacy and toxicity. 📖⬇️ https://t.co/wS841UOGhB
nature.com
Nature Reviews Cancer - Antibody–drug conjugates are rapidly expanding both in the clinical treatment of cancer and in preclinical development. In this Review, Zippelius et al. highlight the...
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The 2025 medicine laureates identified the immune system’s security guards, regulatory T cells, which prevent immune cells from attacking our own body. The fundamental knowledge that researchers have gained through the discovery of regulatory T cells and their importance for
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Our immune system is an evolutionary masterpiece. Every day it protects us from the thousands of different viruses, bacteria and other microbes that attempt to invade our bodies. Without a functioning immune system, we would not survive. One of the immune system’s marvels is its
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BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”
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A new Review explores the mechanisms underlying inhibitory immune checkpoints and suggests that a deeper understanding of these nuances could improve checkpoint-based cancer #immunotherapies. Learn more in Science #Immunology: https://t.co/5oF5YnWDKK
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Congrats to DrCongFu ! Wonderful to collaborate with @MangusoLab on in vivo CRISPR of epigenetic targets study in #HNSCC models @NatureComms @kathleenbyates @IOTNmoonshot Thanks also to @SilvioGutkind @rsaddawi !!
nature.com
Nature Communications - UCHL5 is a deubiquitinating enzyme that cleaves Lys-48-linked polyubiquitin chains. Here, the authors discover through in-vivo CRISPR-Cas9 screens that Uchl5 is involved in...
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IRG1 catalyzed energy metabolite itaconic acid restrains type I interferon-dependent immune responses by alkylation of TBK1
cell.com
Chai et al. reveal a mechanism linking energy metabolism to the inhibition of TBK1-induced type I IFN responses via the IRG1-itaconic acid axis and develop itaconic acid-based TBK1 inhibitors ITA-5...
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New #IOTNPublication in @CellCellPress from Dr. Michael Demetriou & team @UCIrvine: Safe immunosuppression-resistant pan-cancer immunotherapeutics by velcro-like density-dependent targeting of tumor-associated carbohydrate antigens https://t.co/fA4E2olF6A A summary of the
cell.com
Targeting tumor-associated carbohydrate antigens, the most abundant and widespread cancer antigens known, via “velcro-like” binding of lectins allows immunosuppression-resistant pan-cancer killing...
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Join us for the NCI/NIA Virtual Workshop on Immune Aging & Cancer Therapy (Nov 12–13, 2025)! https://t.co/AvKpciS3P0 Topics: Immune aging & cancer Immunotherapy response & resistance Therapy toxicity & challenges Free & open to the public—register here:
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#ScienceSaturday ❓ Why do some cancers resist immunotherapy? ➡️ A recent study in Nature found that certain cancers can “trick” the body’s immune system. They do this by changing how cells in the bone marrow develop. These changes cause more immune cells called macrophages to
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Online Now: Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://t.co/SGIMSvR2AW
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A Science #Immunology Review highlights the role of #DendriticCells in shaping T cell antitumor responses and explores how this interplay could be harnessed for cancer #vaccines. Learn more on #WorldCancerResearchDay: https://t.co/e4KsjJoD1r
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Transcriptional control of natural killer cell antitumor activity https://t.co/JqY00uCR6J
#immunology
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New #JITC article: Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancer https://t.co/eFJKBe8U75
@OlivaM_Onc @petra_jankowska
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Nature research paper: Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis https://t.co/GsmHKigpRz
nature.com
Nature - Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses...
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