Luiza Moore
@Luiza_Moore
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Senior Director, Global Oncology Diagnostics @AstraZeneca & Pathologist @CUH_NHS | PhD & post-doc @sangerinstitute | cancer | genomics | computational pathology
Cambridge, UK
Joined October 2015
Absolutely delighted to see our two papers finally published in @Nature! Massive thank you & congratulations to everyone who have helped us with these studies! https://t.co/IKTR626hiI
https://t.co/VQg9p43yHJ
After many years and a real journey, we are excited to share our preprint on mutations in human cells! We studied multiple samples from the same individuals to explore mutational landscapes across cells and tissues. #Panbodymap
https://t.co/b6lJHmd8mu Thread [1/10] 👇👇👇
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So proud of @JeanEAbraham722 and her team for this study that is all over the news today! Catch the BBC1 coverage of these amazing clinical trial results for patients with BRCA positive breast cancer. Thank you for all you do for patients! @CRUKCamBreast
The results of the PARTNER Trial Hereditary BRCA 1 and 2 related breast cancer cohort are now out in @NatureComms 👉🏼 https://t.co/lMHPRtsmir Read alongside the TNBC results for the full story https://t.co/LFTv80C16F. Thanks to the amazing patients that took part.
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A huge thank you to all patients, all the NHS hospital trusts, and trials teams that took part in the PARTNER trial @CUH_NHS; @CRUKCamBreast; @CRUKCamCentre; @Cambridge_Uni; @CambridgeBRC Thanks to @NatureComms and their editorial team!
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Catch our @CRUKCamBreast Co-lead, Prof Jean Abraham, talking more about this research and new treatment approach on BBC Radio 4 PM from 5pm and BBC News at Six this evening. https://t.co/P7l0RFTFd0
bbc.co.uk
Treating patients with a drug before surgery greatly reduced the chances of the cancer coming back, a small trial found.
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This new paper @Nature today on the genesis and evolution of stomach cancer goes against the alt-model https://t.co/hsjIMmVKBs
https://t.co/IABPCWKgK5
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The stomach is an organ unique in its function, environment and exposures. How does this affect the mutations that normal cells in the stomach acquire? What does this reveal about the origins of stomach cancer? These questions and more in our Nature paper: https://t.co/n7vcJq0ApW
nature.com
Nature - Whole-gene sequencing of microdissected gastric glands from individuals with and without gastric cancer reveals distinct patterns of somatic mutations and provides insights into influences...
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Beautiful work from @jyoti_nangalia @PeggyGoodell Peter Campbell and team 👏
How blood ages - A curious case of mice and men. Our latest study @Nature published today. Biological processes such as DNA mutagenesis often scale to animal time. Blood stem cells have special evolutionary protection against this. 👉🏽 https://t.co/SoVUzbAyDT
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Finally out in @NatureProtocols : our group's workflows for end to end computational pathology. Compatible with UNI and other foundation models. Led by @ElNahhasOSM from @katherlab journal link: https://t.co/oa2HFvH4Kg full text: https://t.co/8zKLRNAgjB
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New article from @katherlab in @NatureMedicine: large language models for interoperability in healthcare 👇
In the era of large language models: "The extensive efforts previously required to standardize and make coding systems and ontologies interoperable for traditional computing are no longer necessary." https://t.co/lUZsgF77kz by @jnkath @DanielTruhn @Dykex6 @IsabellaWies
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Very excited to share our latest preprint on somatic mutations in the normal stomach. We found many surprises, incl. hypermutant glands, recurrent somatic trisomies and a unique landscape of driver mutations. Thread below!
biorxiv.org
The landscapes of somatic mutation in normal cells inform on the processes of mutation and selection operative throughout life, permitting insight into normal ageing and the earliest stages of cancer...
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Thrilled to announce our collaboration with @CytedHealth and Cancer Research UK to scale early detection of esophageal cancer with AI.
Microsoft Research worked with Cyted & Cancer Research UK to build AI models that improve early detection of esophageal cancer—the 6th most common cause of cancer deaths. The models reduce pathologists’ workload by up to 63% and could save countless lives: https://t.co/dBYimBmvEh
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Join a great team in Liverpool - strong record of being very friendly!! Job vacancy: Consultant Ophthalmic Pathologist, Liverpool University Hospitals NHS Foundation Trust, Liverpool | https://t.co/m5eNDxiwzo
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Profound 🧡
Joseph Campbell said, “If you can see your whole life’s path laid out, then it’s not your life’s path.” If you’re not careful as a parent, your past will dictate your child’s future. Instead of encouraging exploration. you push your kids to a predefined destination. All
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Absolutely! Physician-scientists and scientists with parenting responsibilities 👇👇
Grateful and proud to speak about a topic near and dear to my heart alongside Ayaka Sugiura (@VanderbiltMSTP), @taliaswartz, and other inspiring women a in @NatureMedicine Comment piece today! @A_P_S_A #physicianscientists #doubledocs
https://t.co/7YstR7eyuB
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The AACR-AstraZeneca Career Development Award for Physician Scientists, in Honor of José Baselga, is a three-year, $300,000 grant to support projects related to the development of innovative targeted therapeutics. Apply by December 5: https://t.co/aJSbwtbMXI
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Timely detection of pre-cancer lesions can improve patient survival but is challenging due to the worsening global shortage of pathologists. Check out our latest work on how deep learning can improve screening capacity by partially automating detection of pre-cancer lesions👇👇
1) Our latest collaboration with @Cyted_UK:Enabling large-scale screening of Barrett’s esophagus using weakly supervised deep learning in histopathology https://t.co/JqR3zxZxGi can reduce pathologists' workload by 48% without sacrificing diagnostic performance #Microsoft & #Cyted
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Interested in deep learning for medical imaging inverse problems at scale? Join the Biomedical Imaging group at @MSFTResearch to work on this beautiful project! https://t.co/GqdGNdy8vw
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On women in science, with @Magda_Skipper, EIC @Nature, from the new Ground Truths podcast. It's algorithmically X-suppressed if I put in the link, which can be found in my profile
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Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy. @broadinstitute @sangerinstitute @getz_lab Thread below 🧵 https://t.co/LGUtJmZ7O2
nature.com
Nature Cancer - Coorens et. al. perform whole-genome sequencing and phylogenetic analyses in a child patient with leukemia that underwent lineage switch following therapy, finding that the AML...
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💫🌟Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer🌟💫 🟠 FGFR inhibitors show positive clinical data in FGFR-driven bladder cancer, but there is room for improvement in urothelial malignancies. 🟠Understanding resistance mechanisms to FGFR inhibitors is
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