Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺
@agingdoc1
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Longevity medicine best practices | healthspan | precision medicine | bio/acc | consulting @ https://t.co/XWGLGiSPyZ Connect: https://t.co/wneqWlNlzd
Joined May 2020
I'm honored to join Harvard Medical School as a part-time Lecturer. If you're a colleague at @harvardmed working on upcoming conferences or educational initiatives in areas such as geroscience, longevity science, precision medicine, aging biotech, translational research,
Opportunity to collaborate:. I've joined Harvard Medical School as a part-time Lecturer, while continuing to serve as Faculty and Trustee at the Geneva College of Longevity Science. If you're affiliated with HMS and open to potential departmental collaborations—whether related to.
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Single dose creatine improves cognitive performance and induces changes in cerebral high energy phosphates during sleep deprivation. "a high single dose of creatine can partially reverse metabolic alterations and fatigue-related cognitive deterioration.".
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Brief structured respiration practices enhance mood and reduce physiological arousal. Melis Yilmaz Balban, David Spiegel, @hubermanlab & coauthors. 🔗 In @CellRepMed, and a huge h/t🎩to Andrew for sharing this technique with the world -🧑⚕️]
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Mitochondrion: A bridge linking aging and degenerative diseases. 🔑Accumulating evidence indicates that restoring mitochondrial function and biogenesis exerts beneficial effects in extending lifespan and promoting healthy aging.
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Taurine deficiency as a driver of aging. "Taurine abundance decreases during aging. A reversal of this decline through taurine supplementation increases health span and life span in mice and worms and health span in monkeys. ". @ScienceMagazine
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Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice .
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High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling.
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"I think the most important part of science is being prepared to be wrong.". —Judith Campisi (1948–2024).
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Assessing the Release of Microplastics and Nanoplastics from Plastic Containers and Reusable Food Pouches: Implications for Human Health. @ACSPublications
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Altos Labs discussed, clip: A single injection of a Yamanaka factor based treatment reported to extend median remaining lifespan of 124-week-old wild-type mice by 25%. Clip from @aspenideas & courtesy @ydeigin .
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Chemically induced reprogramming to reverse cellular aging. Authors: ". rejuvenation by age reversal can be achieved, not only by genetic, but also chemical means. ". @JaeHyun_Yang, @davidasinclair & coauthors. @AgingJrnl
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These eight habits could lengthen your life by decades. 1️⃣Physically active.2️⃣Free from opioid addiction.3️⃣Not smoking.4️⃣Managing stress.5️⃣A good diet.6️⃣Not binge drinking.7️⃣Good sleep hygiene.8️⃣Positive social relationships. 🔑 “According to the results, men who have all eight
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Chronic Inflammation and the Hallmarks of Aging. @JordanBaechle, @Winer_Imm_Lab, and coauthors. @CellCellPress
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With deep sadness, I share the passing of my colleague and friend, Misha Blagosklonny. A brilliant mind behind hyperfunction theory of aging, he was instrumental in advocating for rapamycin as a gerotherapeutic. His impact on the field was immense, and he will be deeply missed🙏
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Mitochondrial dysfunction: A fatal blow in depression.
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Stress and Psychiatric Disorders: The Role of Mitochondria.
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The Relationship Between Plant-Based Diet and Risk of Digestive System Cancers: A Meta-Analysis Based on 3,059,009 Subjects. 🔘Authors conclude "Plant-based diets were protective against cancers of the digestive system.".
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Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content. 🔑"NAD precursor supplementation strategies are less effective than exercise training in staving off muscle and systemic aging.".
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Beyond ATP, new roles of mitochondria.
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Therapeutic Antiaging Strategies.
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Taurine is a potential therapy for rheumatoid arthritis via targeting FOXO3 through cellular senescence and autophagy.
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The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications. "This review delves into the anti-aging properties of metformin, highlighting its role in mitochondrial energy modulation, activation of the AMPK-mTOR signaling pathway, stimulation of
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Spermidine rejuvenates T lymphocytes and restores anticancer immunosurveillance in aged mice.
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How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span.
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Fructose contributes to the Warburg effect for cancer growth (2020).
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I’m saddened to share that Dr. Alan Green, renowned for his pioneering work in the off-label use of rapamycin with the hope of improving healthspan and longevity, passed away yesterday. As more information becomes available, I will update this post. He will be deeply missed. ❤️
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Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial. "Vitamin D supplementation for 12 months appears to improve cognitive
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I am going public today. Here’s why: Kind regards💕,. Agingdoc - David Barzilai MD PhD 🧑⚕️.
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Reminder: I make no claims on authority (not a guru), but focus on topics of interest including pubs good & bad in health & longevity. I do occ give my 2c but no advice: Pub’s mostly for researchers & labs to be aware. Aspire to be helpful & promote good geroscience & advocacy🙏.
FAQs🔬.1) Posts of pubs are not endorsements.2) Selected based on geroscience theme, not as a vet on quality per se.3) I provide no medical or financial advice.4) I accept no compensation; this account is not for monetizing nor publicizing.5) My 1° audience= research community.🙏.
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GLP-1 Based Combination Therapy for Obesity and Diabetes.
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High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation.
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Exercise attenuates the major hallmarks of aging . @Nugarata , Alejandro Lucia2 & colleagues.
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What if there’s no such thing as “aging”?.
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Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna. Great to see this now officially in print @ScienceMagazine @AnastasiaShind @gladyshev_lab & colleagues including @jpoganik @JPCastro_Aging @akaya_lab
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Consumption of coffee and tea with all-cause and cause-specific mortality: a prospective cohort study.
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Urolithin A prevents age-related hearing loss in C57BL/6J mice likely by inducing mitophagy.
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Intermittent fasting and protein pacing are superior to caloric restriction for weight and visceral fat loss.
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Light stimulation of mitochondria reduces blood glucose levels.
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Nicotinamide Mononucleotide Is Safely Metabolized and Significantly Reduces Blood Triglyceride Levels in Healthy Individuals.
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Role of sleep deprivation in immune-related disease risk and outcomes.
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Effects of Resveratrol on Wound Healing.
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Nicotinamide mononucleotide supplementation rescues mitochondrial and energy metabolism functions and ameliorates inflammatory states in the ovaries of aging mice.
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I’m asking for your help to save the Dog Aging Project. This quote and the ones that follow come directly from @mkaeberlein but they speak for me too. ⚕️. 🙏Read, Support, and Re-Tweet. -Agingdoc 👨🏻⚕️👇. “Despite being one of the most productive and impactful NIH supported
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Vitamin D in Depression: A Potential Bioactive Agent to Reduce Suicide and Suicide Attempt Risk. @Nutrients_MDPI
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Midnight snacks might shorten your life - lifespan and healthspan advantages of eating less and at the right time. @MonikaGladka, @DavidLeCouteur & Stephen Simpson (@eatlikeanimals).
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Daily fasting improves health and survival in male mice independent of diet composition and calories (2019).
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Impact of Coffee Intake on Human Aging: Epidemiology and Cellular Mechanisms.
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Physical activity prevents tumor metastasis through modulation of immune function.
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Alzheimer's disease drug development pipeline: 2023.
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The beneficial effects of exercise are in part mediated through the prevention and elimination of senescent cells.
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Vegetarian or vegan diets and blood lipids: a meta-analysis of randomized trials.
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Molecular mechanisms of exercise contributing to tissue regeneration.
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Epigenetic alterations—The silent indicator for early aging and age-associated health-risks.
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Exercise as an Aging Mimetic: A New Perspective on the Mechanisms Behind Exercise as Preventive Medicine Against Age-Related Chronic Disease.
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Olive oil consumption and all-cause, cardiovascular and cancer mortality in an adult mediterranean population in Spain. 👉>2 tablespoons of olive oil per day "may reduce the all-cause, cardiovascular and cancer mortality by more than 30%, 40% and 50%.".
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Association of Daily Step Count and Step Intensity With Mortality Among US Adults. 🔘> daily steps was associated with⬇️all-cause mortality.🔘Compared with >4K steps, >8K steps had only ~half the mortality (>12K: HR=0.35❗️). @JAMANetwork @JAMANetworkOpen
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60 Years of Healthy Aging: On Definitions, Biomarkers, Scores and Challenges.
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"Heads Up" for Creatine Supplementation and its Potential Applications for Brain Health and Function. @darrencandow @DrCreatine @KostasProko @MattStockPhD @kyliekharmon.
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Major depressive disorder: hypothesis, mechanism, prevention and treatment.
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Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway.
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Zero-calorie sweetener linked to heart attack and stroke, study finds. ““If your blood level of erythritol was in the top 25%… there was about a two-fold higher risk for heart attack and stroke. It’s on par with the strongest of cardiac risk factors.” 🤯.
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The Changes of Mitochondria during Aging and Regeneration.
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Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunction.
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Sight restored by turning back the epigenetic clock (2020). @hubermanlab . 👨🏻⚕️If it is behind a paywall for you, here’s the good news: The podcasts have no paywall! 😉 👇.
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Lipid metabolism around the body clocks.
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Scientific meeting report: International Biochemistry of Exercise 2022.
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Gut microbiota and healthy longevity.
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Obesity May Accelerate the Aging Process (2019).
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Update on apolipoprotein B. 🔘"There is now a robust body of evidence demonstrating the superiority of apoB over LDL-C and non-HDL-C as a clinical marker of cardiovascular risk. 🔘LDL-C is not the appropriate marker to assess the benefits of [of Rx]".
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Immune Senescence, Immunosenescence and Aging.
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Real-world evidence for the effectiveness of vitamin D supplementation in reduction of total and cause-specific mortality. 👉 Regular vitamin D supplement users had 11%, 11% & 29% lower cancer, cardiovascular disease and respiratory disease mortality. 💊.
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A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk. @NatureMedicine
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Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired.
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Skeletal muscle as potential central link between sarcopenia and immune senescence (2019). @TheLancet
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Hyperbaric oxygen treatment increases intestinal stem cell proliferation through the mTORC1/S6K1 signaling pathway in Mus musculus. [So does Rapa, but combined HBOT & Rapa has no such effect, possibly due to their opposite actions on the mTORC1/S6K1 axis].
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Effects of physical activity and exercise interventions on Alzheimer’s disease: an umbrella review of existing meta-analyses.
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SIRT6 activator fucoidan extends healthspan and lifespan in aged wild-type mice. “Administering fucoidan to aged mice led to a significant increase in median lifespan in male mice. Both male and female mice demonstrated a marked reduction in frailty and epigenetic age.”. Authors
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Two key geroscience publications today:. 🔎Hallmarks of aging: An expanding universe. 🔎Meta-hallmarks of aging and cancer. Both by Carlos López-Otín, Guido Kroemer & coauthors. @CellCellPress @Cell_Metabolism
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Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease.
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The Key Role of Mitochondrial Function in Health and Disease. @doctorinigo . @antioxidants_OA
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T-Cell Senescence in Human Metabolic Diseases.
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Aging clocks, entropy, and the limits of age-reversal. @fedichev @hacking_aging . "The entropic character of aging drift sets severe constraints on the possibilities of age reversal. However. " (1/2)
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🔖BOOKMARK AND READ. Everyone Should Read @PeterAttiaMD's Outlive📕. It has become my go-to recommendation for anyone new to health & longevity. I briefly discuss here my three favorite chapters to unpack why I find Peter's contribution not only worth your attention, but also
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Plastic Teabags Release Billions of Microparticles and Nanoparticles into Tea. Steeping a single plastic teabag at brewing temperature (95 °C) releases approximately 11.6 billion microplastics and 3.1 billion nanoplastics into a single cup of the beverage
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The impact of COVID-19 on accelerating of immunosenescence and brain aging.
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Metformin decelerates aging clock in male monkeys. 🔎"The results highlighted a significant slowing of aging indicators, notably a roughly 6-year regression in brain aging.".
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The flavonoid fisetin reduces multiple physiological risk factors for dementia.
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Resveratrol activates the SIRT1/PGC-1 pathway in mice to improve synaptic-related cognitive impairment after TBI.
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NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7.
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The senescence-associated secretory phenotype and its physiological and pathological implications.
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The Combined Influences of Exercise, Diet and Sleep on Neuroplasticity🧠
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The role of exerkines on brain mitochondria: a mini-review.
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