ELambe
@LambeLab
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Lambe Lab at University of Toronto, Optophysiology Neurodetectives
Stanford, Yale, now UTORONTO
Joined June 2019
CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer’s disease. @Transl_Psych.#rosmap investigation by Jonas Rybnicek aka @Knedlajz2 of @LambeLab with amazing collaborators @neuronJoy and @DanielFelsky (1/5)
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This afternoon at @physiologyuoft @uoftmedicine.
THIS FRIDAY! Learn from the past with @TerenceKeel, explore the present with @KcD_PhD & @TheRealDrDukes, and help chart a diverse, inclusive future with keynote, @phdgprotein86. We can't wait to introduce our guests to the @uoftmedicine community! RSVP:
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Exciting to have had the opportunity to investigate key questions about human CHRNA5 #nicotinic receptors, especially in aging and #Alzheimers .@Transl_Psych paper link: 🐁Now back to mice to figure out the mechanism! @physiologyuoft @uoftmedicine.
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@Luna3150 @physiologyuoft used optophysiology to show that #CCK interneurons inhibit ventral hippocampus neurons tagged with #retrobead labelling from the nucleus accumbens. Great working with @jckimlab again!
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RT @JDCalebBrowne: Had such a great time working on this with @jblaze8911, from post-talk idea to publication. So happy to see it out in @n….
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Thank you to our wonderful co-authors, collaborators, and @CIHR_IRSC. We gratefully acknowledge the #rosmap individuals and their families. (5/5).
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As amyloid goes up in the prefrontal cortex, the resilience of the chandelier cell population depends on CHRNA5 SNP status. (4/5).
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Jonas took a deep dive into CHRNA5 nicotinic receptors in aging and Alzheimer's. Common human SNPs let us test the impact of CHRNA5 expression versus CHRNA5 function/trafficking. (2/5).
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Great study on the lasting impacts of early life stress.
Our paper now out in @BiologicalPsyc1 Early life stress induced disruption in serotonin networks and sex-dependent improvement on anxiety with mOFC serotonin fiber stimulation. Led by @RamkumarRaksha @moriah_edge
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RT @laurmedlock: Our latest #preprint on touch encoding in rodent mechanoreceptors is out now! 👈. 🔗 Many thanks to….
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RT @kwanalexc: New work from my lab led by Hongli Wang and @heatherkortega. We studied ACh and NE signaling in the mouse medial frontal cor….
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RT @TorontoDementia: 1/Today is #BellLetsTalk Day! Dr. @rajjitarek Executive Director of TDRA, et al, received a @Bell_LetsTalk/@BrainCanad….
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RT @TorontoDementia: 2/Ex vivo work is progressing @LambeLab with a new calcium-imaging approach pioneered by @Sridevi292. Spacing episodes….
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Thought-provoking afternoon @CureGRIN Roundtable. Patient/family perspective and cool research together!. Great to discuss impact of NMDA receptor loss and rescue: Work @npp_journal by @sridevi292 @binko_mary @camielnik in @ajr937 & @LambeLab laboratories.
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#Psychedelics, #serotonin, and beyond:.Neuroscience pioneer and wonderful mentor. Thanks @NatureNeuro .Miss you, George!
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