Lahiri Lab
@LahiriAmit
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Principal Scientist at CSIR-Central Drug Research Institute exploring organellar biology and mucosal immunity connections. Associate professor at ACSIR, INDIA.
CSIR-CDRI, Lucknow
Joined August 2011
🚨 #JustPublished New study from Dr. Amit Lahiri’s group @CSIR_CDRI shows how MCU drives cell migration in rheumatoid arthritis by pushing mitochondria to cell edges. Blocking MCU slows damage—offering a new therapeutic angle! @CSIR_IND 👏 Read it here: https://t.co/MtGGPBLUXg
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We are looking for one Project Research Scientist-II and one RA-1 position. Please send your CV with cover letter . Only very serious inquiries match the requirements. Visit at https://t.co/kTBBv6cczg or CCMB website for more details. Please repost if possible.
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We identify a new mechanism of synovial fibroblast invasion in the rheumatoid arthritis patients. Mitochondrial calcium uniporter might be a crucial target in RA! Thankful to all the collaborators. Please have a look! https://t.co/nR3kkoWAHz
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Check out this awesome work! Congratulations @Dpla_
Excited to share our latest paper in @ScienceAdvances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 https://t.co/YPb6TMTitu
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Check this out!
Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution ( https://t.co/Q9OcuMZBvH), and @sturm_gav et al. dissect the biophysics behind it ( https://t.co/qIVsxYiXDh). Details below! 🔬🧵
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Exciting report from @LahiriAmit group at @CSIR_CDRI ! #Salmonella infection triggers SCV-peroxisome interactions. First-ever identification of a bacterial protein with PTS1, mediating lysosomal cholesterol transport to SCVs. 🦠🧬 Read more: https://t.co/N5xo1w7wmj
#Microbiology
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Extremely delighted to share our recent publication showing how peroxisomes help in inter-organellar cholesterol transport! Now in EMBO Reports! @CSIR_CDRI @AcSIR_India @India_Alliance Great partnership @ammanathan @DipaLab_IISc
https://t.co/QeSMOEeqXg?
embopress.org
imageimageSalmonella effector SseI recruits peroxisomes to serve as bridge for the transport of lysosomal cholesterol to the SCV. SseI is targeted to peroxisomes via a PTS1-like motif. SseI activates...
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J&J folds cardiovascular and metabolic drug unit
endpoints.news
Johnson & Johnson is winding down its pharma division's cardiovascular and metabolic unit, Endpoints News has learned. The decision primarily impacts the sales, marketing and medical affairs teams,...
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Saziya' paper in JCI-INSIGHT.
CLUH functions as a negative regulator of inflammation in human macrophages and determines ulcerative colitis pathogenesis: https://t.co/xsweMvXnSL
@LahiriAmit @CSIR_CDRI
#Gastroenterology
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Glad to share this little piece referring to last paper published in @Nature by Prashar et al. Selective degradation of mitochondrial inner membrane through direct transfer to lysosomes @NatureNV @AndreasReicher8 @ReichertLab
https://t.co/w6uvTbj0HK
nature.com
Nature - Pathway selectively removes inner membrane from mitochondrial organelles.
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Excited to share our paper just out in Nature today! Proud of my amazing Postdoc Dr. Akriti Prashar for this outstanding work! Self-repairing mitochondria use novel recycling system, study finds
sickkids.ca
Summary: The mechanism allows mitochondria to recycle localized damage and maintain healthy function.
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What an insightful lecture! Many thanks to Prof. Samrat Mukhopadhyay @SamratLabMohali for visiting @CSIR_CDRI and delivering a wonderful talk on biological condensates. #Congratulations to the organizers! @CSIR_IND
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Jyotsna Sharma's JBC paper on ORMDL3 was highlighted in ASBMB today. https://t.co/IfmEJ5YfMH
asbmb.org
Lung cancer cells resist ferroptosis. ORMDL3 in ulcerative colitis. Novel genetic variants in thyroid cancer. Read about these recent papers.
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Extremely happy to share our recently published review article published in @TrendsMicrobiol. A very interesting review on SNAREs and pathogenesis of intra-vacuolar bacteria @iiscbangalore
Happy to share our latest review article on the role of SNAREs in intra-vacuolar bacterial infection; it is one of the featured articles in the current issue of @TrendsMicrobiol
@DipaLab_IISc, @iiscbangalore
https://t.co/VJJQ7Nofti
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