Ram Vishwakarma
@R_A_Vishwakarma
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Organic Chemist (Drug Discovery & Glycobiology) at CSIR, Earlier at CSIR-IIIM Jammu as Director, Piramal Healthcare Mumbai, NII New Delhi & Cambridge University
New Delhi
Joined May 2009
Today in @Nature we report a new prime editing strategy that can rescue a common cause of many genetic diseases in a disease-agnostic manner. This approach converts a redundant endogenous tRNA into an optimized suppressor tRNA, enabling a single prime edit to rescue premature
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FDA approves 100th small-molecule kinase inhibitor https://t.co/VjvGosLZ8f From the landmark approval of the anticancer drug imatinib almost a quarter century ago, our latest news feature analyses trends in the field of kinase inhibitors, now one of the major drug classes
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A biochemical code linking chemical RNA modification to extracellular transport - a framework to study the function of extracellular RNAs in the nervous system and beyond | bioRxiv
biorxiv.org
RNAs move through the extracellular space to transmit information between cells, including mammalian neurons, yet how specific RNAs are channeled into these extracellular routes is unknown. Using...
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FDA approves PDE4 inhibitor for idiopathic pulmonary fibrosis https://t.co/fQ45ZBFmA4 Boehringer Ingelheim's nerandomilast is the first new drug to be approved for this fatal lung disease in more than a decade
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A new platform for targeted delivery of drugs (biologics and nucleic acid therapies) through blood-brain barrier for neurological diseases
ššØš¦š©šš§š² ššš°š¬: @Roche will pay @ManifoldBio $55M up front, and up to $2B in milestones, to collaborate on multiple next-generation brain shuttles for neurological diseases. Full video: https://t.co/zGchJCPMjr
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We keep getting better at controlling the immune system, with big implications for treating diseases 1. cGAS delivery via mRNA/nanoparticle revs up cancer immunotherapy https://t.co/AnNHe83M0r 2. Off-the-shelf CAR-T as good as patient-specific for lymphoma
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Inflammation and Atherosclerosis: IL-1b, IL6 inhibitors. ColchicineĀ has emerged as the first anti-inflammatory drug approved for ASCVD prevention, with consistent benefits in LoDoCo, COLCOT, and LoDo trials
š„Ā Inflammation: The Next Frontier in Atherosclerosis Therapy A new comprehensive review byĀ Peter LibbyĀ andĀ Oliver SoehnleinĀ (Immunity, 2025) revisits one of the most powerful ideas in cardiovascular medicine:Ā atherosclerosis is an inflammatory diseaseĀ ā and inflammation is now
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Enduring value of immunization against respiratory viruses (Covid-19, RSV, Influenza) as a cornerstone of preventive care, supporting rigorous, evidence-based vaccine deployment. Spreading Anti-vaccine misinformation is dangerous for public health | NEJM
nejm.org
Changes in the vaccine advisory process in the United States have disrupted immunization guidance, which reinforces the need for independent evidence review to inform decisions regarding immunizati...
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Now online! Remembering David Baltimore (1938ā2025)
cell.com
David Baltimore, one of modern biologyās most influential scientists, passed away at his home in Woods Hole, Massachusetts, on September 6, 2025 at the age of 87, leaving legions of former trainees...
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This is why we must restore all cancer funding.
A single dose of a new cancer drug made a brain tumor almost disappear ā in just five days. Doctors at Massachusetts General Hospital reported ādramatic and rapidā tumor regression in the first patients treated with a next-generation form of CAR T-cell therapy for glioblastoma,
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Nature research paper: Designing allosteric modulators to change GPCR G protein subtype selectivity https://t.co/ohDLmzAFjh
nature.com
Nature - Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching...
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Avidity Biosciences is developing drugs that use an emerging technology known as antibody oligonucleotide conjugates to deliver RNA treatment to muscles. - WSJ
wsj.com
The Swiss pharmaceutical company says the purchase would complement its existing pipeline of treatments for neuromuscle disorders.
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MIT found that the amino acid cysteine boosts stem cell repair by 30% via immune signals, healing radiation, or chemo damage. This research is the first to pinpoint a single nutrient that directly boosts the gut's regenerative capacity. Note that this was mechanistic rodent
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Diversity of Interferon-independent antiviral defenses that mammalian hosts utilize to block viral infection | Journal of Virology
journals.asm.org
Interferons (IFNs) are classified into three groups based on the different receptors they bind and have been reviewed in detail elsewhere (1ā4). Here, we will focus on discussing the type I IFN...
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Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane
elifesciences.org
Genetic studies reveal that polyunsaturated lipids do more than simply increase the fluidity of the cell membrane.
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A powerful strategy for programmable import of chemically diverse building blocks to expand genetic code | Nature
nature.com
Nature - Bacterial ATP-binding cassette (ABC) transporters can be utilized and engineered to transport non-canonical amino acids into Escherichia coli for highly efficient synthesis of proteins...
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Interesting new perspective and synthesis of ideas which were long suspected and perhaps obvious - The Hunt for the Worldās Oldest Story | The New Yorker
newyorker.com
From thunder gods to serpent slayers, scholars are reconstructing myths that vanished millennia ago. How much further can we goāand what might we find?
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Very excited that the clinical trial results for our PRIMA retinal prosthesis are published today in the New England Journal of Medicine! This is the first time that patients who are blind due to photoreceptor loss have been able to intuitively see again.
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The New England Journal of Medicine Reports Science Corp.ās PRIMA BCI Implant Restores Functional Central Vision to Patients with Geographic Atrophy Caused By Age-Related Macular Degeneration
science.xyz
Science Corporation is a clinical-stage medical technology company.
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ElecsysĀ® pTau181 by Roche The first FDA-cleared blood test for use in primary care to rule out Alzheimerās-related amyloid pathology https://t.co/diyk9tSRDn
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