
Samrat Mukhopadhyay
@SamratLabMohali
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Professor @IISERMohali Editor @BiophysJ Studying biological condensates associated with cell physiology and disease Attended @IIScBangalore @ScrippsResearch
IISER Mohali, Punjab, India
Joined July 2015
Happy to share our latest paper published in Science Advances @ScienceAdvances @AAAS. Congratulations to my incredible students, Sandeep @Sandeep61011718, Roopali @RoopsieK (joint-first author), Anusha @AnushaSarbahi & Ashish @AshishJ87810510 @IISERMohali.
science.org
A chaperone tasked with protein quality control tunes the phase behavior of tau and prevents its pathological phase transitions.
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Vitamin B12 structure determination by Dorothy Hodgkin was a tour de force. It's mind-boggling to imagine that such a complex exquisite molecular structure was solved at the atomic resolution 70 years ago in 1955. It was such a quantum leap in structural chemistry and biology.
#OnThisDay 20 August 1955, Dorothy Crowfoot Hodgkin and her colleagues published the final structure of vitamin B12 which has the most complex structure of all vitamins.
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RT @ShorterLab: The small GTPase Ran defines nuclear pore complex asymmetry: Cell
cell.com
Nuclear pore complexes at the nuclear envelope are asymmetric structures, whereas those in cytoplasmic or nuclear membranes are symmetric. The (a)symmetry of nuclear pore complexes and peripheral...
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RT @ShorterLab: Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies | JACS Au….
pubs.acs.org
Inhibition of amyloidogenic-protein oligomerization and aggregation is a promising therapy-development strategy for proteinopathies, such as Alzheimer’s and Parkinson’s diseases, in which proteins...
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RT @PBensalah: Successful synthesis of neutral N₆ opens door for future energy storage.
phys.org
Nitrogen finally joins the elite tier of elements like carbon that can form neutral allotropes—different structural forms of a single chemical element. Researchers from Justus Liebig University,...
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RT @AsimovPress: Protein designers have long dreamed of building new enzymes from scratch. Unfortunately, enzymes are highly dynamic; they….
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RT @NaturePortfolio: A feature in @Nature explores how physicists are developing laboratory tests to give insight into the true nature of g….
nature.com
Nature - Physicists are developing laboratory tests to give insight into the true nature of gravity.
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RT @cenmag: For the first time, researchers have created an all-carbon molecular ring that is stable in solution at room temperature, with….
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RT @OxfordChemistry: ⭕ Synthesising a new carbon allotrope. Amazing work from @HLAGroupOx, published this week in @ScienceMagazine: a cyclo….
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RT @UCLAchancellor: The internet as we know it began with federal research funding and a breakthrough at @UCLA. In 1969, a UCLA team sent t….
newsroom.ucla.edu
From the internet to the ozone layer, AI to the human genome, UC scientists have turned funding into history-making, economy-boosting solutions.
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What a brilliant paper: "An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli" in @ScienceMagazine from the labs of Christian Diercks and Peter Schultz @ScrippsResearch. Paper:.Scripps News:.
science.org
Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functio...
Scientists in the lab of Peter Schultz, the President and CEO of Scripps Research, and assistant professor Christian Diercks (@DiercksLab) have developed a synthetic biology platform that accelerates evolution itself—enabling researchers to evolve proteins with useful, new
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RT @ShorterLab: A multichaperone condensate enhances protein folding in the endoplasmic reticulum:
nature.com
Nature Cell Biology - Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing...
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In my laboratory at Cornell University we work on, among other things, prebiological organic chemistry, making some notes of the music of life. -Carl Sagan, Cosmos (1980). It'd have been fascinating to work with him to address the central question of our existence on this planet.
Now rereading "Cosmos" by Carl Sagan after 25 years. This 1980 book is a page-turner and a must-read book for anyone who is interested in the story of cosmic evolution, science, and civilization.
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RT @GaitiHasan: This story is about Prof. P Babu isolating a key mutant in C. Elegans that subsequently led to the discovery of microRNA.
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RT @Nature: Nature research paper: Lithium deficiency and the onset of Alzheimer’s disease.
nature.com
Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...
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It's so wonderful to see that the Indian Institute of Technology (IIT) Jodhpur featured the exciting research being carried out in the laboratory of Neha Jain @Jain_Lab, my former PhD student @IISERMohali. We are very proud of Neha! .
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