Santosh Chauhan
@Chauhanlab_ILS
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Senior Principal Scientist, CCMB, Hyd. Fellow- FNA, FNASc, FASc, DBT-Wellcome fellow (past), EMBO Global Investigator fellow. Views are personal
Hyderabad, India
Joined March 2017
Today marks as 8 years as an independent faculty. Published some intense fundamental studies (with 5 cover pages) from India. It was not cakewalk but made it. Very Thank ful to my Students , Mentors, Collaborators and importantly Family. looking forward.
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Thanks Prasad. This is a beautiful futuristic Summary.
Programmed cell revival offers immense promise—from faster recovery after a stroke or heart attack to regenerating tissues in degenerative diseases. One day docs may coax the body to heal itself by awakening the new-found hidden programme @Chauhanlab_ILS .
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and collaborators @yelagandula_ram @RohanKhadilkarr @anindyagroy @TejSowpati @DrPunitPrasad1 @keshu_VRimmCh @BRIC_CDFD @DBT_NBRC @CRI_ACTREC SORRY IF MISSED SOME ONE n/n.
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Death to regeneration !!!!!. There are many questions, which we cannot answer about this process at this moment. We are thankful to many for this journey. first of all, funding from @DBTIndia @ICMRDELHI @ANRFIndia @CSIR_IND @ccmb_csir @ILS_Bhubaneswar and15/n.
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THIS STUDY SHOWS THE POWER OF BASIC SCIENCE. JUMPING TO TRANSLATION may give rise to one product, which may fail because you dont know basic. However, Basic opens a new field. Both should go hand-in-hand. But who will tell to bandmasters :) 14/n.
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This work is highlighted in the journal @embojournal in the news and views section. Thanks to Dr. Thirumala D Kanneganti @ThiruKanneganti for such an elegant summary of work!! 13/n
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Stem cell proliferation in Drosophila👇.This study not only challenges many dogmas but also opens a door to regenerative medicine.This work is now filed for Indian and International patents.We started with observation and ended up filing patents and This is just a beginning 12/n
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Mouse corneal injury model, Axon regrowth in C. elegans, Tadpole tail regeneration and 11/n
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This isn’t just a petri dish phenomenon. Similarity between the “onset of revival” and “tissue healing repair /regeneration pathways” prompted us to test it in different models of tissue healing and regeneration. 11/n
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the complete renewal of cells. Multiple other pathways pitch in, but NF-κB acts as the bandmaster of this revival orchestra. Inhibiting it blocked cell revival and tissue regeneration. Video below 10/n
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The pathways linked to development, regeneration, and stemness were activated at the onset of PCR. Subsequently, vital pathways governing metabolism, organelle biogenesis, membrane trafficking, transport, and cytoskeleton remodeling are activated, resulting in 9/n
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RNA-Seq and ATAC-seq at time points throughout the process told us - this isn't a random event; it’s tightly regulated. Chromatin becomes more accessible, enabling a transcriptional wave of genes in a very step-wise manner -that is why we called it PROGRAMMED CELL REVIVAL. 8/n
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These unusually large lysosomes were surrounded by a dense network of mitochondria, forming a novel structure very likely associated with intense metabolic networking reactivation. THE TWO AVENGERS TOGETHER to save the Cell world. 7/n
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almost nothing. During the early revival, lysosomes became significantly enlarged, highly acidic, and looked like MVBs. Cells need lots to remove garbage? Also, synthesize a lot, so high catabolic activities? Lysotracker green and magic red 👇6/n
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repeat-repeat-repeat, different ways. This was Fascinating! We got curious and imaged all the organelles throughout the Cell death and revival phase (a total of 16 hours). To our surprise, all organelles regenerated within 5-6 hours of a completely fragmentated state or from 5/n
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floating cells are getting stuck back to the surface and reviving (Thanks, Kautilya!). I laughed at him and said, Hope you're not drunk. But when he left the room, I thought, what if he is correct? I asked him to repeat the experiment, and others in the lab . 4/n
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aspects of Lysosomal Cell Death. My former PhD student, @kjena21 , was supposed to add LLOMe (lysosomotropic agent)to the cells and collect them when they are floating in media and considered dead. LUCKILY, he forgot.He enters my room after three hours and says that the dead, 3/n
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We here discovered a genetically encoded intrinsic revival code, which we named Programmed Cell Revival (PCR), that allows cells to recover from near-death states.The story begins about 5-6 years ago, when we wanted to understand some 2/n
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FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n
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Ha ha ! Absolutely 💯 . mostly copy pasted from PI website.
PhD Scholars, if u r applying for a PDF position, plz chk what that lab is working on. Sending an email that the PI’s groundbreaking work on XYZ has inspired u, & ur expertise is aligned with PI’s ABC work, while the PI has not done either XYZ or ABC, won’t help your application.
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