Luis de la Torre-Ubieta
@LTULab
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We study human cortical development and neuropsychiatric disease. BSCRC member: https://t.co/TLqwZF5CYW
Joined January 2018
Thanks for helping us share this work more broadly. Very excited to see how this resource will facilitate better understanding of brain development and neuropsychiatric disorders.
Researchers @UCLA & @Penn led by @LTULab & @mikejg84 have uncovered over 200,000 new gene transcripts in the developing human brain. Their findings could enhance our understanding of brain maturation & genetic risks for neuropsychiatric disorders.
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Thanks to all of our lab members and collaborators @NanaMatoba @jsteinlab @GeschwindLab @mikejg84 for their important contributions to this work.
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New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome. #brain #singlecell #multiomics #DownSyndrome .
biorxiv.org
Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this...
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RT @XWilliamYang1: Here is a press release by @UCLAHealth that nicely summarizes the key findings from our paper published today @CellCe….
uclahealth.org
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RT @hyejung_won: 1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotr….
cell.com
High-throughput experimental validation of genetic variants linked to eight psychiatric disorders reveals the regulatory mechanisms underlying variants with pleiotropic and disorder-specific effects.
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RT @DeRubeisLab: Re-upping this ad for a #postdocposition in our lab 🧠 🧬🔬 . RT appreciated 🙏.
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RT @UCLAstemcell: 📢 Our center is recruiting MULTIPLE new faculty working in stem cell research and regenerative medicine! Apply today to j….
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Come see our work studying mechs of cortical development and neurodevelopmental disorders at #SfN24. Pstr. 257.12 / A12, Oct 8, 11-12p .Pstr. 317.24 / A22, Oct 8, 4-5p. We have openings for scientists with expertise in genomics interested in neuroscience. Come meet me at SFN!.
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RT @g_chen: New from @GeschwindLab: As part of the PsychENCODE Consortium, we performed single nucleus RNA and ATAC sequencing on ASD and C….
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RT @doyouseewhy: How do quantities of brain cells – the fundamental unit of life – differ in Alzheimer’s disease, schizophrenia and autism?….
science.org
Analysis of cell-type composition from 1270 brains across three diagnoses implicates endothelial cell loss in Alzheimer’s disease.
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RT @mikejg84: New in @ScienceMagazine: Our paper mapping gene/isoform/splicing regulation at pop-scale during human #neurodevelopment. Maj….
science.org
Neuropsychiatric genome-wide association studies (GWASs), including those for autism spectrum disorder and schizophrenia, show strong enrichment for regulatory elements in the developing brain....
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Very proud of this incredible team which led this innovative work to move us closer to understanding the impact of isoform diversity in the developing brain and neuropsychiatric disorders.
Its out today in @ScienceMagazine. Special thanks to @connorjops for his prompt analytical support during the project, and @ckvuong for her meticulous review ensuring no oversights in the manuscript.
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RT @ScienceMagazine: This week in Science, @ScienceAdvances, and @ScienceTM, the #PsychENCODE Consortium lay out findings based on examinin….
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RT @ckvuong: Our paper on splicing isoforms in developing human brain is finally out in @ScienceMagazine! So grateful to @LTULab and @mikej….
science.org
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain...
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Wonderful time and science yesterday at @UWWaismanCenter. Thanks for the opportunity to share our work!.
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RT @AzadBonni: Interested in postdoctoral training in fundamental neurobiology in an environment of a world-leading R&D unit, apply to have….
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RT @mad_lancaster: We are delighted to share our latest publication! It’s a useful resource to the organoid community, but also uncovers so….
cell.com
Proper cell fate acquisition in time and space determines tissue architecture, but how tissue architecture influences cell fate is less clear. Lancaster and colleagues investigated this form-fate...
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