Azad Bonni
@AzadBonni
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Senior Vice President @Roche, head of Neuroscience & Rare Diseases in Pharma Research and Early Development (pRED)
Basel, Switzerland
Joined October 2018
In case you missed it: I am proud to share one of our studies from the summer, in which we report a conceptual advance in the science and medicine of ubiquitin signaling in genetic neurodevelopmental disorders! https://t.co/tG1EfLcpF8
nature.com
Nature Medicine - The antisense oligonucleotide rugonersen has acceptable safety and tolerability in children with Angelman syndrome and shows partial normalization of electroencephalogram...
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Delighted to announce @LukaKulic90270 has been appointed VP & Head of Early Development in Neuroscience & Rare Diseases at @Roche pRED! Luka brings expertise and proven track record to advance our early clinical pipeline toward medicines for patients with neurological disorders!
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Congratulations @HaoChen_neuro, @cjfMDPhD, and @AlbertHKimMDPhD as well as collaborators for an exciting study and identification of a novel ubiquitin signaling link in the brain with implications for understanding genetic neurodevelopmental disorders!
Congrats to @HaoChen_neuro and the team on his paper on Hao-Fountain syndrome. A fantastic collaboration with @AzadBonni and Cole Ferguson. @WashUNeurosurg
https://t.co/pEkLzukm9P
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Congratulations @dngman and colleagues on your publication! This area of research is critical to our ability to develop novel biomarkers for the study of brain disorders. Keep up the great work!
To preprocess or not to preprocess your #EEG 🔮when using #ML? 💫An enhanced version of our latest work at @Roche is now published in @eBioMedicine
https://t.co/5Agp61gnWD
#DeepDive #Thread 🧵in next post 👉👉🏾👉🏻
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Excited about the partnership with @AscidianTx, which aligns with @Roche pRED's gene therapy strategy in neuroscience! The collaboration promises to advance treatments for patients with devastating neurological disorders. #Neuroscience #RewritingRNA #RNAExonEditing #genetherapy
It’s an exciting day at Ascidian as we announce a collaboration with @Roche. We’re thrilled to combine our #RNA #ExonEditors with the next generation #CNS delivery capabilities of Roche to tackle complex neurological diseases. Learn more👉 https://t.co/L4uS4UuByq
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Pleased to share our paper in @NatureMedicine presenting an exploratory analysis of a Phase 2 study in Parkinson's disease! It is a significant step forward toward developing a treatment that can effectively slow the progression of Parkinson's disease. https://t.co/Ywfnq0S2ok
nature.com
Nature Medicine - An exploratory analysis of the 1-year clinical trial PASADENA in individuals with early-stage Parkinson’s disease suggests that prasinezumab might reduce motor signs...
✨There is hope that Parkinson's will one day be eliminated. Recognition of the importance of certain protein formations has brought us to the brink of a revolution. The goal: personalise medicine for each patient. 🌈 Check it out: https://t.co/ZHqaQwfhXl
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Interested candidates with strong background in any area of biology should send a cover letter and CV by email to fabienne.dietler@roche.com, c/o Azad Bonni, MD, PhD, Senior Vice President and Global Head of Neuroscience and Rare Diseases, Roche pRED. 5/5
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that orchestrate neuronal connectivity in the brain. For background information, see the following papers (Yang et al. Science 2016; Yamada et al. Nature 2019; Chen et al. Nature 2022; Ferguson et al. Mol Cell 2022). 4/5
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We employ diverse tools from human iPSC-induced cells and mouse genetics to single cell transcriptomics and proteomics to genome architecture and epigenomics to morphology and electrophysiology to define the epigenetic, transcriptional, and ubiquitin signaling networks 3/5
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The chief goal of the Bonni laboratory is to identify the key principles and mechanisms that govern the assembly and function of neural circuits in the brain and to determine how deregulation of these fundamental mechanisms contributes to neurological disorders. 2/5
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Interested in postdoctoral training in fundamental neurobiology in an environment of a world-leading R&D unit, apply to have the best of both worlds! Please RT 1/5
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Here is the leading edge of #RNAtherapeutics!
Transforming healthcare through #RNA innovation🧬 Exciting moments ahead as we gather around transformative objectives, firmly believing in the potential of #RNAtherapeutics! Find out more about our #RNAHub:👉 https://t.co/pRfemMaRhd
#OTS23
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So humbled and grateful to @WUSTLneurosci for this incredible honor!! Super excited and looking forward to share a wonderful day of science with colleagues and friends from around the world at Washington University in St. Louis @WUSTL!!
Please mark your calendars for a very special event in January: the Azad Bonni Symposium, honoring the contributions of @AzadBonni as Chair of the Department of Neuroscience. Find details & register here:
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Congratulations @HongkuiZeng!
Our own @HongkuiZeng has been elected to @theNAMedicine! One of the highest honors in the health and medicine field, the election recognizes Zeng for her outstanding professional achievements and commitment to service.
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We are very excited to collaborate with @ionispharma , continuing our deep commitment to finding treatments for #Alzheimer's and #Huntington's diseases! Thanks to the many colleagues who made this partnership possible!
Today, we announced a new collaboration with Ionis to develop two novel treatments for Alzheimer’s and Huntington’s disease. Teaming up with Ionis is a testimony to the strength of this partnership and the benefits both companies see in working together. https://t.co/uSSm5vUeH8
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This is a fantastic opportunity at the intersection of academia and industry, where you can have the best of both worlds in the vibrant city of Basel!
We’re seeking Early Career Scientists to establish their own independent #research program, with competitive funding, across three key focal areas. Open to mature #scientists with PhD or Postdoctoral training in #HumanModelSystems. Apply to #TeamIHB here: https://t.co/Ylacs3MTQw
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Academic researchers from around the world with experience in human in vitro model systems / #organoids : If interested to join us, please reach out https://t.co/5Ki03fy4NH
@IHB_Research
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We are excited to announce the launch of the Institute of Human Biology. The institute brings together scientists from academia and industry to accelerate breakthroughs in R&D, using human model systems. $RHHBY $ROG #RocheInnovation #Science
https://t.co/wwi7tg2qsl
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Congratulations @ravi_jagasia and team @Roche!
Interesting: Researchers at @Roche present the targeting of neuronal lysosomal dysfunction caused by #Parkinsons-associated β-glucocerebrosidase deficiency with an enzyme-based brain shuttle construct https://t.co/8gGfHG6Av6
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Congratulations @MEGNeuro, @erin_schuman, and Christine Holt!
Congratulations to The Brain Prize winners of 2023: Professors Michael Greenberg, Christine Holt and @erin_schuman. They have done pioneering work on molecular mechanisms of brain development and plasticity Read: https://t.co/2E2Ij4reP3
#TheBrainPrize #BrainPrize23 #neuroscience
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