Jason Stein
@jsteinlab
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Associate to the Prof, UNC Neuroscience Center & Dept of Genetics
Chapel Hill, NC
Joined July 2017
New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome. #brain #singlecell #multiomics #DownSyndrome
https://t.co/Rqzg66QQzd
biorxiv.org
Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this...
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Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors @jsteinlab @NanaMatoba @jmvalone4 @BrandonDLe
https://t.co/M38j3Ymtop
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It’s been a long journey🚢, with about 1 & 1/2 year since posting on bioRxiv and of course even longer since the project started, but our paper has finally been published in @NatureNeuro 🌠 Congrats @BrandonDLe @jmvalone4 @jsteinlab and all co-authors ! https://t.co/oRwbKavXlh
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📢New from @jsteinlab! 📰 #Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis https://t.co/eljvgrFFvG
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Dr. Jason Stein's lab (@jsteinlab) at @UNC determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates. @stemcellreports | https://t.co/hdJTP3RaLh
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The authors of @AJHGNews' latest article identify cell-type-specific genetic regulation of RNA editing and alternative polyadenylation in human neurons and neural progenitor cells. Read the full article here: https://t.co/KcdXoNj6Rt
#ASHG @jsteinlab
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I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with @jsteinlab, @srikosuri, @mikelove, @_josedavila, @brad_ruzicka, @AP_Boyle. 🧵 follows.
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants
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We @jsteinlab are delighted to present our recent preprint investigating the impact of genetic variants on cell-type-specific post-transcriptional regulation in human brain
biorxiv.org
The function of some genetic variants associated with brain-relevant traits has been explained through colocalization with expression quantitative trait loci (eQTL) conducted in bulk post-mortem...
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Neocortical Neurogenesis in Development and Evolution edited by WIELAND B. HUTTNER is out https://t.co/DwsR2DBpX4. Superb resource to learn about cortical progenitors; lineages; specification; migration; patterning; cortical regionalisation; folding; disorders; evolution.
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Excited to share a new preprint on the cross-site reproducibility of human cortical organoids co-led with Elisa Waxman & Deborah French at CHOP and Satoshi Yamashita & Kazue Hashimoto-Torii at Children's National and my PI @jsteinlab! https://t.co/Ze6YKqrcWM 1/9
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Learn how Felix Kyere, Ian Curtin, Jason Stein and colleagues of @UNC perform whole-brain single-cell imaging and analysis of mouse brains using MRI, tissue clearing, and light-sheet microscopy. Watch on JoVE: https://t.co/0dkzIQWXck
@jsteinlab @FelixKyere @curtin_ian
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Our recent work together with @jsteinlab and @mikelove is published in @GenomeBiology, to understand cell-type specific causal gene regulatory networks via mediation analysis. To access the full article please click https://t.co/Cui9iivvjB
genomebiology.biomedcentral.com
Background Genetic variation influences both chromatin accessibility, assessed in chromatin accessibility quantitative trait loci (caQTL) studies, and gene expression, assessed in expression QTL...
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Super excited to host @BrandonDLe from @jsteinlab next Tuesday at 3pm for the #neurogenomics seminars. Bran will present the lab's excellent recent work linking wnt pathway activation with context specific regulatory QTLs. DM/email for the zoom link
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The lightsheet has landed! 🔬🤩🎉 After a lot of preparation and a full week of install, we were thrilled to see some images of distinct nuclei in dense regions of cleared mouse brains and are excited to welcome the @ASIImaging ct-dSPIM to the @UNC_NMC!
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2 major earthquakes hit Turkey and Syria on Monday affecting many cities where ~15 million people live. The death toll is in the order of thousands and still rising. Please donate and share this fundraiser led by researchers:
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Check out our lab's recent work mapping response ca/eQTLs in the context of Wnt stimulation 🪄⚡️.
Excited to share our new preprint, where we investigated context-specific gene regulation and QTLs by stimulating 🪄⚡️ the Wnt pathway in human neural progenitor cells🧠 (co-led with two wonderful grad students @brandonDLe @jmvalone4 in @jsteinlab) https://t.co/CNDbm2tvnR 1/🧵
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GWAS in a dish! GWAS of neural progenitor cell proliferation on lithium treatment (n=80) identified a locus on chr 3, a known risk locus for bipolar disorder, schizophrenia and intelligence. Beautiful! https://t.co/fFB4ceS599
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🧬A GWAS study from @jsteinlab has found a common genetic variation that influences lithium-induced neural progenitor proliferation in cell culture. Nice approach to identifying context-specific effects of psychotropic drugs. 👇 https://t.co/YIOCXB93P5
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Cell culture-based GWAS approach identifies lithium-induced pharmacogenomic effects on human neural progenitor proliferation mediated by GNL3. Associated with risk for #bipolardisorder and #schizophrenia, intelligence: https://t.co/yQzLqoTRO4
@BiologicalPsyc1
@jsteinlab
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@UNC_Biology has a job search for a tenure-track Assistant Professor in neurobiology. https://t.co/SRZP2tlNga UNC is a pretty amazing place to do your research, and Chapel Hill is a fantastic place to live, so consider applying and tell your friends!
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