Ashok Patowary, PhD
@ashokpatowary
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Genomics Researcher @UCLA / Associate Project Scientist (Geschwind Lab)
Los Angeles, CA
Joined September 2009
Its out today in @ScienceMagazine. Special thanks to @connorjops for his prompt analytical support during the project, and @ckvuong for her meticulous review ensuring no oversights in the manuscript.
science.org
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain...
New Preprint #brain #neocortex #singlecell #isoseq #longread. Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of neurodevelopmental disorders
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RT @LTULab: New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the deve….
biorxiv.org
Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this...
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In general single cell long read RNAseq don't capture longer Isoforms; but not anymore; we can do capture longer Isoforms with single cell RNAseq also.
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Hard to capture long isoforms in single-cell RNA-seq. We have finally optimized an existing method to capture the majority of expressed isoforms, including longer ones. @nanopore #LongRead #SinlgeCell #Isoform
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RT @ItaiYanai: How to write a grant?.1. Write it for the reviewer, not you, the applicant. 2. Communicate in stories. 3. Make your story co….
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RT @LabWaggoner: Long-read sequencing for 29 immune cell subsets (Transcriptomic Resource of Immune Cells using Long-read Sequencing, TRAIL….
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#AcademicFrustration .When someone asked you what your contribution was to the project that you led for 4 years, where you created the basic framework, standardized the majority of the processes, kept quality high, and validated every step.
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RT @ScienceMagazine: In a new Science study, researchers lead one of the most comprehensive investigations to date of splicing and resultin….
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RT @vipintukur: A NEW study has unveiled the most detailed view of the complex biological mechanisms underlying autism, showing the first l….
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RT @UCLAstemcell: Researchers @UCLA & @Penn led by @LTULab & @mikejg84 have uncovered over 200,000 new gene transcripts in the developing h….
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RT @ckvuong: Our paper on splicing isoforms in developing human brain is finally out in @ScienceMagazine! So grateful to @LTULab and @mikej….
science.org
RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain...
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RT @ScienceMagazine: This week in Science, @ScienceAdvances, and @ScienceTM, the #PsychENCODE Consortium lay out findings based on examinin….
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Also thanks to all the other coauthor Pan, Xinzhou, @kangchenghou @survolerLA Naihua, MichaelMargolis,.@DanielVo10 Xusheng @CLiu_Upstate @bpasaniuc @jsb_ucla @mikejg84 @LTULab.
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Over a decade in the making. Congratulations to all the co-authors for their hard work. Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function
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RT @ItaiYanai: Knowing how to give a good talk is a crucial skill to have, but it's mostly not formally taught very well. Here's a 🧵on my s….
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RT @m_spatowary: @USAndChennai I m a postdoc researcher @UCLA_Pathology @dgsomucla. Travelled to India for family emergency, submitted doc….
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RT @ScienceMagazine: In 21 papers across Science, @ScienceAdvances, and @ScienceTM, researchers with the #BICCN consortium present an atlas….
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RT @IanDWagreich: The @StateDept visa bulletin for Aug, 2023 was issued today. There is a lot not to like. EB-1 for India has retrogresse….
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RT @EnardHellmannWG: We are happy to share our latest work on #ambientRNA in single-cell and single-nucleus RNA-seq experiments, out now in….
link.springer.com
Background In droplet-based single-cell and single-nucleus RNA-seq experiments, not all reads associated with one cell barcode originate from the encapsulated cell. Such background noise is attribu...
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RT @MartinUCSF: Excited to share our new preprint:. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. https://t.….
biorxiv.org
The sheer complexity of the brain has complicated our ability to understand its cellular mechanisms in health and disease. Genome-wide association studies have uncovered genetic variants associated...
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