Can anyone recommend a good mRNA therapeutics conference that is coming up? Ideally one that is broadly attended by both industry and academics?.

This amazing work was led by @MadernMax and @_SoraY with a great collaboration with @mbauer67 and Olivier Witteveen. @_Hubrecht @oncodeinstitute @TNW_BN.

Join millions who have switched to Grok.

Our paper on Stopless-ORF Circular RNAs (socRNAs) is now out in Cell. By high-res tracking and comparing translation by either single or multiple ribosomes, we find that ribosomes cooperate to overcome pausing to ensure fast and efficient translation.

Fantastic, multidisciplinary team effort by Huib Rabouw, @jschoko98 and @muellermicha_ with enormous help from @BaarsMatthijs and @JakobPuschel, and great collaborations with Ron Fouchier's and @HansClevers' groups!.

Our new paper is out: "Mapping the complete influenza A virus infection cycle through single vRNP imaging". Combining single-molecule imaging approaches with in situ transcriptomics, we identify many non-canonical infection pathways. Movie: viral entry

I too have started at Bluesky, the Twitter/X alternative (@marvintanenbaum.bsky.social), please come and join us, the science community at Bluesky is growing very rapidly!.

RT @_knaw: Vandaag in @volkskrant @ADnl:. Kabinet, maak niet kapot wat ons land zo succesvol maakt. Stop met de onverantwoorde #bezuiniging….

Happy 10th birthday SunTag! Thanks for all the great times we've had together!.

Thanks for all the thoughts. I do agree that having the actual text there is better than referring to the previous paper, which is annoying for the reader. So perhaps copying the text and adding the citation makes most sense.

When writing a manuscript, is it acceptable to copy-paste a paragraph from the methods section from your own previous paper (e.g. describing your transfection/blotting/etc protocol)?.

Super excited to start my summer sabbatical next week in @GreenLabJHMI !! Looking forward to a ribosome filled summer!.

If you write a big grant, do you generally use all the maximally allowed space/character count?.

This is indeed very interesting!.

Are you an ambitious 2nd year BSc student in life science from an underrepresented minority group in NL, sign up for the Hubrecht Talent Program! An amazing opportunity with mentoring, Hubrecht internship, support in MSc applications, conference and much more!. Pleat RT!

Attaching multiple poly(A) tails to an mRNA to increase expression, such a interesting idea!.

RT @MadernMax: Check out our two new papers! We delevoped a method to follow individual translating ribosomes for hours in living cells, an….

One of the lead authors @_SoraY is also on the job market for PI positions, and I highly recommend recruiting her if you can!!.

In the second new paper from the lab, we use socRNAs to compare either single or multiple ribosomes on an mRNA and find that ribosomes help each other out during translation to overcome obstacles. Amazing work jointly led by @MadernMax and @_SoraY .

Some highlights: .- Different ribosomes move at distinct speeds; .- Initiation factor eIF4A promotes translation elongation; .- Ribosome frameshifting occurs broadly on 'normal' mRNA sequences;.- Ribosome targeting drugs differentially effect translation elongation.

Two new lab papers: In the first paper we develop Stopless-ORF circRNAs (socRNAs), a technique to measure translation by individual ribosomes with incredible precision. Amazing work jointly led by @MadernMax and @_SoraY.