Matt Disney
@disney_lab
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Walker of the earth RNA & Chemical Biology practitioner @J_A_C_S associate editor
Jupiter, FL, USA
Joined August 2013
https://t.co/dC3maLE7a0 Cool Paper on studying RNA decay with nanopore sequencing
pubs.acs.org
RNA is the key biomolecule in innumerable diagnostic and therapeutic applications, but its chemical instability plagues researchers and clinicians alike. Gel electrophoresis remains the predominant...
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Congrats to Zijun Jiao (Feng Yin), et al. on their new JACS paper! Liposome-based RiboTACs enable efficient RNA degradation & antitumor activity — a big step for RNA-targeted drug discovery. https://t.co/yhG8GU9zKQ
#RNA #RiboTAC #JACS #DrugDiscovery
pubs.acs.org
RNA molecules play critical roles in various diseases by regulating transcription, translation, and protein expression at the genetic level, positioning RNA-targeted therapeutics as a transformative...
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Structure-Guided Design of a Bioactive Covalent Small Molecule Targeting a Riboswitch | Journal of the American Chemical Society @chemuoft
@UofT @UFScripps @CUBoulder @CUBoulderCHEM
https://t.co/BZOHLDV8iX
pubs.acs.org
Small molecule ligands targeting structured RNA elements hold promise for modulating RNA function, serving as chemical probes and potential therapeutics. In this study, the characterization of...
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Our 2nd @J_A_C_S paper today! Using structure-guided design to create a covalent ligand targeting the FMN riboswitch. The compound is an inverse agonist linked to changes in RNA folding. Grateful for Chungen and Rob Batey’s group collaboration. 🔗
pubs.acs.org
Small molecule ligands targeting structured RNA elements hold promise for modulating RNA function, serving as chemical probes and potential therapeutics. In this study, the characterization of...
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Huge congrats to: 🙌 Sandra Kovachka (synthesis & biology) 🙌 Jielei Wang (chemical probing & folding) 🙌 Amir Taghavi (computation) And to our AViDD collaborators (Arnab, Sumit, Karen) + all coauthors. This is the start. 🔗
pubs.acs.org
The SARS-CoV-2 frameshift stimulation element (FSE) is a critical RNA structure that is essential for viral replication and represents a promising target for antiviral intervention. Here, Chemical...
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This is a platform: 🔹 Chem-CLIP covalent probes 🔹 Competitive DMS mapping 🔹 Cryo-EM alignment Together, they let us read & write covalent small-molecule binding to RNA—in vitro & in cells — and leverage the resulting language to design bioactive ligand targeting RNA.
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The future of science is open — and we’re building it together. Introducing Open Science, our new X community where researchers, founders & curious minds collide to explore DeSci, biotech & innovation. Join us ⬇️
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The bioactive compounds mechanism was investigated by RNA folding studies via Deconvolution of RNA Alternative Conformations (DRACO), show these compounds force the RNA into a misfolded, non-functional conformation.
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We didn’t stop there— we expanded the screen effort to understand more broadly what is targetable within the RNA’s surface.
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The experimentally validated pockets overlap with cryo-EM structures. For the first time, we can line up small-molecule binding sites in RNA with structural biology at atomic resolution.
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Using Chem-CLIP covalent probes, we mapped the binding pocket of merafloxacin (a known FSE inhibitor). Competitive cross-linking + DMS chemical probing pinpointed where and how ligands interact with RNA.
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We targeted the frameshift stimulation element (FSE) of SARS-CoV-2—an RNA pseudoknot essential for viral replication. Mess with this RNA → you mess with the virus.
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🚨 New in JACS! We show that covalent probes can reveal druggable small-molecule pockets in RNA—validated by cryo-EM—and design compounds that inhibit SARS-CoV-2 by misfolding its RNA. Read paper here - Congrats to Amir, Sandra & Jielei 👏 🔗 https://t.co/gX1LKQhOOD Read 📷
pubs.acs.org
The SARS-CoV-2 frameshift stimulation element (FSE) is a critical RNA structure that is essential for viral replication and represents a promising target for antiviral intervention. Here, Chemical...
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Important, Prof. Rivas has done amazing work. Knowing evolution and covariation is most important and often An Overlooked and under appreciated aspect of rna structure annotation/validation!
CaCoFold-R3D: a probabilistic model that predicts RNA 3D motifs and secondary structure using evolutionary information. https://t.co/MLlxPadNDt
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Abraham Watkins Law Firm is incredibly honored to have represented a remarkable family who suffered unimaginable tragedy — the loss of a loved one and life-altering injuries. This $60 million mid-trial settlement brings justice and closure to a family that placed their trust in
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A tale of ambition, tragedy and horror. Join Frankenstein’s dark journey in my free, condensed audiobook of Mary Shelley’s classic. Dare to listen?
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@UFHealth @UFHealthCancer All studies lead by Shiyu Jiang and Amirhossein Taghavi. One of their many innovations was the development and use of a decay library and strategy.
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