Jeroen Bugter
@JeroenBugter
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PostDoc @TumTransla @TU_Muenchen | functional genomics | phenotypic plasticity | GI cancer | Wnt signaling | organoids | @UMCU_CMM alumnus
Munich, Germany
Joined January 2018
New Article! Investigating non-proliferative cell states with inducible CRISPR screens https://t.co/kt5T5rJhwq
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Great work by Michaela below 👇, discovery of an important new player in oncogenic WNT signaling and potential therapeutic target in APC mutant CRC. Happy to have contributed a tiny part to solving this puzzle 🧩
🥳I am beyond to finally share the story of my PhD out now: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer https://t.co/Rsut9zmUq2 Lets have a little look what we found: 🧵1/11
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USP10 emerges as a unique therapeutic target in APC-truncated #ColorectalCancer 🔬 https://t.co/0LqpFmDeuO
@DiefenbacherL
#OpenAccess
nature.com
Oncogene - USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer
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Looking for PhD students/postdocs for my newly opened lab at the Institute of Human Biology of #Roche in Basel. We work on human lung, liver and gut #organoids. Send email + CV + motivation letter to hans.clevers@roche.com with header #IHB
https://t.co/5Ki03fy4NH
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Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations @MadelonMaurice @JeroenBugter @UMCU_CMM
https://t.co/IX87qT3mHW
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Our paper exploring the different mechanism and selectivity of Frizzled regulation by the presumed paralog tumor suppressor genes RNF43 and ZNRF3 has been published! No time to read? I tried to summarize the main message in a one minute video 👇
Transmembrane E3 ligases RNF43 and ZNRF3 selectively target specific Frizzled receptors to suppress WNT signaling, offering an explanation for the cancer tissue-specific distribution of RNF43 and ZNRF3 mutations @MadelonMaurice @JeroenBugter @UMCU_CMM
https://t.co/WFgn2YQ6KB
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Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: https://t.co/0AvDkk9R3S Let’s dive in!
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Dear Tweeps, the Schewe lab is looking for new colleagues at multiple levels!! For the postdoctoral position in the project shared with @JensPuschhof please apply until the 7th May. We are excited to welcome you! Please RT.
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Very grateful to be awarded a NWO Rubicon grant! This allows me to continue my postdoctoral work on 'shape-shifting cancer cell' and develop phenotypic CRISPR screening systems @TumTransla @TU_Muenchen to investigate phenotypic plasticity in colorectal cancer.
Seventeen recently graduated scholars can do their research at foreign research institutes thanks to a Rubicon grant from NWO and ZonMw. For many researchers, experience abroad is an important step in their career. Read more about the awarded projects: https://t.co/vkrwNc1TIi
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A method for genome scale lncRNA screening using CasRx was developed by Ronald Rad, Juan Montero and colleagues @DKFZ, @TU_Muenchen. https://t.co/sbQLGXHkVX
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Hora est! Last tuesday I successfully defended my PhD thesis @UniUtrecht and received my Dr. title. Looking back at a wonderfull day with friends, family and colleagues. Thanks to @MadelonMaurice and everyone involved for giving me this opportunity.
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https://t.co/cfW978AwPw Very excited to share our latest preprint on the 1st functional characterization of OnF reprogramming in CRC, its relevance and therapeutic implications @GuccioneLab @lab_marine @ggargiul_2020 @owen_sansom @Nickbar36316207 Â #CRC #phenotypicplasticity(1/13)
biorxiv.org
Targeting cancer stem cells (CSCs) is crucial for effective cancer treatment[1][1]. However, the molecular mechanisms underlying resistance to LGR5+ CSCs depletion in colorectal cancer (CRC)[2][2],...
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Excited to share a new @trendscancer review: ‘Plastic Persisters: Revival Stem Cells in Colorectal Cancer’. (1/9) https://t.co/ezDE9CRaxG
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Very excited to share two papers published today in @CellCellPress describing stem cell plasticity in CRC. (1/22) https://t.co/jQxR7PCwh7
https://t.co/P9QaEsqkko
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[Rnf43 & Daam] >10 years of work in four different countries. It is a beautiful story about how Wnt regulators coordinate both canonical and non-canonical Wnt pathways. RZ mutant is tumorigenic, but D12 mutant is not due to lack of NC Wnt signaling.
science.org
Daam1/2 interacts with RNF43 to coordinate canonical and noncanonical Wnt during intestinal secretory cell differentiation.
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Another chapter of my PhD work is now online
E3 ligases RNF43 and ZNRF3 display differential specificity for endocytosis of Frizzled family members https://t.co/GDC8rduUFh
#biorxiv_cellbio
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Please help my wife finding a new job opportunity in Munich (medical advice, consulting, research) by sharing this message or contacting her if you know of anything. Check her LinkedIn post below 👇 https://t.co/i4XPxPETMs
linkedin.com
✨ LOOKING FOR A NEW JOB IN MÜNCHEN ✨ and I could use your help!  My husband and I recently moved to Munich and I am excited to explore new horizons! Despite being a medical doctor by profession, I...
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