Oncogene Journal
@oncogenejournal
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Oncogene aims to make substantial advances in our knowledge of processes that contribute to cancer by publishing outstanding research.
London
Joined July 2018
A new study shows NeuroD1-driven cholesterol biosynthesis emerges as a critical axis in hepatocellular carcinoma progression. Read more! .🔗
nature.com
Oncogene - NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation
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A study identifying a novel, GEMIN6/AURKB axis-mediated mechanism underlying the progression of TFE3-rearranged renal cell carcinoma. #KindeyCancer.
nature.com
Oncogene - LGI3 promotes the progression of TFE3-rearranged renal cell carcinoma through GEMIN6/AURKB axis
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A study identifying a novel kinase-substrate interactive platform for HOMER3 to orchestrate YAP1 activity in #ProstateCancer .
nature.com
Oncogene - HOMER3 orchestrates SRC-YAP1 activity that promotes tumor cell growth and antagonizes anti-tumor immunotherapy in prostate cancer
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The Slc7a5-Trp metabolic pathway boosts T cell activation and effector function boosting anti-tumour immunity. 🔬
nature.com
Oncogene - Slc7a5 promotes T cell anti-tumor immunity through sustaining cytotoxic T lymphocyte effector function
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A promising new strategy to halt cancer invasion and metastasis:.Ras-binding peptide, S-016-1034, selectively inhibits mTORC2.
nature.com
Oncogene - Leveraging RAS-mSIN1 interaction to selectively inhibit mTORC2 employing competitive RAS binding peptide: implications in breast cancer metastasis
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RCN3 was found to regulate the PI3K-AKT-mTOR-S6 signalling pathway by enhancing phosphorylation of key proteins, highlighting its role in #ColorectalCancer.
nature.com
Oncogene - RCN3 functions as a tumor promoter in colorectal cancer by modulating the GRP78-PI3K-AKT signaling pathway
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IQGAP3, highly upregulated in many cancers, identified as a novel mediator of β-catenin stabilization. #OpenAccess #CancerResearch.
nature.com
Oncogene - Wnt target IQGAP3 promotes Wnt signaling via disrupting Axin1-CK1α interaction
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Could BST2 be the key regulator of membrane-driven radioresistance in #Glioblastoma?.
nature.com
Oncogene - Membrane flexibility induced by BST2 contributes to radioresistance in glioblastoma
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A novel mechanism by which MAFB promotes #OvarianCancer progression through cytoskeletal remodelling and immune suppression.
nature.com
Oncogene - Activated MAFB in ovarian cancer promotes cytoskeletal remodeling and immune microenvironment suppression by interfering with m6A modifications through WTAP competition
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In our latest issue @Hiroshige_Doya and co-workers reveal that NEAT1 promotes immune evasion from macrophages via CD24 in #LiverCancer.
nature.com
Oncogene - Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer
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A new study from @uniklinik_hd identifying the role of ALDH1A3 in nuclear metabolic-epigenetic programming in basal-like #PDAC #OpenAccess.
nature.com
Oncogene - ALDH1A3 promotes aggressive basal-like pancreatic cancer through an AP-1/RUNX2 enhancer network
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🔬A study elucidating the role of the LIMK2/MST4/NPM1 pathway in #cancer progression and establishing a novel therapeutic paradigm for broad-spectrum anticancer intervention. #OpenAccess.
nature.com
Oncogene - LIMK2 promotes centrosome clustering and cancer progression by activating MST4-mediated phosphorylation of NPM1
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A new study showing that the Epstein-Barr Virus protein EBNA1 hijacks the oncogene MUC1-C to promote viral latency and #GastricCancer progression. Targeting MUC1-C could offer a new therapeutic approach in EBV-associated cancers. #EBV #OpenAccess.
nature.com
Oncogene - MUC1-C auto-regulatory complex with EBNA1 is responsible for latent Epstein-Barr virus-associated gastric cancer progression
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DNA polymerase epsilon loss increases DNA damage and induces p21-mediated cellular senescence to limit tumour formation in CIC::DUX4 #sarcoma.
nature.com
Oncogene - The CIC::DUX4 oncoprotein maintains DNA integrity through direct regulation of the catalytic subunit of DNA polymerase epsilon (POLE)
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The PKA/SPP1 axis is a promising biomarker for identifying prostate cancers that could develop resistance to AR-targeted therapies, pointing to new treatment strategies. #Biomarkers #PCaResearch. @PblSanchis @ggueron @AgusSabater @iquibicen .
nature.com
Oncogene - PKA-driven SPP1 activation as a novel mechanism connecting the bone microenvironment to prostate cancer progression
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Overexpressed GPS2 drives colorectal cancer (CRC) progression by reprogramming lipid metabolism through the LATS1-YAP axis, highlighting novel therapeutic targets for metabolic intervention. 🔗 Read more in this article: .
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High LINC00654 expression in ovarian cancer (OC) is linked to poor prognosis and promotes #cancer progression by stabilizing oncogenes through the HuR/VASH2/TGF-β pathway, offering new therapeutic targets. Read now >>>>.
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Research at @IBUB_UB found that combining Palbociclib and a Glutaminase inhibitor has a strong synergistic effect, preventing #resistance and significantly reducing tumor growth in #colorectal cancer cells. Read the article here >>>>>
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A new article shows how tumor-associated #macrophages' extracellular vesicles drive regulatory T cell differentiation and #glioma progression, revealing potential new therapeutic targets for combating this type of tumor. Read now 🔗.
nature.com
Oncogene - Unveiling the role of TAM-derived extracellular vesicles in glioma progression through Treg polarization and immune suppression
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New study led by @EinsteinMed researchers reveals that CSF-1/CSF-1R signaling plays a crucial role in #breast cancer metastasis by regulating TMEM doorway function, offering potential new targets for treatments. Read now >>>
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