This study shows that meiotic HORMA domain proteins from two aquatic animals possess similar domains that bind DNA and may specifically recognize a key chromatin modification.

For the first time, the Uch, homologue of UCH-L1 in Drosophila was demonstrated that play a crucial role in the development of Drosophila eye cell types and the functions in a manner related to Rhomboid-1 in the Drosophila EGFR pathway.

Live imaging of Rad51 revealed that rad54 mutant cells not only accumulate Rad51 but also transmit Rad51 aggregates to daughter cells, which likely causes intergenerational genome instability.

The -10 region adjacent to open reading frames is a common expression pattern in Deinococcus-Thermus .

SAS-6 promotes invasion through YAP pathway activation @CenGem_Brunel @BrunelResearch @Bruneluni .

This study shows that gastrulation in Acropora species, though morphologically conserved, involves divergent transcriptional programs, supporting the concept of developmental system drift.

CHI3L1/Chil1 is a pro-inflammatory protein that offers tissue protection at normal levels but can promote tumors when overexpressed, making it a viable yet context-dependent therapeutic target. #CancerResearch #Therapeutics

The Authors demonstrate that altering a single residue in the RING domain greatly impacts ubiquitin transfer ability of RING E3 ligase; as a framework for verification, they combine functional, biophysical, structural, and cellular assays @CRUK_SI

Exploring the structure of the spermatid manchette and its function as a transport framework. #CellBiology #Research @ReviewCommons.

Epigenetic liquid biopsies reveal endothelial turnover and erythropoiesis in asymptomatic COVID-19 @ReviewCommons .

Integrative transcriptomic analysis reveals oligodendrocyte lineage switching in multiple sclerosis

This study reveals that the promoter -10 region adjacent to open read frames for gene expression via leaderless mRNA constitutes an important mode of expression in Deinococcus-Thermus phylum.

RT @Mark_A_Nakasone: Happy to share our study "Tuning ubiquitin transfer by RING E3 ubiquitin ligases through the linchpin residue" now #op….

High-content pipeline evaluating YAP/TAZ-TEAD inhibitors in mesothelioma using isogenic models, advanced morphological profiling, and genetic response analysis, revealing drug specificity and compensatory pathways

CHI3L1/Chil1 is a pro-inflammatory protein that at physiological levels is tissue protective, while upregulated expression is tumourigenic; rendering it a valid but context-sensitive therapeutic target.

Epigenetic liquid biopsy reveals hidden tissue damage in COVID-19. Even asymptomatic patients show signs of vascular and red blood cell turnover. This opens a new window into disease biology and clinical course. @ReviewCommons .

Cryo-electron tomography and proteomics reveal that the manchette perinuclear ring thickens as the structure constricts, actin filaments are intercalated in the manchette microtubules and dyneins play a role in intra-manchette transport @ReviewCommons

Mechanistic study on RING E3 #ubiquitin ligases in LSA, from @CRUK_SI comprehensively investigates the role of the linchpin residue. Demonstrating activation of E3 ligase and concepts for protein design, along with a framework for methods/.

Acute MYC over-expression during human B-cell differentiation into plasma cells reveals that MYC depends on transactivation domain amino acid W135 to drive an aberrant antibody secreting cell state @LIMRLeeds @LeedsBRC.

Integrative analysis of single-nucleus RNA sequencing with machine learning and cell communication analysis reveals molecular crosstalk between oligodendrocytes and immune cells in multiple sclerosis, identifying potential therapeutic targets.