Sephin1, an UPR pathway modulator, mitigates TDP-43 cytoplasmic localization and toxicity in ALS motor neurons, improving their survival and showing potential as a therapeutic for ALS.

DEK promotes mammary hyperplasia and is associated with H3K27me3 epigenetic modifications @LMPriVin_PhD @CincyResearch and @CincyChildrens @ReviewCommons.

The July issue is here! Learn about lipid flippases regulating Golgi membrane curvature and lysosome acidification by HIV Tat. Find new insights on inherited mutations linked to leukemia, predicting risk of infection in transplant recipients, and much more

Have you ever wondered how hydroxyurea impacts cellular processes? It plays a crucial role in modulating thiol-disulfide homeostasis within the yeast endoplasmic reticulum, a key player in protein folding and cellular stress responses.

PSME3 Regulates Migration and Differentiation of Myoblasts.

Check out this recently published paper in LSA:.GSK3A promotes human adenovirus replication and phosphorylates viral L4-22K protein.

The Dek histone chaperone promotes mammary gland development through the regulation of proliferation-driving cell cycle genes and deposition of H3K27me3 epigenetic marks. @LMPriVin_PhD @CincyResearch @CincyChildrens @ReviewCommons.

Take a look at this Research Article published in LSA:.Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation .

Discovery of a novel ESS element sheds light on the mechanism of aberrant CFTR exon 9 splicing via hnRNP A1 binding .

Human GRB10 lacks the PPGΦ motif needed to bind GIGYF2—unlike in mice. This challenges previous studies linking GRB10–GIGYF2 interactions to human disease. #proteins #GRB10 #GIGYF2 #biomed.

This study reveals that hydroxyurea selectively inhibits ER-associated degradation of misfolded luminal proteins by modulating thiol-disulfide homeostasis in budding yeast.

In this study, the spatial distribution of mitochondrial-encoded RNAs is investigated and shows that upon transcription arrest, RNAs form granules that show protectivity for transcripts. @Harvardmed @fiddle .

Glycogen synthase kinase 3α (GSK3A) is identified as a crucial and broad-spectrum host factor promoting respiratory HAdV replication, particularly Species B, and phosphorylates viral L4-22K at S78 and S81 residues.

The non-canonical proteasome regulator PSME3 binds extensively to active promoters in undifferentiated myoblasts and regulates both cell migration and myotube formation during myogenesis.

Characterization of a novel IL34 loss of function model reveals overlapping functions of CSF1 and IL34 on CSF1R in the brain and periphery of the rat.

Check out this recently published paper in LSA:.The Ragulator complex and lysosomal calcium release are crucial for cell migration

A novel NRF2 activator in combination with an angiotensin receptor blocker prominently prolonged the lifespan of an Alport syndrome mouse model.

The study identifies CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors and co-repressors that balances the expression of inflammatory genes. @FranziGmuc @helmholtz_diabc @crc_1064 @TU_Muenchen .

Discovery of a novel ESS element sheds light on the mechanism of aberrant CFTR exon 9 splicing via hnRNP A1 binding.

Human GRB10 protein, unlike its mouse counterpart, lacks a PPGΦ motif and cannot bind to GIGYF2. These findings question the published literature that links GRB10/ GIGYF2 binding to human disease.