Gaetano Gargiulo & ggargiul.bsky.social
@ggargiul_2020
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Scientist, cancer researcher, group leader @MDC_Berlin, studying brain & lung tumors and synthetic genetics, occasionally cooking and supporting Inter FC
Berlin
Joined December 2020
Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive brain tumor state, the mesenchymal glioblastoma. Our technology is generally applicable to complex phenotypes! Thanks to the team/funders!
aacrjournals.org
A genetic tracing method using synthetic reporters comprised of glioblastoma subtypespecific cis-regulatory elements allowed mapping of cell states and fate transitions.
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Congrats @GiorgioSeano & team! Happy I could support this very interesting piece of work!.
🧠 Why does glioblastoma always outsmart treatment? In our paper, we identified proneural–mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. Short walkthrough below. Let’s dive in! 🧵 (1/9)
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Finally! Congrats @FilbinMariella & team!.
Excited to share our new story on drivers and communication networks in a lethal tumor in young children called ETMR. Fantastic collaboration with @hovestadt and team! @DanaFarber @BostonChildrens @DFBC_PedCare @broadinstitute .#gograyinmay #endbraincancer 👇🏻👇🏻👇🏻.
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Congrats @FilbinMariella & team, very useful to me :).
Excited to see our latest study on the immune landscape of pediatric high-grade glioma patients out! Tweetorial from fabulous @BeccaBeccaDaria below 👇🏻, we hope this will useful to many in the field! @DFBC_PedCare @BostonChildrens @DanaFarber @broadinstitute #endbraincancer.
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🖤💙.
WE'VE JUST WITNESSED THE HIGHEST-SCORING, AND QUITE POSSIBLY THE GREATEST, CHAMPIONS LEAGUE SEMIFINALS OF ALL TIME!. Inter Milan are heading to the finale. No more words 🎤. #InterBarca
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RT @ElizSMcKenna: At the #AACR25 Minisymposium on Multiomic Integration for Cancer Evolution & Therapy? This @CD_AACR commentary by @ggargi….
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RT @samantha_pretto: Very excited to share that the work of my PhD, where we engineer T cell metabolism to improve their antitumoral activi….
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Great to see this out Hellmut!.
Angiocrine signaling is rocking - pericrine signaling is the new kid on the block: Hepatic stellate cells control liver function (‘HSCs make the liver great again’) – now published @Nature (. Fantastic collaboration with the @RobSchwabe lab @ColumbiaUniv.
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RT @humantechnopole: 📢 Submit your abstract by 16 Feb for the chance to present your work through a talk or poster and don’t miss the "Meet….
humantechnopole.it
This groundbreaking conference aims to engage the leading communities from the main fields of research our institute is pursuing in Neurogenomics, focusing on the neurodiverse human condition and its...
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RT @gminniti2012: Our @EANOassociation annual meeting Is the best place for sharing our neurooncology research and clinical experience ln a….
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"EMT favours the emergence of genomic-unstable, highly fit tumour cells" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!
nature.com
Nature - Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and...
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Above all, I find it incredibly inspiring that a scientist with four decades of groundbreaking work is still leading discoveries, firsthand, literally. For some, curiosity and rigor never age. This one is special 👏.
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Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.
science.org
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)...
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RT @michelle_monje: 1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc @TaraBarronPhD det….
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RT @catgyoung: Distilling the potential impact of science based on a title is so dangerous. Some of the biggest biomedical breakthroughs c….
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Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!.
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the synthetic locus control region for this study was designed using
nature.com
Nature Communications - Descriptive data in biomedical research are expanding rapidly, but functional validation methods lag behind. Here, authors present Logical Synthetic cis-regulatory DNA, a...
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Proud to see our lab’s work contribute to this fantastic study, and specifically: "[. ]We have recently developed a new strategy to genetically trace cell fate transitions within a heterogeneous tissue37,38 [. ]" Check it out! 👇.
Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder @Sleemmzz A huge thanks to all our collaborators @ggargiul_2020 @nickbar36316207 @owen_sansom @NIHFunding
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RT @GuccioneLab: Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder @Sleemmzz….
nature.com
Nature Genetics - Oncofetal (OnF) reprogramming, driven by YAP and AP-1, induces phenotypic plasticity and therapy resistance in WNT-dependent colorectal cancer (CRC). Targeting the OnF state in...
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RT @Sleemmzz: Big thanks to @GuccioneLab @Nickbar36316207 @lab_marine @ggargiul_2020 @owen_sansom for the fantastic collaboration, and to….
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