Gaetano Gargiulo & ggargiul.bsky.social
@ggargiul_2020
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Scientist, cancer researcher, group leader @MDC_Berlin, studying brain & lung tumors and synthetic genetics, occasionally cooking and supporting Inter FC
Berlin
Joined December 2020
Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive brain tumor state, the mesenchymal glioblastoma. Our technology is generally applicable to complex phenotypes! Thanks to the team/funders!
aacrjournals.org
A genetic tracing method using synthetic reporters comprised of glioblastoma subtypespecific cis-regulatory elements allowed mapping of cell states and fate transitions.
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Why does the naked mole rat have the longest lifespan and healthspan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing
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Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: https://t.co/rRu6RYpNWX. (1/3)
nature.com
Nature Cancer - Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic...
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Now online in @CD_AACR: An Autochthonous Model of Lung Cancer Identifies Requirements for Cellular Transformation in the Naked Mole-Rat - by Alyssa Shepard, Daniel Lester, @LabKissil, and colleagues https://t.co/YQA1E3cyf9
@MoffittNews
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Congrats @GiorgioSeano & team! Happy I could support this very interesting piece of work!
🧠 Why does glioblastoma always outsmart treatment? In our paper, we identified proneural–mesenchymal hybrid glioblastoma cells that are resistant to therapy and dependent on nuclear import. https://t.co/kBiblbpsVA Short walkthrough below. Let’s dive in! 🧵 (1/9)
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Finally! Congrats @FilbinMariella & team!
Excited to share our new story on drivers and communication networks in a lethal tumor in young children called ETMR. Fantastic collaboration with @hovestadt and team! @DanaFarber @BostonChildrens @DFBC_PedCare @broadinstitute
#gograyinmay #endbraincancer 👇🏻👇🏻👇🏻
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Congrats @FilbinMariella & team, very useful to me :)
Excited to see our latest study on the immune landscape of pediatric high-grade glioma patients out! Tweetorial from fabulous @BeccaBeccaDaria below 👇🏻, we hope this will useful to many in the field! @DFBC_PedCare @BostonChildrens @DanaFarber @broadinstitute #endbraincancer
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🖤💙
WE'VE JUST WITNESSED THE HIGHEST-SCORING, AND QUITE POSSIBLY THE GREATEST, CHAMPIONS LEAGUE SEMIFINALS OF ALL TIME! Inter Milan are heading to the finale. No more words 🎤 #InterBarca
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At the #AACR25 Minisymposium on Multiomic Integration for Cancer Evolution & Therapy? This @CD_AACR commentary by @ggargiul_2020 Michela Serresi & @lab_marine introduces a framework recognizing tumors as comprising driver, passenger, & trailer cell states https://t.co/HLcmTKH3O9
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Very excited to share that the work of my PhD, where we engineer T cell metabolism to improve their antitumoral activity, is finally out in ✨ @NatMetabolism 🙏Huge thank you to @MazzoneLab and all the collaborators @vib_ccb @KU_Leuven 🔍—>
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Great to see this out Hellmut!
Angiocrine signaling is rocking - pericrine signaling is the new kid on the block: Hepatic stellate cells control liver function (‘HSCs make the liver great again’) – now published @Nature ( https://t.co/XtrxO0UmAA). Fantastic collaboration with the @RobSchwabe lab @ColumbiaUniv.
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📢 Submit your abstract by 16 Feb for the chance to present your work through a talk or poster and don’t miss the "Meet the Speaker" sessions to connect with world-class experts! 👉Neuroimmunology 👉Stem Cell/Organoid Models 👉Cancer Neuroscience & beyond! https://t.co/9TUAzJqjsM
humantechnopole.it
This groundbreaking conference aims to engage the leading communities from the main fields of research our institute is pursuing in Neurogenomics, focusing on the neurodiverse human condition and its...
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Our @EANOassociation annual meeting Is the best place for sharing our neurooncology research and clinical experience ln a great multidisciplinary conference with hundreds of Experts from all Europe
🚀Abstract submission for #EANO2025 is open! Share your #NeuroOncology research at the 20th #EANO Meeting in Prague, Oct 16-19, 2025. We can't wait to see your contributions! 🗓️ Deadline: April 30, 2025, 23:59 CEST. 🔗 Details: https://t.co/9nsp69rc2k
#btsm #braintumor
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"EMT favours the emergence of genomic-unstable, highly fit tumour cells" Exceptional work addressing a classic chicken & egg paradigm in cell-state-driven tumor evolution. Congrats Gianni, Luigi & teams!
nature.com
Nature - Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and...
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Above all, I find it incredibly inspiring that a scientist with four decades of groundbreaking work is still leading discoveries, firsthand, literally. For some, curiosity and rigor never age. This one is special 👏
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Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution.
science.org
Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)...
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1/ Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc @TaraBarronPhD detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵 Open access link: https://t.co/n6kvjrVrjb
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Distilling the potential impact of science based on a title is so dangerous. Some of the biggest biomedical breakthroughs came from research that, at first glance, seemed ‘pointless or unrelated. Here are a few that I'm sure might have caused an uproar in the headlines:
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Who knew they’d give you more than cavities? 😅 - great to see this on the cover @GuccioneLab!
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the synthetic locus control region for this study was designed using
nature.com
Nature Communications - Descriptive data in biomedical research are expanding rapidly, but functional validation methods lag behind. Here, authors present Logical Synthetic cis-regulatory DNA, a...
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