James Tomkins
@JETomkins
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Researcher with an interest in the application of #omics strategies for unravelling the complexities underlying #neurodegenerativediseases
Joined April 2009
RT @biorxiv_bioinfo: Genetic modulation of immune gene co-expression in the aged mouse hippocampus by the Apbb1ip locus .
biorxiv.org
Ageing is a major risk factor for many neurodegenerative diseases, and the hippocampus is particularly vulnerable to the effects of ageing. To define the transcriptomic changes related to ageing and...
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RT @DEMdeBakker: 🧠 Check out the stunning phenotype below! Glycogen aggregates (black) in the aged mouse hippocampus. Intrigued? Dive into….
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RT @em_ka_gu: In dopamine neurons, 10% of SNCA expression encodes novel open reading frames. Understanding the 3' UTRstructures enabled tar….
biorxiv.org
The role of the SNCA gene locus in driving Parkinson’s disease (PD) through rare and common genetic variation is well-recognized, but the transcriptional diversity of SNCA in vulnerable cell types...
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RT @UKDRI: That's a wrap on day 2 of our Parkinson's ECR meeting - fantastic sessions on cell models and big data, plus an important discus….
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RT @UKDRI: Great to welcome over 100 researchers to our Parkinson's ECR meeting in collaboration with @ASAP_Research today! . Brilliant tal….
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RT @ChemCambridge: AI speeds up drug design for Parkinson’s by ten-fold: Researchers have harnessed the power of artificial intelligence t….
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RT @BabrahamInst: The Graduate Studies Office nominated Ellie, Caitlan and Oishee. "As student representatives, they hold a vital role in s….
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RT @PD_BrainMap: 📢 Recent preprint from @ASAP_Research Team Wood, led by @SteveTheChemist @LabGandhi @LucienWeissLab showcasing ASA-PD. A….
biorxiv.org
Parkinson’s disease (PD) is a common neurodegenerative condition characterised by the presence in the brain of large intraneuronal aggregates, known as Lewy bodies and Lewy neurites, containing...
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RT @PD_BrainMap: 📢 Latest paper from @VendruscoloLab @ASAP_Research Team Wood 🎉. Modulation of α-synuclein in vitro aggregation kinetics by….
pnas.org
The misfolding and aggregation of α-synuclein is linked to a family of neurodegenerative disorders known as synucleinopathies, the most prominent o...
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RT @ScienceofPD: New data from @VendruscoloLab & colleagues presents a possible role of alternative splicing in the pathological aggregatio….
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Recent work led by Alex Röntgen @VendruscoloLab characterising the aggregation propensity of α-synuclein alternative splice isoforms. Potential implications for #Parkinsons. Further #proteomics to assess these proteoforms in vivo is a key next step.
pnas.org
The misfolding and aggregation of α-synuclein is linked to a family of neurodegenerative disorders known as synucleinopathies, the most prominent o...
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RT @MRC_Prion: The latest from @MRC_Prion published today in @NatureMedicine👇🏽👇🏽👇🏽. We describe a new type of Alzh….
nature.com
Nature Medicine - A small number of patients who received growth hormone preparations contaminated with seeds of the amyloid-beta protein developed Alzheimer’s disease many years after...
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Huge congratulations @susanna_cogo !!! 🧠 🪱 🔬🧬. #newPI.
⭐Introducing our new Biomedical Sciences lecturer - Susanna Cogo. Susanna was previously a postdoctoral researcher at @UniofReading conducting research into parkinsons and specialises in neuroscience and cell biology. Look out for her in your upcoming practicals and lectures!🥼
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Immersive day of #omics and #biodata yesterday. Particular highlights in the #epigenetics & #longread space, and a captivating fireside chat with Craig Ventor. #FOG2024
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Thanks for the opportunity to share our work on transcriptomic signatures of the #ageing brain today at this #TWIN2PIPSA training school at @ChemCambridge . #transcriptomics #singlecell #bioinformatics #neuroscience.
#TWIN2PIPSA researchers are going to explore different strategies to assess pathological #protein aggregates and how to tackle them during their dedicated Training School, being held at the Centre for Misfolding Diseases at @Cambridge_Uni. Find out more:
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RT @JCBreiter: 🚨New preprint alert🚨. Do you need to detect fluorescent puncta in complex biological samples? Do you find available methods….
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A fun #collaboration on #brain #ageing which stemmed from a Systems #Genetics Summer School last year Take a look, feedback welcome! .
sysgenschool.org
Summer School in Systems Medicine.
Hypobranched glycogen aggregates in hippocampal astrocytes: friend or foe? Read all about it in our latest preprint!. An amazing ongoing collaboration with Alicia Gomez-Pascual, Hui Ng, @DowGlikman @MathiasJucker @robwilliamsiii and many others!.
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RT @ASAP_Research: 📣 Three new #PD datasets are available on AMP PD. New sets include SN Brain Data, Untargeted Proteomics Data, and target….
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RT @Federica_DeLazz: Ever wondered how great discoveries are made? Have a look at this journal club, where I describe how a bit of stubborn….
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