MRC Prion Unit at UCL Institute of Prion Diseases
@MRC_Prion
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Our aim is to combine multidisciplinary and clinical research to understand prion diseases and address areas of public health concern.
33 Cleveland Street, London
Joined November 2021
New podcast🚨we discuss the risks of a future surge in vCJD cases, what it means for public health policy, and advances in biomarkers and treatments with Prof Simon Mead @smead2 @MRC_Prion
https://t.co/vSl7F1kU1y
https://t.co/Kaqhrq8WiP Read the study 👇 https://t.co/8OE6GnTpk4
thelancet.com
Our findings suggest that vCJD is unlikely to re-emerge at significant levels. However, ongoing case ascertainment and scrutiny remains critical due to uncertainties in non-MM incubation and potent...
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A dividing cell model for stable propagation and curing of bona fide human prions. This study introduces the first dividing-cell system that can stably propagate & quantify sCJD prions with potential uses in bioassay, screening and therapeutics https://t.co/Q9H8ykwmQS
@dranihat
biorxiv.org
Prions are assemblies of misfolded proteins that cause transmissible, progressive neurodegenerative disease in humans and other mammals. Human prion diseases have particular public health and...
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Obituary: James Watson (1928-2025) co-discoverer of DNA’s double helix who reshaped modern biology https://t.co/YcweRXxPkO
nature.com
Nature - He helped to reveal the structure of life’s code, transformed science education and research, and remained a deeply controversial figure to the end.
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There are no approved prion disease treatments however international researchers like https://t.co/PN5wKDRWu5
@SangamoTx @prionalliance @ionispharma @MRC_Prion give hope. For treatments being assessed/considered, visit: https://t.co/6ohcIbs5cr
#CJDAwareness #PrionDiseaseAwareness
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Press contact: Charlotte Saigne, Chair – Cure CJD Campaign Email: curecjdcampaign@gmail.com Learn more about prion diseases and PRN100 at https://t.co/E5zRJoeGb6
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12 november: Prion Disease Awareness Day. More to come...
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International CJD Awareness Day
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New paper - Estimating future variant Creutzfeldt-Jakob disease cases in the UK: a cohort-based probabilistic model. What are the remaining risks of vCJD after the BSE crisis? Are we proportionate and prepared in the UK? https://t.co/QPNafdpi2u
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In this new paper from @lizziehill35 PhD we demonstrate that syntaxin-6 regulates intracellular trafficking and export of misfolded prion protein, and that STX6 acts as a modifier of disease susceptibility rather than progression in established disease
link.springer.com
Acta Neuropathologica - Increased expression of syntaxin-6, a SNARE protein involved in intracellular protein trafficking, is a proposed genetic risk mechanism for sporadic prion disease and...
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It was a pleasure to host Sjors Scheres (MRC LMB, no longer on X) to hear about his work characterising the structures of brain protein fibrils in neurodegenerative diseases leading to new classifications and reconsideration of cell and animal models
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This is a good job for people looking to do something a bit different and interesting. Esp those who might want to do PhD as great exposure to lab research meetings. Travel around the UK a couple of times per week to see patients - in depth assessments
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https://t.co/Bl61D9WmZ3 Recruiting at ST1-ST5 for a resident doctor (neurology, psychiatry, other possible) specialising in prion diseases. Multidisciplinary diagnosis and care of patients with rapidly progressing dementia, integrated with interesting research. Friendly team!
uclh.nhs.uk
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Having fun at the Fitzrovia Fête while talking about prions and dementia — complete with Play-Doh brains and DNA necklaces! #ScienceInTheCommunity #DementiaResearch #PrionResearch #UCL #MRC @UCLBrainScience @Manekin93273194 @IoannaChat
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Congratulations to Dr Thomas Cunningham promoted to Associate Professor and Dr Peter-Christian Kloehn promoted to Professor of Molecular Neuroscience at the Institute of Prion Diseases. Well deserved recognition for their work.
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🥳 Huge congratulations to the academic staff & early career staff from the Faculty of Brain Sciences who have been awarded a promotion in this year's UCL academic promotions round. ➡️ https://t.co/nZXJFBbQfM
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National Prion Clinic is recruiting a clinical research fellow. suitable for doctors from FY to preCCT. neurology or psychiatry special interest. Learn about rapidly progressive dementia, prions, multidisciplinary community case management, lots of research. Contact me for detail
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#WorldBrainDay, observed on July 22 every year, aims at promoting awareness and education for neurological disorders. Brain health at every age matters. Not all brain diseases are preventable, but research and care can make a difference #supportresearch
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All of our wet labs are now registered with LEAF, a framework developed by #UCL to support sustainable laboratory operations. By participating in LEAF, labs reduce their carbon footprint, conserve resources and foster an environment that enhances research quality.
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We have once again achieved the Gold award for LEAF (Laboratory Efficiency Assessment Framework) – a fantastic recognition of our ongoing commitment to sustainable lab practices. Congratulations to our Green Team for their great work!👏🏻🏆
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Huge shoutout to our amazing technicians who took part in Day 1 of the UCL Technical Staff Showcase 2025 @UCLEast! đź‘Ź Great to see their work recognised and celebrated. #UCL #TechnicalExcellence #TechsMakeItHappen
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