Mathias Jucker
@MathiasJucker
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Biomedical Researcher Professor @Uni_Tue and @DZNE_en
Tübingen 🇩🇪 & Zürich 🇨🇭
Joined January 2017
We are proud to have contributed to this important work by @prof_horvath lab @Altos_labs with our mouse ageing study.
Excited to share our new paper in GeroScience: a novel ensemble-based epigenetic clock that outperforms existing models in detecting both pro-aging and rejuvenation interventions: #Epigenetics #Aging. @prof_horvath.
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RT @Nature: Replenishing the brain’s natural stores of lithium can protect against and even reverse Alzheimer’s disease. .
nature.com
Nature - Studies in rodents and humans suggest that low levels of the metal contribute to cognitive decline.
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RT @Nature: Nature research paper: How short peptides disassemble tau fibrils in Alzheimer’s disease.
nature.com
Nature - Cryo-electron and atomic force microscopy shed light on how fibrils of the protein tau, which accumulate in the brain of people with Alzheimer’s disease, can be disassembled by short...
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A third type of misfolded Aβ structure has been discovered in the Alzheimer brain, and it is likely that many more exist.
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Almost 50 years after "inoculation" (cadaveric human growth hormone). Where are the misfolded proteins hiding? Cadaveric Human Growth Hormone-Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States
pubmed.ncbi.nlm.nih.gov
We report a case of iatrogenic Creutzfeldt-Jakob disease (iCJD) after a 48.3-year incubation period in a patient treated with cadaveric human growth hormone. iCJD was pathologically confirmed;...
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Curious to know if the repopulation would also work via blood. Nice study!.
A new microglia replacement protocol based on three cycles of a CSF1R inhibitor can treat neurological disorders in mice while avoiding the need for arduous preconditioning, pointing to a safer alternative to bone marrow transplantation. Read more in @ScienceTM:
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RT @alzforum: Among cognitively healthy people who carried a familial #alzheimersdisease mutation, eight years of gantenerumab halved the o….
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Long-term full amyloid removal potentially delayed symptom onset and dementia progression! Findings from the DIAN study.
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Join us for a Master's in Neuroscience in Tübingen, Germany.
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Great summary of the history of early growth hormone preparations and their link to iatrogenic CJD and Alzheimer. Unfolding story of protein mis-folding causing Alzheimer’s disease in recipients of human pituitary growth hormone
academic.oup.com
Abstract. Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were co
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RT @smead2: Sleuths for research fraud make science stronger they have a v important role. However the supposed impact of this story by Pil….
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One more day to apply for these neurodegeneration professorships.
Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @uni_tue @HIHTuebingen and the German Center for Neurodegenerative diseases @DZNE_en Please apply and join us!.
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RT @davidrliu: Today we report in @NatureMedicine the development of a base editing strategy for prion disease, currently a fatal and rapid….
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What a cool read and quiz about confidence! Why probability probably doesn’t exist (but it is useful to act like it does)
nature.com
Nature - All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.
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AI programs exhibit signs of cognitive decline as they age, similar to humans. In fact, this pattern of impairment resembled human patients with posterior cortical atrophy, a variant of Alzheimer’s disease, researchers said 😱.
healthday.com
MONDAY, Dec. 23, 2024 (HealthDay News) -- Humans aren’t the only ones who lose a step or two brain-wise as they age.Artificial intelligence (AI) programs start
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Two flagship chair professorships for neurodgenerative diseases in Tübingen, Germany. Both affiliated with our university @uni_tue @HIHTuebingen and the German Center for Neurodegenerative diseases @DZNE_en Please apply and join us!.
nature.com
The German Center for Neurodegenerative Diseases (DZNE) is a world-leading internationally oriented research center in the Helmholtz Association, c...
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Most of what we know today about "prion-like" was inspired by the "real prions"; what is still missing is an understanding of how "real prions" and "prion-likes" cause neurodegeneration @NIHAging funding😀.
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Wonderful summary of our results, thank you @alzforum. NfL is becoming so important as a readout in clinical Alzheimer trials! Do CSF and Plasma NfL Diverge After Alzheimer’s Disease Onset?
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The prion principle and Alzheimer’s disease | Science
science.org
Similarities to molecular mechanisms underlying prion diseases may help to refine Alzheimer’s disease therapies
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Now that #lecanemab (#Leqembi) has been approved in Europe, we have updated our #Alzheimer game! Play and find out when is the best time to start immunotherapy. Play at -->
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