Dennis de Bakker
@DEMdeBakker
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Researching #neurodegeneration in #killifish as a postdoc in @valenzanolab @dariovalenzano_ @LeibnizFLI. Former lab member of @J_Bakkers @_Hubrecht
Joined December 2010
Exciting to see our recent preprint featured in Nature News! Huge thanks to Chris Simms for the great coverage of our work—check it out below 👇. 🔗 Article: .📄 Preprint:
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RT @J_Bakkers: 🫀 Zebrafish protein unlocks dormant genes for mammalian heart repair. Work by @Bouwman @deBakker et al published in @Nature….
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How come zebrafish can regenerate their hearts after injury, but humans cannot? ❤️🩹 Part of the answer lies in the activation of a gene called hmga1a!. Explore our latest paper here: or check out the summary of our findings below!.
Researchers from @BakkersLab have successfully repaired damaged mouse hearts using a protein from zebrafish. This study marks a promising step toward regenerative therapies to prevent heart failure. Read more @DEMdeBakker .@BouwmanMara .@J_Bakkers
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Thrilled to share our work on gut microbes and brain aging in turquoise killifish at the Aging Microbiota Conference 2024! Honored to receive the Poster Prize—thank you! 🏆 Exciting times for the emerging field of Microbes and Aging! #AgingResearch @microverse_exc @LeibnizFLI
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RT @AOri_lab: In a new preprint from my lab @LeibnizFLI we found that polyamines sustain the regeneration of the intestinal epithelium in….
biorxiv.org
Aging hampers the regenerative potential of intestinal epithelium across species including humans, yet the underlying causes remain elusive. Here, using proteomic and metabolomic profiling of...
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RT @SilviaCat_telan: I am incredibly happy to share our work on the evolution of sperm length in tetrapods, published in @NatureComms. “[…]….
nature.com
Nature Communications - The evolution of sperm length remains an elusive topic. This study applies the Pareto multi-task evolution framework to investigate sperm length variation in relation to...
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This preprint is my first last-author manuscript (!) sprouting from an amazing ongoing collaboration between Alicia Gomez-Pascual, @DowGlikman, Hui-Xin @_slowlettuce, @JETomkins, @Lulu91287772, @KMozhui, @RudiBalling, Rupert Overall, @MathiasJucker, @robwilliamsiii, and others!.
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🧠 Check out the stunning phenotype below! Glycogen aggregates (black) in the aged mouse hippocampus. Intrigued? Dive into our latest pre-print for more insights into the underlying mechanism and pathophysiological relevance! 🔬 #Neuroscience #AgingBrain
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RT @ArckensLab: From specialized non-glial progenitors to mature neurons . We have mapped the adult and aged female killifish telencephalon….
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RT @Tzahore: Take a look at our new article @NatureCVR .looking at Regenerative Senescence in Cardiac Repair.
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RT @LabMoons: First a preprint, now officially published in @AgingCell. Find out more on "Age-related dysregulation of the retinal transcri….
onlinelibrary.wiley.com
Transcriptomic analysis of the ageing killifish retina showed a marked upregulation of processes observed to be altered in the aged human retina and brain, including oxidative stress, gliosis, and...
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RT @ItamarHarel: The ultimate sacrifice? . 🔥Amazing work @NatureAging by Tehila and Eitan, demonstrating that the germline regulates verteb….
nature.com
Nature Aging - Moses, Atlan et al. profile the killifish (Nothobranchius furzeri) gonad using single-cell sequencing and reveal that genetic germline depletion induces sexually dimorphic...
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RT @ValerieMarien1: How does the brain of the fast aging #killifish develop? Find out in our latest preprint! 🐟🧠.
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RT @BakkersLab: We are recruiting enthusiastic postdocs interested in retina #regeneration in #zebrafish.
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RT @_Hubrecht: Congratulations to the Lifelong VISION consortium for receiving a Gravitation grant! In this partnership, scientists will jo….
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RT @dariovalenzano_: Field research in the Gonarezhou National park-studying turquoise killifish in their natural environment. Lots of sci….
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RT @LeibnizFLI: Do you have experience with experimental techniques such as molecular cloning and cell culture work and state-of-the-art te….
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RT @DomenicoFraia: Our updated study on killifish brain aging reveals a widespread reduction in proteins rich in basic amino acids. 📚🔬 No d….
biorxiv.org
Aging and neurodegeneration entail diverse cellular and molecular hallmarks. Here, we studied the effects of aging on the transcriptome, translatome, and multiple layers of the proteome in the brain...
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RT @_slowlettuce: Preprint out now!.So grateful for the guidance and mentorship of profs @robwilliamsiii Rupert Overall and team members @D….
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RT @RongfengC: First pub from my lab is out on @molecology! We analyzed the genetic load on two high quality phased genomes of the critical….
onlinelibrary.wiley.com
While haplotype-specific genetic load shapes the evolutionary trajectory of natural and captive populations, mixed-haplotype assembly and genotyping hindered its characterization in diploids....
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