Thrilled to share this much awaited, exciting work from the @Slotkin_Lab lead by @mcliupeng published in @nature today!!

Excited to share Nona: a unifying multimodal masking framework for functional genomics. Models for DNA have evolved along separate paths: sequence-to-function (AlphaGenome), language models (Evo2), and generative models (DDSM). Can these be unified under a single paradigm? 1/15

Nice paper in @ScienceMagazine apparently showing for the first time that DNA breaks leave lasting epigenetic scars Excitingly, it’s consistent with The Information Theory of Aging & our discovery of this same phenomenon in 1997, 1999, 2008 & 2023 🤣👏🧵 https://t.co/kDmqCO8b4J

Introducing Molview - the ipython/jupyter widget version of nano-protein-viewer🔍:

"MultiCAST, a streamlined platform for rapid and scalable gRNA-directed transposon insertion in bacteria."

The Wilkinson Lab is open for science! @MSKCancerCenter 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

ipython/jupyter widget version of nano-protein-viewer is coming out soon stay tuned!

Agrobacterium-mediated transformation of plants and fungi is enhanced by plasmid copy number variants https://t.co/ryNgs21Rn5 https://t.co/8QqCPLNyDZ

Plant bioengineering can be quite annoying. Look at this crap; the type of agar drastically impacts transformation efficiency. The geometric complexity of all these variables makes for one hell of a ride to find the ideal brew…for each stage of regeneration stage. Lord help us.

IMO it’s not bad that tech folks are building AI for science because they lack the domain expertise to know what’s working. A greater waste is that too many are over-indexing on every poor approach scientists have due to their human limitations and historical baggage. Scaling a

#Internship 📢We are excited to announce the call for the NCBS Winter Research Program! 🥼This 8-10 week research internship program offers students a unique opportunity to engage with cutting-edge research at NCBS. Apply now! https://t.co/bwdXdjAoa5 Deadline: 15th November 2025

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project has been collaborating with many leading biologists who tested BoltzGen at an unprecedented scale, showing success on many novel targets and pushing its limits! 🧵..

🤔How do you design a promoter for stable titration of expression? 💡Try programmable promoter editing with DIAL! 📰Now published at @NatureBiotech 🧵 [1/n] 🔗 below

Come join @maya_m_arce @uchemedoh @zhou_jingtian and start your lab at @arcinstitute as a Science Fellow! Researchers receiving their PhD, MD, or MD/PhD between spring 2024 and summer 2026, are encouraged to apply. Applications are being reviewed starting January 12, 2026.

how a biologist sees the world

Updating my VS Code protein viewer plugin for this new color setting :)

#LatestPublication @harshithcy from @shivaprasad_pv's lab identified the role of transcription factor OsWRKY53 that dictates wound responses in rice. It fine-tunes wound responses by turning on defense-related genes while turning down growth-related ones. https://t.co/7XNFF8N6kI

Thrilled to share our work on transcription initiation and termination being spatially coordinated out today in Science!

Site-specific and efficient RNA editing is achieved with a CasRx editor https://t.co/qzyb2nnmwn https://t.co/p55IvOSw8L

The tidyplots package by Jan Broder Engler (@JanBroderEngler) helps you create clean, publication-ready plots in #RStats with minimal code. Built on ggplot2 and tidyverse principles, it streamlines data visualization with consistent, elegant defaults. https://t.co/0dhuKtuaQ6

LETTER TO THE EDITOR: The action of Arabidopsis DICER-LIKE 2 in plant growth inhibition (Yuelin Liu, Wei Yan, Qianyan Linghu, Huijuan Tan, Hongwei Guo) https://t.co/4BaNq0XZbQ @ASPB #PlantSci