Nadav Ahituv
@NadavAhituv
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Professor, Department of Bioengineering and Therapeutic Sciences, Director, Institute for Human Genetics, UCSF
San Francisco, CA
Joined October 2015
Updated VISTA Enhancer Browser, 7 years in the making, out in @NAR_Open! >4,500 transgenic in vivo enhancer experiments for all your developmental biology, human variation and #evodevo needs. https://t.co/fE861VE3r7
#enhancers #embryos
https://t.co/QxQDzGzBlf
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1/🧵Excited to re-introduce Memento in ( https://t.co/mxycmsOTkr), a scalable method for differential analysis of scRNA-seq data. It provides first-in-class performance in statistical power and calibration for comparing differences in mean, variability, and gene correlation.👇
cell.com
Memento implements a statistical model and a fast resampling procedure to estimate and compare the mean, variability, and correlation of gene expression, allowing for the study of transcription in a...
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Thinking about a PhD using computational power to answer pressing problems in biology and health? @UCSF Biological and Medical Informatics PhD program is recruiting for Fall 2025! Join our info session next Monday Oct 21: https://t.co/jLMUwigeI1.
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Very cool work by @YinShenLab showing how allelic compensation can be used as a regulatory compensation mechanism.
biorxiv.org
Precise transcriptional regulation is critical for cellular function and development, yet the mechanism of this process remains poorly understood for many genes. To gain a deeper understanding of the...
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Beautiful work by @KarissaLHansen and @ElphegeNoraLab on the role of cohesin in enhancer-promoter interactions. Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function
biorxiv.org
Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...
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Beyond stoked to share our latest, entitled “Diversified, miniaturized and ancestral parts for mammalian genome engineering and molecular recording” ! https://t.co/8BtGh7th6P
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Incredibly proud to share that I recently joined @UCSF_BTS @UCSF as an Assistant Professor! This means that the Calderon Lab is now open! Or, more accurately, in the process of opening as I am still unboxing equipment and unraveling giant posters (a last @JSHendure lab gift) 🥳
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It was a lot of fun doing this! Thanks so much @patrick_j_short for hosting me!
Episode 152 of #TheGeneticsPodcast is live 🚀 @NadavAhituv, Director for the Institute of Human Genetics @UCSF talks the history of the non-coding #genome and the power of #CRISPR. Listen now: 🎧 https://t.co/76O2G8KU8s 📽️ https://t.co/wokNn1D4aZ
#SanoGenetics #Genetics
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Our paper describing a scalable method for Multiplex, single cell CRISPRa screening for cell-type specific regulatory elements is now published! https://t.co/XSq2c5rPY8
https://t.co/ENt5kQ3zJz
Exceptionally stoked to share our new work entitled “Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements” ! https://t.co/1Hcg3RrYY4
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Thank you to @KathyGiacomini, Christof Fellmann, David Schaffer, Francine Gregoire, @M_Kyle_Cromer, Emil Kakkis, Andrew Carroll, David Kelley, Danny Wells, Tony Capra, Christina Fan, Andrew Farmer, Wenjun Ouyang, and @YinShenLab for their outstanding 2024 IHG Symposium talks!
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An experimental census of retrons, now published in @NatureBiotech. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%.
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We are recruiting two computational biologists/bioinformaticians with ML expertise and a focus on genomics, variant effects and gene regulatory sequences in staff scientist and postdoc roles in Lübeck, Germany. Please find details here:
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Excited to share the white paper for the IGVF Consortium, supported by @genome_gov Deciphering the impact of genomic variation on function https://t.co/RxudNoG4QG
Understanding the function of an entire genome is no easy task! Most genes likely have more than one function. To understand the functional effects of genomic variation, NHGRI launched a consortium called Impact of Genomic Variation on Function (IGVF). https://t.co/XV1DENtBvy
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Four last days to register! Symposium on 9/9. We have a great lineup of speakers, plenty of time to network and registration is free. https://t.co/7WF2FPO7aM
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Another beautiful story by Ari Daniel (@mesoplodon) @NPR on the Belize bat-a-thon and our work on how fruit eating bats can eat so much sugar and not get diabetes. Amazing work by @GreatWeiShark and Mai Nobuhara! https://t.co/JPWkCx9hEY
npr.org
Bats are able to consume an extraordinary amount of sugar with no ill effects. Scientists are trying to learn more about how bats do it — and whether humans can learn from their sugar response.
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Thrilled to share that I'll be starting a tenure-track assistant professor position at the Department of Genetics, Washington University in St. Louis, in January 2025! @WashUGenetics I am recruiting lab members at all levels. For more details, visit our lab website or check flyer
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Our paper is out today !!! https://t.co/bpjB3o4fiO
@RutgersCABM @NadavAhituv @nir_yosef1 @TakaInoue5 @TalAshuach
link.springer.com
Background Increasing evidence suggests that a substantial proportion of disease-associated mutations occur in enhancers, regions of non-coding DNA essential to gene regulation. Understanding the...
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