GESTALT
@GESTALT_sp
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Global Alliance for Spatial Technologies: an organized whole that is perceived as more than the sum of its parts. Democratizing Spatial-Omics Techs
Everywhere
Joined August 2023
1/ The need for a Global Alliance for Spatial Technologies arises from multiple driving factors, pushing the progress and use of spatial tech across various disciplines. #GESTALT
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Such a pleasure visiting the Department of Cell Systems and Anatomy @UTHealthSA this week! Thank you Professor Yu Luan for inviting me to share our recent work! Glad and honored to meet so many amazing Asian American colleagues. Thank you all for having me! The last photo is a
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🔥 High-plex spatial RNA imaging in one round with conventional microscopes using color-intensity barcodes
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I'm almost at my fundraising goal for ALS and the NYC marathon this Sunday - please donate if you can, and wish me luck!
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Don’t miss out !
Seminar Series – #GESTALT – Global Alliance for Spatial Technologies Next one October 31 2025: Dr. Siyuan (Steven) Wang #RAEFISH!! Read: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution ( https://t.co/12TmzIO3GI)
@SStevenWang
@GESTALT_sp
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Seminar Series – #GESTALT – Global Alliance for Spatial Technologies Next one October 31 2025: Dr. Siyuan (Steven) Wang #RAEFISH!! Read: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution ( https://t.co/12TmzIO3GI)
@SStevenWang
@GESTALT_sp
cell.com
RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.
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@AnnaEnim @CellGenomics @LGMartelotto @JudeNicho @NIH @BWFUND It’s a fantastic technique. Easily the best genotyping + RNA technique available at the moment. Do not sleep on this one!!! Great work @AnnaEnim and @LGMartelotto
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RT @LGMartelotto: YES!!! It’s out! 🔥 One of the most amazingly beautiful collaborations. I’ve admired @AnnaEnim since her original GoT -…
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Mi amigo Chris - @mason_lab, a legend through and through - dives into his lifelong love for genetics, from the Human Genome Project to some of the coolest omics projects on the planet (and off it). He’s the mastermind behind mapping the NYC subway microbiome (hero status
genomeweb.com
Mason likens the path to interplanetary genomics to the building of cathedrals in the Middle Ages: "It's bigger than you, it's kind of humbling in a way."
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Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE | Nature Methods
nature.com
Nature Methods - iSCALE leverages histology and spatial transcriptomics to infer gene expression at super resolution in large tissues.
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I see this photo and can’t stop thinking about the song…“sweat, baby, sweat…” 😅 #XeniumIsOnFire
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Brilliant 🫶 Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution: Cell
cell.com
RAEFISH delivers whole-transcriptome (>20,000 genes) imaging at single-molecule resolution in cells and tissues and enables direct gRNA detection for high-content, image-based CRISPR screens.
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Our RAEFISH spatial transcriptomics technology is now published in Cell @CellCellPress! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were
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@Xiaojie_Qiu @CellCellPress Thank you for your very kind words, Xiaojie! We think this should be compatible with most, if not all, image-based spatial transcriptomic instruments out there, so this should be quite adaptable. Looking forward to collaborating with you and your team too!
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Spatial transcriptomics often raises recurring questions…why do some samples show so few genes, is expression too low, or are we just seeing poor quality tissue? @BrantBassamPhD digs into a unique dataset of 210 CosMx SMI experiments across human, mouse, and primate tissues to
linkedin.com
There are questions in Spatial Transcriptomics (ST) that come up time and again. Questions like “shouldn’t there be more genes expressing?,” “is the level of expression too low to be useful?,” and...
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Loving this… circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics | bioRxiv circVDJ-seq for T cell clonotype detection in single-cell and spatial multi-omics | bioRxiv
biorxiv.org
Monitoring T cell clonality in human tissues provides important insights into adaptive immune response mechanisms in cancer, infectious diseases, and autoimmunity. However, retrieving VDJ sequence...
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Comparing single-cell #SpatialTranscriptomics methods on FFPE human tumor #TissueMicroArray CosMx 1k vs MERFISH 500 vs Xenium-UM/-MM 339 93 common genes lung adenocarcinoma pleural mesothelioma Corr. Bulk RNAseq, GeoMx "better F1-scores with Xenium-MM (median, > 75%) than
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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Join GESTALT @GESTALT_sp Let us learn #SpatialOmics together!😆 https://t.co/VC6NIDp6dL
@DrJasPlummer @ioavlachos @LGMartelotto @NatureGenet 2025 https://t.co/c9Mlfc90mL
nature.com
Nature Genetics - This Comment outlines the creation of the Global Alliance for Spatial Technologies (GESTALT), a collaborative initiative aimed at fostering the growth and standardization of...
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China's BGI Unveils Stereo-cell Technology, Expanding Single-Cell and Spatial Arsenal | GenomeWeb STAMP is versatile, platform agnostic, multiomics enabled, multioplexing capabilities and leverages top-notch R&D teams across multiple vendors..
genomeweb.com
Building on BGI's proprietary DNBSeq technology, Stereo-cell is highly similar to Stereo-seq in workflow while promising to be unbiased and scalable.
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RT @LGMartelotto: Yes, you can very likely plug this into Single Cell Imaging - #STAMP: Single-cell Transcriptomics Analysis and Multimodal…
lnkd.in
This link will take you to a page that’s not on LinkedIn
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