**Please Retweet (Re-X?)** .🔥Postdoc #jobs in Spatial / Single Cell Omics .Looking to become a #leader in #SpatialBiology? .Love NGS & #MachineLearning? #Positions @harvardmed @broadinstitute .#hiring #lab #boston #research #aiml #biotech #Science.

RT @GESTALT_sp: Don’t forget to register to the seminar on June 27 and July 25:. GESTALT - Seminar Series. June 27 - 2025: Dr. Fei Chen.Jul….

Can you do multi-modal multi-million cell single cell studies 𝐰𝐢𝐭𝐡𝐨𝐮𝐭 𝐬𝐩𝐞𝐧𝐝𝐢𝐧𝐠 𝐦𝐢𝐥𝐥𝐢𝐨𝐧𝐬 $$???.🔥STAMP is fire!!🔥.Multi-million cell atlases are now accessible to all.What a milestone! .From @LGMartelotto @hoheyn @DrJasPlummer .

RT @FLGenomics: Community is key when establishing newer technologies. From the scTrends Consortium’s ‘living review’ to GESTALT, a WhatsAp….

RT @alm_o: Thank you @melinda_bachini and @curecc for supporting my @ASCO YIA application and @ConquerCancerFd for funding our study to adv….

ChatGPT prefers humans to be polite! .A lot of discussion about #thankyou and #please when interacting with LLMs such as @ChatGPTapp & @AnthropicAI. Asked ChatGPT 4.0 and it flipped the narrative on where to focus: .the burden is on the developers not users

RT @mason_lab: Introducing the Global Alliance for Spatial Technologies (GESTALT).- a groundbreaking global, open,….

If you're around, ping me at the Other Place at 🦋.

RT @RongFan8: Thrilled to share two @biorxivpreprint papers from my lab and @StimulatedRaman, reporting on the SAME tissue section multi-mo….

RT @LukasValihrach: snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives👏

RT @LGMartelotto: Phew…finally! . snPATHO-seq, a versatile FFPE single-nucleus RNA sequencing method to unlock pathology archives | @CommsB….

STAMP: That's a wrap! Hope it helped.Tried to capture the most common questions I received since the biorxiv. Shout out to @LGMartelotto and the team for the cool tech.

TL;DR Highlights for STAMP, please!.- 10-100+ fold lower cost per cell.- 5-20-fold lower cost per sample.- Rich data for deep cell phenotyping.- Multiple instruments can be reused on the same slide

Be critical, please! STAMP Plus/minus vs scRNAseq?.- Cost (+).- Targeted vs untargeted (+/-).- 50 cells to 3M cells (+).- Expensive instrument (-).- Samples per run (+).- Instrument bottleneck (-).- RNA+Protein+Anything (+).- Nuclei & cells (=).

STAMP: Which spatial assays are compatible?.From the pre-print & discussions with the authors, should be all AND sequential.Imaging-based (Xenium, CosMx, MERSCOPE. ).Sequencing based (Visium (HD, V2). ).Multiplexed IF (PhenoCycler-Fusion, CyCIF, Cell DIVE. )

STAMP: 𝗛𝗼𝘄 𝗹𝗼𝘄 𝗰𝗼𝘀𝘁 𝗶𝘀 𝗶𝗻𝘀𝗮𝗻𝗲𝗹𝘆 𝗹𝗼𝘄 𝗰𝗼𝘀𝘁?.Orders of magnitude vs single cell assays, even when using expensive preps, such as Xenium 5,000 plex or CosMx 6,000 plex.

STAMP: How does it work? How many cells & samples can I analyze?.With some smart tricks, the authors STAMP cells in tight conformations on ANY slide.From 𝟱𝟬 𝗰𝗲𝗹𝗹𝘀 to 𝗺𝗶𝗹𝗹𝗶𝗼𝗻𝘀 per region. From 𝟭 to 𝟮𝟬+ 𝘀𝗮𝗺𝗽𝗹𝗲𝘀 per slide.Image: 2x40K & 1x1M cell STAMPs

𝗦𝗧𝗔𝗠𝗣: single cell (spatial?).Being asked what I think about it (NOT involved). 1) What is STAMP? Should I care about it?.STAMP is a clever way of using 𝘀𝗽𝗮𝘁𝗶𝗮𝗹 𝗮𝘀𝘀𝗮𝘆𝘀 to get 𝗶𝗻𝘀𝗮𝗻𝗲𝗹𝘆 𝗹𝗼𝘄 𝗰𝗼𝘀𝘁 𝘀𝗶𝗻𝗴𝗹𝗲 𝗰𝗲𝗹𝗹 𝗱𝗮𝘁𝗮.

RT @GenomicsCow: We now have a way to use spatial imagers to overcome single cell struggles, with stamp . . And a w….

RT @RongFan8: Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same….