Anna Nam
@AnnaEnim
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Physician-scientist & molecular hematopathologist at Weill Cornell Medicine
Manhattan, NY
Joined October 2018
Pls RT: The Nam Lab at WCM is recruiting post-doctoral fellows to join the growing team! If you're interested in deciphering blood cancers through advanced single-cell technologies, please DM me and visit our website https://t.co/vzml2Llu85 to learn more.
annanamlab.com
The Nam Lab focuses on developing innovative molecular and computational tools to learn how cancers develop. We focus on developing tools that interrogate cancer cells at single cell resolution.
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Leukemia Progression Mapped by New Multi-Omics Tool, GoT-Multi GoT-Multi maps somatic #genotypes and transcriptomes in single cancer cells, revealing more on clonal evolution and therapy resistance @AnnaEnim @WeillCornell
#leukemia #multiomics
https://t.co/eAxXh6hZwc
genengnews.com
GoT-Multi maps somatic genotypes and transcriptomes in single cancer cells, revealing more on clonal evolution and therapy resistance.
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“This technology gives us new power to answer important questions about how #cancers evolve, from pre-cancerous #neoplastic outgrowths to transformation into malignancy and resistance,” Dr. Anna Nam (@AnnaEnim)from @WCMCPathology and the @WCMEnglanderIPM
https://t.co/SMAWp01mIg
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RT @LGMartelotto: YES!!! It’s out! 🔥 One of the most amazingly beautiful collaborations. I’ve admired @AnnaEnim since her original GoT -…
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@CellGenomics @LGMartelotto Congratulations to our incredibly talented post-docs Dr. Minwoo Pak and Dr. Mirca Saurty-Seerunghen! Many thanks to our collaborators, editor @JudeNicho and reviewers including @AlejoFraticelli! Could not have been possible with our funding sources @NIH #hrhr @BWFUND.
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Excited to introduce GoT-Multi, out at @CellGenomics: https://t.co/vV0p7EC9Df! Developed together with the single cell wizard @LGMartelotto, GoT-Multi is a next gen single cell multi-omics - multiplexed genotyping in transcriptomes compatible with FFPE samples.
cell.com
Pak, Saurty-Seerunghen et al. present a method, GoT-Multi, that co-detects single-cell multiplexed somatic genotyping and whole transcriptomes in high throughput from fresh or FFPE samples, overcom...
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Thrilled that our paper is finally in press @ScienceMagazine!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l_cmurphy below. Check out the news feature https://t.co/r1bXqfpPSU and terrific editorial from Dennis Lo
science.org
The cells could be a new source of tumor DNA for liquid biopsies
🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @ScienceMagazine! 🎉 🧽 📖 Read our paper here: https://t.co/CvYSNq2nHj 🎬 Watch a summary: https://t.co/qvuZR3reTj 🧵 Or keep reading for the key points! 🔑 1/19
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Congratulations to our @WCMCPathology colleague Dr. Anna Nam (@AnnaEnim) on earning a new Starr Cancer Consortium Grant for her work "Modulating inflammation to eradicate clonal #stemcells." #Pathology #PathTwitter
https://t.co/KQd0hLFUdJ
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Teams led by Drs. @Ekta_Khurana, Jacob Geri and Anna S. Nam (@AnnaEnim) of @WCMEnglanderIPM, @WCM_MeyerCancer and @WCMCPathology have received awards from the Starr Cancer Consortium to continue their research on cancer biology. Full story: https://t.co/v6LG3aEMSN
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🎉Excited to present our latest work out today @Nature 1.What gives a leukemia its phenotype – the oncogenic driver or the differentiation stage of the cell-of-origin? 2.Why do RAS mutations always happen late in AML? 3.Who will relapse after VEN?
nature.com
Nature - We find that RAS-mutant leukaemia stem cells are resistant to venetoclax, driving clinical resistance and relapse with monocytic features.
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Today is the day 🤩. Thrilled to share our @Nature paper on Th2 function, CAR-T, & 8-year remission!! Huge team effort w/@GruppSteve @carlhjune @MelenhorstLab @Tang_Lab_EPFL, kudos to my postdoc @Zhiliang_Bai
nature.com
Nature - Elevated type 2 functionality in CAR T cell infusion products is significantly associated with maintenance of a median B cell aplasia duration of 8.4 years in paediatric patients...
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Thrilled to report Patho-DBiT, just published in Cell 😊. It allows us to directly “see” all kinds of RNA species on the same clinical FFPE tissue slide, including mRNA, miRNA, snRNA, snoRNA, tRNA, etc, and splicing isoforms, genetic alterations (SNV, CNV, etc). Really a fun,
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Very happy and proud to see this study on PU.1 transcription factor "redistribution" and its mechanistic implications out in @NatureGenet today. Huge congrats to lead author @SamuelJohnTayl1! (recruiters watch out: Sam is on the faculty job market now...!). A big thank you also
Super thrilled to share our article on pharmacological PU.1 repositioning published in Nature Genetics today! Massive thanks to everyone involved! Article -> https://t.co/h0rPMMq8qH A digestible PUree of the main findings (aka Research Brief) -> https://t.co/1IoXUygs5p
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Congratulations, Len and Cecilia!! Grateful to have contributed to this wonderful study with our computational research assistant Chhiring Lama!
Congrats to my postdoc Cecilia Pessoa Rodrigues on her Science paper. We show that dsRNAs from endogenous viral elements bind to TLR3, inducing the don't eat me signal, B2m, on HSCs. This protects the stem cell from phagocytosis by macrophages.
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🥳new pre-print alert! VEXAS syndrome deciphered - From single-cell genotype-to-phenotype mapping aaaall the way to mechanism and therapeutic vulnerability discovery! https://t.co/aeq47hzZ0w
biorxiv.org
Somatic evolution leads to the emergence of clonal diversity across tissues with broad implications for human health. A striking example of somatic evolution is the VEXAS (Vacuoles E1 enzyme X-linked...
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Fantastic tips on starting a #NewLab during today’s @WashUDPS #CAPSiT seminar feat. @AnnaEnim @MMaversMDPhD @SudarRajagopal
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Beyond proud to share my thesis work, out today in @CellCellPress! My deepest gratitude to my amazing co-authors, those who come before me whose beautiful work this is built upon, and my extraordinary advisor, Camilla Forsberg. @Forsberg_Lab
cell.com
With advanced age, platelets generated by a differentiation pathway that shortcuts the canonical progenitor cascade to directly make megakaryotic precursor cells from hematopoietic stem cells cause...
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Our latest paper out @NatureGenet today. Even more mutated genes driving clonal expansions in blood as we age. Additional genes found in @UKBIOBANK confirmed in >10,000 while genomes of blood cell colonies. @calico @sangerinstitute @SCICambridge @doctor_msc
📰 Read ‘Analysis of somatic mutations in whole blood from 200,618 individuals identifies pervasive positive selection and novel drivers of clonal hematopoiesis’ from @jyoti_nangalia @doctor_msc @SCICambridge @Cambridge_Uni @calico in @NatureGenet ⤵️ https://t.co/vb85QN8PFJ
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Targetable leukaemia dependency on noncanonical PI3Kγ signalling | Thrilled to share this work @Nature from the inimitable @QingyuLuoMDPhD, with many in our lab @DanaFarber and great collaborators too. Shareable link: https://t.co/jZWFbFxEkF, journal:
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New paper! We provide a scRNA-seq pipeline for simultaneous gene expression and 3′UTR length analysis. We quantified 3′UTRs in 474 cell types and found that 3′UTR length provides information that is independent of gene expression. https://t.co/hZto8xdfzE
nature.com
Nature Communications - While gene expression analysis is commonly performed, 3′UTR length analysis is limited due to technical challenges. Here the authors provide an open-access analysis...
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Happy to share the final version of our #GAGEseq published today @NatureGenet! The single-cell co-assay for #scHiC and #scRNA reveals 3D genome & gene expression interplay in mouse cortex (also integration w/ #MERFISH) and during human hematopoiesis. 1/3
nature.com
Nature Genetics - GAGE-seq is a joint assay for 3D genome and transcriptome in single cells using combinatorial indexing to increase throughput. Applied to complex tissues, GAGE-seq enables the...
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