The Dobreva Lab
@DobrevaLab
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We study the interplay between genetics and epigenetics in shaping cell identity, plasticity, and resilience during development and in disease.
Heidelberg University, Germany
Joined May 2021
RT @CellStemCell: Online Now! Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothe….
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RT @CellCellPress: Now online! Perturb-Multimodal: A platform for pooled genetic screens with imaging and sequencing in intact mammalian t….
cell.com
Pairing imaging and sequencing to simultaneously measure gene expression and morphological phenotypes in diverse genetically perturbed cells in mosaic animals, Perturb-Multimodal enables systematic...
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RT @Nature: Nature research paper: Metabolic adaptations direct cell fate during tissue regeneration.
nature.com
Nature - Metabolic enzymes of the tricarboxylic acid cycle, such as 2-oxoglutarate dehydrogenase, are differentially expressed in absorptive and secretory lineages, guiding cell fate establishment...
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RT @alantomusiak: Absolutely crazy month for progress in the world of genome instability & DNA repair, especially as pertaining to aging. A….
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RT @z_chiang: The peer-reviewed version of expansion in situ genome sequencing is now out in Science!. The news is bittersweet – when we fi….
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RT @EpigenomeTech: Epigenetics Update - Clonal tracing with somatic epimutations reveals dynamics of blood ageing .
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RT @Nature: Nature research paper: Molecular basis of positional memory in limb regeneration.
nature.com
Nature - A molecular analysis of axolotl limb regeneration has identified a positive genetic circuit that maintains posterior cell identity and can be used to reprogramme anterior cells into...
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RT @pulmonary_news: The @DobrevaLab show that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in #LungCancer.….
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We are excited to share our latest work uncovering how the epigenetic modifier RNF20 links genome stability and metabolic rewiring in lung cancer: @NatureComms
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RT @HelmholtzMunich: Mapping the Future of Organoids 🧠🫁. 👉 Read the original publication in Nature Genetics: What….
nature.com
Nature Genetics - The human endoderm-derived organoid cell atlas (HEOCA) presents an integrative analysis of single-cell transcriptomes across different conditions, sources and protocols. It...
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RT @ScienceMagazine: In a new @SciSignal Review, scientists examine an emerging body of research implicating #SleepLoss as a metabolic diso….
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RT @NatMetabolism: RESEARCH | @NicolaisenSand, B Kiens et al. (@UCPH_Research). Dietary protein restriction in healthy, lean men elicits in….
nature.com
Nature Metabolism - Dietary protein restriction in healthy, lean men elicits an increased energy intake to maintain body weight, which is driven, at least in part, by FGF21-mediated alterations to...
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RT @MariaErmolaev13: Study finds that female body takes longer time to recover from pregnancy and childbirth. Honestly, how is this even su….
nature.com
Nature - Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
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RT @CellPressNews: Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk.http….
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RT @CellStemCell: Online Now! Vascular network-inspired diffusible scaffolds for engineering functional midbrain organoids .
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RT @Vesna_Tod: Check out this interesting Bioengineering conference organized by @NatureConf @natrevbioeng @NatureComms @NatureMaterials @n….
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RT @CellPressNews: Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal….
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RT @NatureCVR: ❤️Our March issue is out❤️Featuring the cardiovascular polypill’s path to the WHO’s Essential Medicines list, tricaprin’s ap….
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RT @NatureCVR: Research| Li et al. show that maternal exposure to a Western-type diet can accelerate atherosclerosis in adult offspring, re….
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RT @McKinseyLab: Heart rate matters. Great collaboration with Mike Bristow and many others. Clinical trial, endomyocardial biopsies, new mo….
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