The new issue of #ScienceSignaling has arrived! An experimental drug for Parkinson’s disease can reverse the condition’s hallmark effects on neurons in mice, researchers connect a mutant kinase to familial Alzheimer’s disease, and more.

Scientists find that a possible cancer drug target is also an essential guardian of the blood-CNS barrier, a new Review explores research deciphering the mystery of a conserved brake on mTORC1, and more in this week’s issue of #ScienceSignaling.

A new preclinical study identifies a mutant kinase connected to familial #AlzheimersDisease and provides insights about its signaling and abnormal localization that could inform future research into new therapeutics. @RudyTanzi @NewtonLab @UCSDPharm

An experimental drug for genetic #ParkinsonsDisease can prevent the harmful effects of a mutant protein on neurons and cilia, suggesting that early treatment might benefit patients bearing certain disease-linked mutations. @pfeffersuzanne @StanfordDeptMed

Researchers recently identified a molecular hub in neuronal dendrites that shapes the plasticity of synapses and found that the loss of these dendritic scaffolds might play a role in mouse models of #AlzheimersDisease. @Puthanveettil_S @scrippsresearch

New work shows how loss of the calcium-sensing protein STIM2 can worsen outcomes in colorectal cancer and support tumor #metastasis and hint that the protein could be used as a potential prognostic marker. @TrebakM @Trayambak_P @PittDeptofMed

Performing a genome-wide analysis of families afflicted with Alzheimer’s disease, a team identifies a mutant form of the kinase PKC-eta that’s mislocalized at the Golgi apparatus and starkly disrupts the behavior of cells. @RudyTanzi @NewtonLab @UCSDPharm

The experimental drug MLi-2 prevents the deleterious effect of LRRK2 mutations in young mice by restoring both ciliogenesis in striatal neurons and astrocytes as well as Hedgehog signaling, supporting its potential in Parkinson’s disease. @StanfordDeptMed

RT @RudyTanzi: Congrats to all co-authors on our new paper in Science Signaling identifying a new Alzheimer's gene; PRKCH with missense mut….

In this issue, researchers identify a molecular hub in neuronal dendrites that shapes the plasticity of synapses and find that the loss of these dendritic scaffolds might play a role in mouse models of #AlzheimersDisease. @Puthanveettil_S @scrippsresearch

New work shows how loss of the calcium-sensing protein STIM2 can worsen outcomes in colorectal cancer and support tumor #metastasis and hint that the protein could be used as a potential prognostic marker. @TrebakM @Trayambak_P @PittDeptofMed

In our Editors’ Choice piece, we highlight a study by Calhoon and colleagues in @Nature, showing that glycosaminoglycans enable cancer cells to take up antiferroptotic lipoproteins. Read a summary:

A team finds that the #chemokine CXCL12 can support the production of #RedBloodCells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. @stevenduke @GutjahrJulia @QMULWHRI

Researchers have identified a protein that supports inflammation and pain sensitivity in #NeuropathicPain by activating a wide array of metabolic and epigenetic factors and could offer a promising target for pain relief. @ZJU_China

Dendritic scaffolds shape synaptic plasticity through complexes centered on the #lncRNA Gas5, which acts as a “glue” that interacts with various RNAs to support long-term potentiation, according to new work. @Puthanveettil_S @scrippsresearch

Loss of the calcium sensor #STIM2, but not of STIM1, worsens #ColorectalCancer growth and metastasis by boosting calcium ion content in the endoplasmic reticulum, remodeling mitochondria, and rewiring transcriptional activity. @TrebakM @Trayambak_P

Don’t miss this week’s new issue of #ScienceSignaling! New research shows how the loss of a calcium-sensing protein can exacerbate colorectal cancer growth, a preclinical study identifies dendritic scaffolds that shape the plasticity of synapses, and more.

A team finds that the #chemokine CXCL12 can support the production of #RedBloodCells in mice, suggesting that this pathway could be investigated for the treatment of disorders related to red blood cells. @stevenduke @GutjahrJulia @QMULWHRI

Researchers have identified a protein that supports inflammation and pain sensitivity in #NeuropathicPain by activating a wide array of metabolic and epigenetic factors and could offer a promising target for pain relief. @ZJU_China

New discoveries are reshaping how scientists understand the molecular connections between the extracellular matrix (#ECM) and lysosomes—and the resulting implications for research and therapeutics for #neurodegenerative disorders.