Daniel Lucas Kerr
@DanielLucasKerr
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(: MD/PhD student @UW_MSTP. Former šā±California duuudeāļøš at UC San Francisco/UC Berkeley.
Joined July 2020
RT @SRsrivatsan: Today out in @biorxivpreprint we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial geā¦.
biorxiv.org
Spatial genomic technologies include imaging- and sequencing-based methods ( [1][1]ā[3][2] ). An emerging subcategory of sequencing-based methods relies on a surface coated with coordinate-associated...
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RT @collin_blakely: Pleased to report the results of our clinical trial: Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermaā¦.
ascopubs.org
PURPOSETo assess the safety and efficacy of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib as neoadjuvant therapy in patients with surgically...
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RT @DrPhilippeGui: Very proud to have this work finally out in @NatureGenetics! This was a wonderful team effort; I would like to thank Manā¦.
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RT @drmcaswell: I am excited to announce the publication of our manuscript out today, with @DrPhilippeGui, @CharlesSwanton, @SwantonLab, @Bā¦.
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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RT @BivonaLabUCSF: Our latest paper is out now in @NatureGenetics! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancā¦.
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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RT @hojong_yoon: A groundbreaking work from Revolution Medicine - molecular glues that disrupt native PPIs in KRas signaling. Indeed this iā¦.
science.org
Small molecules recruit cyclophilin A to the active state of mutant KRAS to disrupt oncogenic signaling and tumor growth.
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RT @DrTurja: Check out our abstract and poster EP08.02-217 Grateful for my mentor @collin_blakely , teammates @DanielLucasKerr and advocateā¦.
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RT @DrWilliamHwang: Our study on single-nucleus and spatial profiling of pancreatic cancer was published today @NatureGenet and will be theā¦.
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RT @Tadashi_Manabe: I am highly honored to have been selected for this prestigious grant by the @DamonRunyon . For me, this is truly a careā¦.
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RT @NoronhaAshish: Excited to share how #cancer cells can reprogram the resistance mechanisms similar to that of #bacteria. .
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RT @UW_MSTP: Join us in welcoming our incoming class of 2022! šš. #mstp #mdphd #doubledocs #uw #universityofwashington .
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RT @sudhamsuj: I am thrilled to share our recent publication in @Nature, on the Structure of the SHOC2:PP1C:RAS complex, unraveling a lingeā¦.
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RT @drmcaswell: Please checkout the updated version of our preprint, a result of a great collaboration with ā¦@BivonaLabUCSF @HarrisLabUMN wā¦.
biorxiv.org
Apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzymes are cytidine deaminases that play an important role in intrinsic responses to infection by viruses where they inhibit infection...
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RT @jaybradner: Making a splash on the cover of @CD_AACR ā a characterization of our structurally novel, experimental covalent KRASG12C inhā¦.
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RT @BivonaLabUCSF: Fun day of hiking at the Bivona Lab! Good luck to @3doralb and @DanielLucasKerr for the next step in their promising carā¦.
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RT @gerlach_d: Adagrasib in NonāSmall-Cell Lung Cancer Harboring a KRASG12C Mutation | NEJM
nejm.org
Adagrasib, a KRASG12C inhibitor, irreversibly and selectively binds KRASG12C, locking it in its inactive state. Adagrasib showed clinical activity and had an acceptable adverse-event profile in the...
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RT @SmallGTPases: ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1.
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RT @BivonaLabUCSF: Please read our latest work from @Shigeki04860554 out now in @jclinicalinvest: Inactivating genetic alteration of mRNAā¦.
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RT @czbiohub: Out today in @ScienceMagazine, the Tabula Sapiens is 1 of 4 new open-access cross-tissue human cell atlases. This is a majorā¦.
science.org
Single-cell transcriptomics provides a molecularly defined phenotypic reference of human cell types that spans 24 human tissues and organs.
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RT @simanshu: Our latest manuscript, āStructure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome,āā¦.
biorxiv.org
SHOC2 acts as a strong synthetic lethal interactor with MEK inhibitors in multiple KRAS cancer cell lines. SHOC2 forms a heterotrimeric complex with MRAS and PP1C that is essential for regulating RAF...
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