William L Hwang
@DrWilliamHwang
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Dad | Physician-Scientist @MGHCSB @MGH_RI @broadinstitute | Assistant Professor @HarvardMed | GI Radiation Oncologist @MGHCancerCenter
Boston, MA
Joined August 2020
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Our study on single-nucleus and spatial profiling of pancreatic cancer was published today
@NatureGenet
and will be the cover story in the August issue: .
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Excited to announce that the Hwang lab will officially launch in July 2022 in the Simches Research Bldg on the main campus of MGH as part of the Center for Systems Biology
@MGHCSB
, Dept of Radiation Oncology, and Center for Cancer Research
@MGHCancerCenter
.
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This was a really wonderful and unexpected recognition… I’m thankful for my great team, family, colleagues, collaborators, and patients. And I’m grateful to
@MGHCancerCenter
@MGH_RI
@MGHCSB
for the opportunity to start my lab in a very inspirational and supportive environment.
.
@DrWilliamHwang
has been named part of the Lynx Group's 40 Under 40 in Cancer!
The award recognizes individuals' contributions to the field of cancer by "rising stars and emerging leaders under the age of 40 years."
@BeckersHR
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Our single-cell spatial transcriptomics study examining therapy-associated remodeling of cell-cell interactions in pancreatic cancer led by
#CarinaShiau
#JingyiCao
now👉bioRxiv: . This was a close collaboration with
@m_hemberg
@davetingmgh
@nanostringtech
.
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29
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Thanks for the beautiful 📸
@FujifilmUS
@kochinstitute
. Our lab (and my son) will put it to good use! Appreciate everyone who voted for the People’s Choice Award. Grateful to
@BWFUND
@theNCI
@lustgartenfdn
@CureNETs
🙏
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1
100
Thank you
@MGHCancerCenter
, my awesome team, and super supportive mentors
@LabJacks
and Aviv Regev!
Congratulations to
@DrWilliamHwang
for being named an
@AACR
2022 NextGen Star! Dr. Hwang will present his research on
#pancreaticcancer
at the AACR Annual Meeting on 4/11.
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Thank you
@Nature
for featuring our lab's
#CancerNeuroscience
image on the front page of this week! Good timing for the upcoming
#CancerNeuroscienceSymposium
@MDAndersonNews
being held February 28-March 1, 2024 👉
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Our molecular taxonomy of
#PancreaticCancer
now posted! Collaboration b/w
@BroadInstitute
@MassGeneralNews
to develop single-nucleus & spatial transcriptomics improves outcome prediction and provides new insights into mechanisms of therapy resistance.
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Exciting to see our image unveiled at
#KIimages
ceremony! Honored to share this moment w/
@LabJacks
@jennifer3su
@gojimmyguo
@GongDennis
#NLester
#PWang
@MGHCSB
@MGH_RI
@kochinstitute
@broadinstitute
@MGHCancerCenter
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4
76
Unveiling of the
#MGHRadOnc
@MGHCSB
@MGH_RI
@MGHCancerCenter
CosMx Spatial Molecular Imager
@nanostringtech
!
#SarahWeigel
#ErrollRueckert
got some big scissors for the event✂️🎀🔬Thanks for coming
#AnthonyZietman
@tkoolakian
@JenniferWo4
@_sarahwiley
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7
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My son wanted a
@Pokemon
@PokemonTCG
#Pikachu
fresh strawberry cake for his 6th bday so… amateur Dad fondant and baking week became a reality 😂
#KitchenScience
#DadForLife
👨🔬🎂🎁🥳🎈
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1
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Thank you so much for your generous support
@PanCAN
and the
#StarFamily
! We will put this to good use in the fight against
#PancreaticCancer
We're thrilled to award our 2023 PanCAN Career Development Award to William Hwang, MD, PhD (
@DrWilliamHwang
) from Massachusetts General Hospital for his project "Mechanisms of Cancer-Nerve Dynamics in Pancreatic Cancer". This grant is funded by Rick Star in Memory of Janet Ranta…
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I want to express my deepest gratitude to
@gojimmyguo
, an incredible
#MDPhD
trainee
@BBS_Harvard
@UCSFMedicine
@andrewaguirremd
. Brilliant scientist, but even better friend and leader. Helped immensely to build our team and science since 2019.
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3
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Thank you
@NeuroOnc
@michelle_monje
@humsav
@VarunVenkatara2
for the invitation to speak at
#SNO2022
#EducationDay
. Learned a lot and reconnected with colleagues
@RifRahmanMD
#DianaShi
Quick turnaround now back in Boston to spend the evening with my son 👨👦🥰
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Delighted to see my first technician
@LabJacks
, Hannah Hoffman, in her white coat
@harvardmed
@HarvardMITmdphd
@mit_hst
for the first time! Forever grateful to her and the entire team
@gojimmyguo
@_kjag
Jennifer Payman Zack Grissel Carina
#ProudMoment
#TeamScience
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2
65
Congrats to
@gojimmyguo
on his well-earned
#AACR2023
Scholar-in-Training Award! Celebrated with some good 'ole Southern BBQ
#ProudMentor
#PancreaticCancer
@MGHCSB
@MGH_RI
@kochinstitute
@broadinstitute
@DanaFarber_Hale
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Super proud of my technician
#JenniferSu
for winning the Koch Institute Marlena Felter Bradford Research Travel Award! She’ll be presenting our work on tumor-nerve crosstalk in
#PancreaticCancer
@kochinstitute
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Thank you for the generous support
@BWFUND
! Excited to be in the same class with
#WillFreedPastor
in
@LabJacks
. Congrats to everyone!
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1
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Hard to express how proud I am of
@gojimmyguo
as he successfully defended his PhD today.
@andrewaguirremd
got it right; it isn't his incredible work ethic and brilliance that make him special-it's how he brings people together and makes everyone around him better.
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Fun day in the lab today! First a visit from
@theNCI
#CeferinoObcemea
and we got a nice surprise from
#40under40inCancer
. Grateful to my awesome team; together we will make a big impact in the fight against cancer.
@MGHCSB
@MGH_RI
@MassGeneralNews
@broadinstitute
@kochinstitute
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4
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We had an amazing lab retreat! Celebrated the past year and looked forward to the future together.
@MGHCSB
@MGHCancerCenter
@MGH_RI
@broadinstitute
@kochinstitute
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1
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Our lab had a fantastic time raising awareness for
#PancreaticCancer
at the
@PanCAN
@PanCANBoston
#PurpleStride
walk today!! A big thank you to our team captain
#NicoleLester
for an awesome job organizing our team
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Our lab’s third annual retreat was a blast, highlighted by inspiring talks, fun games, uncanny teamwork, hilarious stories, campfire s’mores, and…
@MGHCSB
@MGHCancerCenter
@MGH_RI
@broadinstitute
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1
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Our single-cell analysis examining treatment-associated remodeling of the pancreatic cancer endothelium led by
#CarinaShiau
was published today
@FrontOncology
: Thanks
@LucaPompella
for the invitation!
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Double conference day
#AACRpan22
#SpatialBiologyUS
@NextGenOmics
with
@gojimmyguo
and
#CarinaShiau
🤩
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A fitting team finale at
#AACR2023
with a beautiful presentation by
@gojimmyguo
on key TF, context dependence and therapeutic response of the neural-like
#PancreaticCancer
cell state
@andrewaguirremd
@MGHCSB
@broadinstitute
@kochinstitute
@LabJacks
Photo credit:
@propriodon
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Thrilled to officially welcome
@PiN_Harvard
graduate student
@EllaPerrauIt
to the lab! Welcome Ella 🥳
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The lab presenting posters at the first annual retreat of the newly endowed
#KrantzFamilyCenterforCancerResearch
@MGHCancerCenter
!
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I’m proud to share a beautiful study led by
@gojimmyguo
and Hannah Hoffman, two amazingly talented trainees I have had the privilege to work with over the past two years
@kochinstitute
@MassGeneralNews
@broadinstitute
.
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Thanks so much for having me
@PeterMKWestcott
@CSHL
! I have learned so much from you over the years and I’m looking forward to more future collaborations. I now know where you go to get extra inspiration… that unbelievable office 🌅🤩
It was a great privilege to host the brilliant
@DrWilliamHwang
at our Defeating Cancer seminar series
@CSHL
! Thanks for an excellent seminar on innovative approaches to understanding tumor heterogeneity in
#PDAC
and compelling data on the active role of nerves in driving disease.
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Beautiful talk by
#WillFreedPastor
from
@LabJacks
on
@SU2C
collaboration focused on leveraging organoid-T cell cocultures to improve cell-based therapy in
#PancreaticCancer
.
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Really enjoyed collaborating with
@gojimmyguo
, Hannah Hoffman, David Ting, Colin Weekes, and Lei Zheng on discussing recent single-cell and spatial efforts to refine the molecular framework for pancreatic cancer
@MGHCancerCenter
@hopkinskimmel
@CCR_AACR
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Our pan-cancer DNA repair and immune checkpoint blockade (ICB) study is now out in Cancer Genetics. Led by close friends and collaborators
@gojimmyguo
and
@BrandonMahal
, both incredibly brilliant and prolific, and awesome team
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7
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My amazing technician, Jennifer Su
@LabJacks
, decided it would be most efficient to start a timed protocol at 3 AM yesterday. This is what I walked into this morning. Made my day🤣
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Live from
#AACR22
,
@danielzhang_1
giving a fantastic talk on his work with
@PeterMKWestcott
@LabJacks
on an elegant split-Cre system for highly cell-type specific interrogation of driver genes in
#CRC
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Thank you
@everettmoding
@StanfordRadOnc
for inviting me to share our work! Looking forward to your talk
@MGHCancerCenter
#RadiationBiologyResearchProgram
on February 26
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Great work contributed by
@propriodon
and other lab members to the just published
#CancerNeuroscience
🦀🧠book by
@SpringerNature
#MoranAmit
@nicole_scheff
check it out 👉
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This month, we're excited to extend a warm welcome to three new lab members: Leou Ismael Banla, a resident physician/research fellow; Peter Wang, a postdoctoral research fellow; and Nicole Lester, a research technician!🙌🥳🥂
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I've never felt more like a PI than when I received an email from an awesome admin with unsolicited click-by-click instructions on what I need to do...and I'm not the least bit offended she doesn't think I can figure this out myself because she's 100% correct🤣
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Amazing gathering of cancer neuroscientists and inspiring talks at
#CancerNeuroscienceSymposium
this week.
@propriodon
@EllaPerrauIt
#NicoleLester
represented the lab brilliantly. Thanks to
#MoranAmit
#BrandiMattson
and team for inviting me; it was really fun to plan together.
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Thrilled to annouce that Carina Shiau won
@MGH_RI
Celebration of Science 2022 Poster of Distinction Award for her work in spatial transcriptomics of
#PancreaticCancer
. Huge team effort
@LabJacks
@broadinstitute
@kochinstitute
@gojimmyguo
@_kjag
#JenniferSu
#HannahHoffman
.🎆🥳👏
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Thanks so much for hosting me
@itsTaps
@TAMU_Biology
! I had a wonderful time meeting your faculty and trainees.
Will is visiting us on March 5th
@DrWilliamHwang
@TAMUArtSci
@TAMU_Biology
@nanostringtech
@SpatialBiology
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Honored that
@CCR_AACR
is featuring work led by
@gojimmyguo
and Hannah Hoffman on the cover of May 2021 issue. Thanks to everyone who helped with this fun project!
@MGH_RI
@MGHCancerCenter
@kochinstitute
2
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Words cannot adequately describe the loss of
#JayLoeffler
. A brilliant pioneer and magnanimous leader, but an even greater person, father, husband, role model and mentor. Jay exudes a familial love and devotion to his mentees as does his amazing wife
@Nancyjanemd
.
It is with great sadness to let you know that Jay Loeffler, MD, former Chief of
#radonc
@MGHCancerCenter
passed away 😢
He was a clinical innovator and leader, having pioneered the use of linacs for intracranial SRS
I am forever indebted to him for hiring me & starting up my…
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Our lab is having a blast at
#APA2022
.
#JenniferSu
and
#CarinaShiau
gave great presentations on their work 💯👏Proud of how much they have grown as scientists and people over the past year.
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We are now identifying the key regulators, context dependence and therapeutic vulnerabilities of the treatment-resistant cell states we discovered in this study. Stay tuned for more on these stories! Check out our new lab website: .
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Our lab will focus on the high-resolution study of tumor-stroma interactions in gastrointestinal cancers through development and application of techniques in single-cell/spatial biology, multiplexed imaging, and functional screens to patient specimens, organoids, & animal models.
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#CarinaShiau
gave an awesome presentation at
#AACR2023
on wonderful collaboration with
#JingyiCao
in
@m_hemberg
lab and
@nanostringtech
using single-cell spatial transcriptomics to better understand treatment remodeling of
#PDAC
architecture and intercellular interactions🤩
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It's always nice when hidden talents are recognized.
#NicoleLester
, senior research technician, wowed us with this gorgeous Cape gingerbread house, which won first place in the
@MassGeneralNews
#GingerbreadHouseContest
!
#HappyHolidays
from the Hwang lab!!🎄🕎🪩
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This month our lab is excited to welcome two fantastic PhD students who officially joined the group,
@GongDennis
of
@mit_hst
and
#JeannaQiu
of
@BBS_Harvard
co-advised by
@m_hemberg
. We are also hosting a visiting
@CornellBME
MEng student,
#WillaWei
for the summer!
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Thanks for the invite to give Grand Rounds
#AlanPollack
@BrandonMahal
. Looking forward to future collaborations!!
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The lab is growing! I want to extend a warm welcome to several new members who recently joined or are rotating in the lab this Spring. We can't wait to work with all of you🤩
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I cannot echo this enough
@aparna1024
. My first rotation as a prelim
@MGHMedicine
@mghmedres
was on Big B w/ Hasan. I learned more about being a physician and person from Hasan than any other period in my life.
much to say about today but focusing on a celebration of a legend in medicine. blessed to be a part of the
@MGHMedicine
family “raised” by this one of a kind person - the very best of humans who made us all better. Unveiling of a beautiful portrait that will be forever at
#mgh
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Lab holiday party with some delightful Yankee swap fun and delicious food 🎄🎁🎊
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Please email whwang1
@mgh
.harvard.edu if you are interested in working with us. We have a ton of fun working together on big ideas in spatial/systems oncology and cancer neuroscience. Every team member’s contributions and ideas are valued and recognized. Recruiting at all levels!
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I’m so grateful to work with such a wonderful team of scientists. It is an honor and privilege to be a mentor—a role I do not take for granted and strive to earn each day. Thank you lab for the kind birthday surprise. You guys are truly the best 🙏
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It was a honor co-presenting our work on pancreatic neuroendocrine tumors with rising superstar computational biologist
#CarinaShiau
#NETRF2022
Thank you
@CFerroneMD
@Vik_deshpandeMD
for a great collaboration and
#StevenWang
@gojimmyguo
@jennifer3su
#NicoleLester
#PeterWang
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It’s
#hatday
at my son’s school today and he wanted to wear my alien hat courtesy of Hannah
@gojimmyguo
@DemiSandel
for
@LabJacks
@kochinstitute
retreat. No doubt who wears it better 😂
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We partnered with
@nanostringtech
to perform whole-transcriptome spatial profiling of 21 tumors with matched snRNA-seq; integrating spatial & cellular profiles revealed 3 communities with distinct contributions from malignant, fibroblast and immune subtypes
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Honoring all of our patients and their families on
#WorldPancreaticCancerDay
here at
@pan_association
annual meeting. Thank you
#MinLi
#LeiZheng
for inviting me to share some of our lab's work led by
@propriodon
@EllaPerrauIt
#NicoleLester
#CarinaShiau
#JenniferSu
@RyanZhao
IT'S WORLD PANCREATIC CANCER DAY! 💜📣🎗
Let's turn the world purple today to show support for those facing this disease! Here's how you can join in:
📱Put on your best purple and post on social media! Don't forget to tag
@PanCAN
and
#PanCANawareness
💌 SHARE this post with…
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Dr Larissa Lee was a wonderful physician, person, mentor, and role model to me and so many others. I will miss her greatly but always carry the lessons she taught me about life—always do the right thing for our patients and our children—even if the hurdles seem insurmountable.
A beautiful tribute from
@DrBBychkovsky
about the wonderful Dr Larissa Lee. Larissa was a fantastic person and amazing friend. She was also a gifted physician who helped so many patients. If you’re able, please donate in her memory at the links below.
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Sadly today is the last official day in the lab for
#CarinaShiau
, who along with her experimental counterpart,
@jennifer3su
, both did an incredible job moving our science forward in countless directions. We will miss them but happy they won't be going far away.
1
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Beautiful talk on the less known roles of p53 in cancer development and therapeutic toxicity by
@DKirschMDPhD
as
@HarvardRadOnc
visiting prof!
@MGHCSB
@MGHCancerCenter
@HenningWillers
@TedHong9
@DukeRadOnc
0
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I had a great time discussing our team's research with
@theraltweet
on
@mendelspod
. Thanks for having me on the podcast!
#pancreaticcancer
#spatialbiology
.
@DrWilliamHwang
of Mass General on Discovery of Novel Pancreatic Cancer Cell Subtype
#spatialbiology
#cancer
#singlecellsequencing
@MGHCSB
@MGH_RI
@broadinstitute
@harvardmed
@MGHCancerCenter
0
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Wonderful talk by
@gojimmyguo
at
#AACRPAN21
on comprehensively identifying cell surface therapeutic targets in
#PancreaticCancer
1
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Inspiring talk from Aviv Regev as always! Fantastic science and new ideas to ponder. Grateful to her for being a wonderful mentor.
It was very cool to have Aviv Regev as MGH/MGB Radiation Oncology Grand Rounds Speaker today 🙏🙏🙏
Amazing tour de force through the fascinating (and to me slightly intimidating) world of spatial cancer transcriptomics🔥🔥🔥
But maybe I should let
@DrWilliamHwang
comment☺️🙏
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This summer we are thrilled to have rotating graduate student
@EllaPerrauIt
from
@PiN_Harvard
join the lab! Welcome Ella 🤩🥼
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Postdoc extraordinaire Peter Wang
@propriodon
@MGHCSB
presenting some of our
#CancerNeuroscience
work at
#AACR2023
, abstract 2513, section 6, board 21 from 1:30-5:00 pm.
@kochinstitute
@LabJacks
@broadinstitute
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It's book chapter week for the lab 🤩This time it's
#HannahHoffman
and
@gojimmyguo
with their "Drug Discovery" chapter published in
#TranslationalRadiationOncology
@ElsevierConnect
@AcademicPress
edited by
@DanielKimMD
and team. Great to see this out! 👉
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This refined framework may be helpful in clinical trial stratification and guiding therapeutic targeting of specific cellular phenotypes and multicellular interactions.
1
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A big thank you to
#HongyoonChoi
@snuh_official
#KOGO
for the kind invitation! I enjoyed the wonderful scientific discussions and look forward to collaborating.
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Thanks
@HenningWillers
for the warm welcome! Looking forward to working with you and
@aimeelou
on this important initiative!! ☢️🧫🔬👩🔬
📢Thrilled to have
Aimee McNamara
@aimeelou
&
Will Hwang
@DrWilliamHwang
join as Associate Directors of our
@MGHCancerCenter
#RadBio
Program
🙏🙏🙏
New initiatives including
#radbio
journal club coming soon‼️
➡️
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Fun team-building to start the summer! First synchronized kayaking
@PaddleBoston
taking in beautiful city views, then a spectacular evening of uncanny teamwork at
@golevel99
🧗♂️🛶🏃♀️🧩
1
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Thank you for the invitation to speak
@Adv_Biology
@MDAndersonNews
#MoranAmit
@brandijmattson
. Was fun even though I lost my voice. Spectacular event, hopefully a fixture for years to come!
Dr. William Hwang (
@DrWilliamHwang
) is speaking now at the
#CancerNeuroscience
Symposium. Listen to his talk “Elucidating cancer-intrinsic mechanisms of tumor-nerve crosstalk in pancreatic cancer using spatial transcriptomics!" Click below to join!
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In addition to prior subtypes, our analysis uncovered a neural-like progenitor (NRP) program enriched in brain-associated genes from the Human Protein Atlas and pathways involved in neuronal development/migration, stem-like state, and hepatocyte nuclear factor activity.
1
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Check out this cool video from
@propriodon
and hear more about his work by registering for the 2nd international Cancer Neuroscience Symposium (2/29-3/1/2024)
@MDAndersonNews
. Abstracts in
@Adv_Biology
.
@MGHCSB
@MGH_RI
@broadinstitute
@kochinstitute
1
4
18
Enjoyed chatting
#CancerNeuroscience
and
#SpatialOncology
with
@nicole_scheff
#SahanaLothumalla
on the
#BeyondCancer
podcast in advance of the
#CancerNeuroscienceSymposium
2/28-3/1
@MDAndersonNews
. See y'all in Texas!🤠
1
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Team retreat underway with some great talks from Ananya, Jennifer, Carina, Zack, Diana,
@_kjag
@gojimmyguo
Hannah!
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A big thank you to Prof Lei Zheng, Lucia Treasure, and the entire JHU PMCoE team for inviting me to speak at their monthly seminar series, and for the kind gift from
@hopkinskimmel
🙏
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Grateful to receive a thoughtful care package with
@PanCAN
swag and treats from a superstar high school student doing incredible things for
#PancreaticCancer
awareness, advocacy, and fundraising. The future is bright with kids like this leading the way!🌠
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Elegant work by
@samirzaidi
from
@CharlesSawyers
lab on mechanisms (JAK/STAT, FGFR) of multilineage plasticity towards NE and EMT states in
#CRPC
. Hints of similar plasticity in
#PancreaticCancer
. Common pathways, shared vulnerabilities?
#AACR22
@davetingmgh
@arnavmehta3
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Grateful to John Hopper and the Hopper-Belmont Foundation for supporting our work in
#PancreaticCancer
!
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Thank you
#AGBT22
organizers!
The second session of the day at the 2022
@AGBT
General Meeting brings us
@DrWilliamHwang
from
@MassGeneralNews
detailing how multicellular spatial neighborhoods in pancreatic cancer are remodeled by neoadjuvant treatment.
#AGBT22
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Join the
@PeterMKWestcott
lab! A brilliant scientist and generous mentor (just look at his trainees while in
@LabJacks
), excited to see what is next. Also good for a few Dad jokes 😂
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Please support
@gojimmyguo
at his dissertation defense entitled “Cell states and therapeutic targets in pancreatic cancer” on April 25, 2023 @ 9 AM in TMEC 250 (260 Longwood Avenue).
@DanaFarber_Hale
@MGHCSB
@MGH_RI
@BroadInstitute
@KochInstitute
@LabJacks
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Today is World Pancreatic Cancer Day. Proud to be part of a wonderful team
@KochInstitute
@MGHCancerCenter
@BroadInstitute
working with
@LustgartenFDN
to improve outcomes for our patients. We need everyone to learn your risks, talk to your doctor and wear purple!
#ItsAboutTime
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Excited to join the awesome editorial team at Annals of Pancreatic Cancer. Thanks to Lei Zheng for the opportunity and looking forward to sharing impactful work that will push the field forward for all of our patients.
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To address this shortcoming, we created a high-resolution cellular and spatial atlas of the cellular subtypes that compose pancreatic cancer.
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We optimized single-nucleus RNA-seq for banked frozen patient specimens and profiled 224,988 nuclei across 43 tumors (18 untreated, 25 treated). Representative cell type distributions were captured compared to estimates from multiplexed ion beam imaging
@IonpathOfficial
.
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