Small GTPases
@SmallGTPases
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Small GTPases features research focused on these key signal transducing proteins that are involved in every facet of biology.
Joined December 2015
VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location - Liu - 2024 - Advanced Science - Wiley Online Library
advanced.onlinelibrary.wiley.com
VPS34 plays a crucial role in maintaining mitophagy/autophagy flux during oocyte cytoplasmic maturation and early embryonic development. It exerts its regulatory function by modulating RAB7 activity...
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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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KRas4b–Calmodulin Interaction with Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics | Biochemistry
pubs.acs.org
KRas4b is a small plasma membrane-bound G-protein that regulates signal transduction pathways. The interaction of KRas4b with the plasma membrane is governed by both its basic C-terminus, which is...
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RhoA regulates oligodendrocyte differentiation and myelination by orchestrating cortical and membrane tension. Glia | Neurobiology Journal | Wiley Online Library
onlinelibrary.wiley.com
RhoA negatively regulates developmental CNS myelination. RhoA influences the timing of oligodendrocyte (OL) differentiation. OL differentiation requires fine-tuned cortical and membrane tension....
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ASAP1 and ARF1 regulate myogenic differentiation in rhabdomyosarcoma by modulating TAZ activity
pubmed.ncbi.nlm.nih.gov
Despite aggressive, multimodal therapies, the prognosis of patients with refractory or recurrent rhabdomyosarcoma (RMS) has not improved in four decades. Because RMS resembles skeletal muscle...
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YAP signaling orchestrates the endothelin-1-guided invadopodia formation in high-grade serous ovarian cancer
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Rab2A-mediated Golgi-lipid droplet interactions support very-low-density lipoprotein secretion in hepatocytes | The EMBO Journal
embopress.org
imageimageThe interplay between lipid droplets (LDs) and the Golgi apparatus has been well established, yet their mechanistic details and functional significance remain largely elusive. This study...
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Endosomal Trafficking Bypassed by the RAB5B‐CD109 Interplay Promotes Axonogenesis in KRAS‐Mutant Pancreatic Cancer - Zhang - Advanced Science - Wiley Online Library
advanced.onlinelibrary.wiley.com
This study demonstrates a paracrine mechanism for EVs secretion mediated by Rab5B-CD109 interplay in KRAS-mutant pancreatic cancer, which triggers targeted delivery of circPNIT through CD109+EVs to...
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Overexpression of CDC42 causes accumulation of DNA damage leading to failure of oogenesis in triploid Pacific oyster Crassostrea gigas.
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Motorless transport of microtubules along tubulin, RanGTP, and salt gradients
pubmed.ncbi.nlm.nih.gov
Microtubules are dynamic filaments that assemble spindles for eukaryotic cell division. As the concentration profiles of soluble tubulin and regulatory proteins are non-uniform during spindle...
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CDC42 deficiency leads to endometrial stromal cell senescence in recurrent implantation failure
pubmed.ncbi.nlm.nih.gov
This work was supported by the National Natural Science Foundation of China [82271698 (R.J.), 82030040 (H.S.), 82288102 (H.W.), and 82371680 (G.Y.)]; the Natural Science Foundation of Jiangsu...
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Spatial multiplex analysis of lung cancer reveals that regulatory T cells attenuate KRAS-G12C inhibitor–induced immune responses | Science Advances
science.org
Spatial analysis identified Tregs as a source of local T cell repression, mediating resistance to KRAS-G12C-i and anti–PD-1.
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Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
pubmed.ncbi.nlm.nih.gov
Colorectal cancer tumors start as polyps on the inner lining of the colorectum, in which they are exposed to the mechanics of peristalsis. Our previous work leveraged a custom-built peristalsis...
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In @eLife: Rab11 suppresses neuronal stress signaling by localizing dual leucine zipper kinase to axon terminals for protein turnover
elifesciences.org
Coupling between subcellular localization and protein turnover of a neuronal stress kinase, DLK, and its role in neuronal stress responses in Drosophila.
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A noncanonical GTPase signaling mechanism controls exit from mitosis in budding yeast | PNAS
pnas.org
In the budding yeast Saccharomyces cerevisiae, exit from mitosis is coupled to spindle position to ensure successful genome partitioning between mo...
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Pharmacologic restoration of GTP hydrolysis by mutant RAS
pubmed.ncbi.nlm.nih.gov
Approximately 3.4 million patients worldwide are diagnosed each year with cancers that have pathogenic mutations in one of three RAS proto-oncogenes (KRAS, NRAS and HRAS)1,2. These mutations impair...
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#PLOSONE: Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development.
journals.plos.org
Rabex-5 (also called RabGEF1), a protein originally characterized for its Rab5 GEF function, also has an A20-like E3 ubiquitin ligase domain. We and others reported that Rabex-5 E3 activity promotes...
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MiR‐144/451 attenuates lipopolysaccharide‐induced lung inflammation by downregulating Rac1 and STAT‐3 in macrophages - He - 2024 - Journal of Biochemical and Molecular Toxicology - Wiley Online Library
onlinelibrary.wiley.com
MiR-144/451 gene knockout exaggerated LPS-induced lung inflammation and oxidant stress compared with wild-type mice. The absence of miR-144/451 exacerbates local lung inflammation by targeting Rac1...
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