Hojong Yoon
@hojong_yoon
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Assistant Professor & CPRIT Scholar @MDAndersonNews Interested in Protein degradation, Induced proximity, Small Molecule Drug discovery
Joined December 2014
My lab at @MDAndersonNews is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6).
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RT @kdonovan1008: 📢 Save the Date!.The next FREE Dana-Farber TPD In-Person Event is coming soon!.Join us for an afternoon of cutting-edge s….
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RT @norbertkraut1: #AACR25 Meetings Highlights session:.Thanks to Cory Abate-Shen for summarizing the "fearless chemistry" including degrad….
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RT @davidrliu: A powerful and personal editorial from Nobel laureate @ardemp: "I owe America my success. Today, its scientific future is in….
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RT @jane__huang: Excited to share my graduate work from the @EJohnWherry lab on the molecular mechanisms locking in the differentiation fat….
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A small but meaningful milestone - our lab's first NIH grant NOA! Grateful for the support and excited to get to work!. We're hiring! Candidates with experience in biochemistry, assay development, and structural biology are encouraged to apply!
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Couldn’t recommend more highly!! @biomiko is a great scientist and mentor, as well as one of the niceaset friends I’ve ever met👍.
I am excited to announce the launch of the Slabicki Lab at the Krantz Family Center for Cancer Research within the Mass General Cancer Center and the Cancer Program at the Broad Institute of MIT and Harvard!. đź”— Learn more:
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Very excited for our next seminar next week! Yuh Min Chook(@yuhminchook) at UTSW will share an intriguing allosteric mechanism of drug-induced XPO1 degradation, mediated by the CRL5-ASB8 E3 ligase complex. Join us at 12 pm EST (Feb 20th). Preprint -
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Mind-blowing masterpiece by @brian_b_liau @LabZheng.
Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6
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We have an exciting, unpublished ongoing project, and I’d be happy to discuss the details! Feel free to reach out! (6/6).
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Postdoctoral stipend information can be found here - If you are interested, please send me your CV and short description of your career goals. Also please include contact information of 2-3 references via email (hyoon3@mdanderson.org) (5/6).
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MD Anderson is the #1 cancer center in the US, offering an unmatched research environment and opportunities for rapid clinical translation. Located in Houston, the 4th-largest city in the US, it is known for its affordable cost of living and rich cultural diversity. (4/6).
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We integrate chemical biology, protein biochemistry, medicinal chemistry, functional genomics, and proteomics to redefine druggability. Candidates with experience in chemical biology, protein biochemistry, structural biology, or medicinal chemistry are encouraged to apply. (3/6).
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Our primary research focus is the discovery of novel molecular glues (not chasing CRBN or BRD4 glues!) and elucidating their modes of action at the molecular level, with the ultimate goal of expanding the druggable proteome. (2/6).
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Join us for the final TPD webinar of 2024 on 12/19. @FleurMFerguson & @eswang01 - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC". Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
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Orgchem or biochem folks! How do you manage an enzyme-catalyzed synthesis when your starting material crashes out upon mixing with your protein? . It works well on a small scale, but scaling up becomes tricky. Any tips or tricks?.
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Can't wait!!!.
We are thrilled to have @georg_e_winter @CeMM_News return to the DFCI TPD webinar this Thursday! Georg will talk about how inhibitors can supercharge endogenous degradation mechanisms. Very much looking forward! . 👉Join us at 12 PM EST/ 6 pm CET (hybrid format)
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The journey from drug screening to mechanistic elucidation and its applications is simply remarkable. While it’s reasonable to claim that ACE is a monovalent degrader, I’m not fully convinced whether this compound acts as a molecular glue or induces potential allosteric effects.
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Phenomenal discovery of a Trim21-mediated degrader. ACE shows differential sensitivity across cell lines, requiring reductase activity to reach its functional form.
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RT @norbertkraut1: A must-read! The #DepMap portal is used extensively by the research community to assess gene functions in #cancer, nomin….
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