Bivona Lab
@BivonaLabUCSF
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The Bivona Lab at @UCSF, @UCSFCancer and @czbiohub. Defining signal transduction properties that underlie tumor evolution and therapy response and resistance.
San Francisco, CA
Joined August 2015
Our latest paper is out now in @NatureGenetics! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancer evolution, from tumor initiation to targeted therapy resistance. https://t.co/E5RS66qTEC
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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Join the @BivonaLabUCSF team at #AACR25 Chicago on April 29th! @Tadashi_Manabe 2:30-4:00 PM, Minisymposium Room S102 @YTChou 2:00-5:00 PM, Poster Section 18 Nilanjana Chatterjee 2:00-5:00 PM, Poster Section 17 Stop by to discuss our latest research findings! @UCSFCancer @UCSF
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Dr. Trever Bivona @BivonaLabUCSF presents on the progress of the BAATAAR-UP Center, which focuses on acquired resistance in lung cancer. #ARTNetAnnual
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Pleased to report the results of our clinical trial: Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung #JCO #EGFR
https://t.co/gFT1kM0M9E Thank you to all of the patients who participated.
ascopubs.org
PURPOSETo assess the safety and efficacy of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib as neoadjuvant therapy in patients with surgically...
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Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer | @BivonaLabUCSF @roose_jeroen @UCSF via @NatureComms
pubmed.ncbi.nlm.nih.gov
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung...
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Just out in @NatureComms! Drs. Trever Bivona @BivonaLabUCSF, Jack Roth @JackARothMD and team uncover how the FAK-YAP signaling axis drives drug-tolerant cells and residual disease in lung cancer. #lungcancer #cancerresearch #ARTNetPublication 👇 https://t.co/oHyUl2Jp4p
pubmed.ncbi.nlm.nih.gov
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung...
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Just released on @NatureCancer: "PERCEPTION predicts patient response and resistance to treatment using single-cell transcriptomics of their tumors in myeloma and breast cancer in both pre-clinical and clinical models." Congrats to @BivonaLabUCSF! https://t.co/YVkdwSrgV2
nature.com
Nature Cancer - Sinha and colleagues present PERCEPTION, a precision oncology computational pipeline that can predict the response and resistance of patients by analyzing single-cell transcriptomic...
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Thanks @CD_AACR for highlighting our work showing the complex and context dependant effect of APOBEC3B on lung tumor evolution and targeted cancer therapy resistance!
aacrjournals.org
Major Finding: APOBEC3B inhibits early tumor growth but confers resistance to EGFR-targeted therapy in lung cancer. Concept: EGFR-targeted therapy induces APOBEC3B-associated mutations in genes that...
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In an international collaboration between @bivonaLabUCSF and @HarrisLabUTHSA in the USA and @Drmcaswell @SwantonLab and #DownwardLab at the Crick, researchers found that the mutagenic enzyme APOBEC3B can contribute to targeted cancer therapy resistance https://t.co/0kPBfRjK9w
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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Very proud to have this work finally out in @NatureGenetics! This was a wonderful team effort; I would like to thank Manasi Mayekar and @BivonaLabUCSF. It was a privilege to work with our collaborators @drmcaswell and @CharlesSwanton from @TheCrick!
Our latest paper is out now in @NatureGenetics! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancer evolution, from tumor initiation to targeted therapy resistance. https://t.co/E5RS66qTEC
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I am excited to announce the publication of our manuscript out today, with @DrPhilippeGui, @CharlesSwanton, @SwantonLab, @BivonaLabUCSF, @Downwardlab, and @HarrisLabUTHSA! 🧵 1/15 https://t.co/RfwSDgmXpc
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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This Friday, June 2 @UCSF Cancer Research Seminar | Silvio Gutkind, PhD @UCSDCancer @SilvioGutkind "Exploiting Cancer Signaling Circuitries in the Era of Precision Medicine: Novel Multimodal Targeted and Immunotherapies" Hosted by @BivonaLabUCSF
https://t.co/rAqcGhsN5t
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Finally this preprint! We describe functional ATM deficiency in Ewing sarcoma, a famously chemo-sensitive tumor, and link to native FET protein biology in DNA repair. Led by stellar postdoc @Shruti_menon09, in collab w/ @BivonaLabUCSF @SweetCorderoLab.
biorxiv.org
The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader...
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Excited to learn from all the innovation at #AACR2023 We describe T-cell clonal expansion and tumor neoantigens in lung cancer as a potential clinical frontier - learn more at our poster session! section 21: abstract #605 @BivonaLabUCSF @UCSFHospitals #immunology #CancerResearch
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Saying farewell and wishing the all the best to @TulpuleLab for the next step of his career at @MSKCancerCenter! Looking forward to more great science!
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Check out our abstract and poster EP08.02-217 Grateful for my mentor @collin_blakely , teammates @DanielLucasKerr and advocates @LAGurwitch @IASLC
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Please checkout the updated version of our preprint, a result of a great collaboration with @BivonaLabUCSF @HarrisLabUMN with my mentors @CharlesSwanton and @JulianDownward. Work done @TheCrick @SwantonLab #Downwardlab
biorxiv.org
Apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzymes are cytidine deaminases that play an important role in intrinsic responses to infection by viruses where they inhibit infection...
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