Bivona Lab
@BivonaLabUCSF
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The Bivona Lab at @UCSF, @UCSFCancer and @czbiohub. Defining signal transduction properties that underlie tumor evolution and therapy response and resistance.
San Francisco, CA
Joined August 2015
Our latest paper is out now in @NatureGenetics! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancer evolution, from tumor initiation to targeted therapy resistance.
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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RT @Tadashi_Manabe: Join the @BivonaLabUCSF team at #AACR25 Chicago on April 29th!. @Tadashi_Manabe 2:30-4:00 PM, Minisymposium Room S102….
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RT @NCIARTNet: Dr. Trever Bivona @BivonaLabUCSF presents on the progress of the BAATAAR-UP Center, which focuses on acquired resistance in….
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RT @collin_blakely: Pleased to report the results of our clinical trial: Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epiderma….
ascopubs.org
PURPOSETo assess the safety and efficacy of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor osimertinib as neoadjuvant therapy in patients with surgically...
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RT @UCSFCancer: Focal adhesion kinase-YAP signaling axis drives drug-tolerant persister cells and residual disease in lung cancer | @Bivona….
pubmed.ncbi.nlm.nih.gov
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung...
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RT @NCIARTNet: Just out in @NatureComms! Drs. Trever Bivona @BivonaLabUCSF, Jack Roth @JackARothMD and team uncover how the FAK-YAP signal….
pubmed.ncbi.nlm.nih.gov
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung...
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RT @NCIARTNet: Just released on @NatureCancer:."PERCEPTION predicts patient response and resistance to treatment using single-cell transcri….
nature.com
Nature Cancer - Sinha and colleagues present PERCEPTION, a precision oncology computational pipeline that can predict the response and resistance of patients by analyzing single-cell transcriptomic...
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RT @drmcaswell: Thanks @CD_AACR for highlighting our work showing the complex and context dependant effect of APOBEC3B on lung tumor evolut….
aacrjournals.org
Major Finding: APOBEC3B inhibits early tumor growth but confers resistance to EGFR-targeted therapy in lung cancer. Concept: EGFR-targeted therapy induces APOBEC3B-associated mutations in genes that...
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RT @TheCrick: In an international collaboration between @bivonaLabUCSF and @HarrisLabUTHSA in the USA and @Drmcaswell @SwantonLab and #Down….
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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RT @DrPhilippeGui: Very proud to have this work finally out in @NatureGenetics! This was a wonderful team effort; I would like to thank Man….
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RT @drmcaswell: I am excited to announce the publication of our manuscript out today, with @DrPhilippeGui, @CharlesSwanton, @SwantonLab, @B….
nature.com
Nature Genetics - Analyses of in vivo models, cell lines and patient-derived samples show that apolipoprotein B mRNA-editing catalytic subunit 3B (APOBEC3B) not only restrains lung tumor initiation...
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RT @UCSFCancer: This Friday, June 2 @UCSF Cancer Research Seminar | Silvio Gutkind, PhD @UCSDCancer @SilvioGutkind "Exploiting Cancer Sign….
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RT @TulpuleLab: Finally this preprint! We describe functional ATM deficiency in Ewing sarcoma, a famously chemo-sensitive tumor, and link t….
biorxiv.org
The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader...
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Saying farewell and wishing the all the best to @TulpuleLab for the next step of his career at @MSKCancerCenter! Looking forward to more great science!
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RT @DrTurja: Check out our abstract and poster EP08.02-217 Grateful for my mentor @collin_blakely , teammates @DanielLucasKerr and advocate….
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RT @drmcaswell: Please checkout the updated version of our preprint, a result of a great collaboration with @BivonaLabUCSF @HarrisLabUMN w….
biorxiv.org
Apolipoprotein B mRNA-editing catalytic subunit-like (APOBEC) enzymes are cytidine deaminases that play an important role in intrinsic responses to infection by viruses where they inhibit infection...
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