Craig E Brown
@CraigEdBrown
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Professor at UVic. interested in neuroscience, micro-circulation, hockey. Lab website: https://t.co/mYMRXqmTMS
Victoria, British Columbia
Joined January 2018
Was a pleasure to contribute a little to this new work from Tuan Trang and Yuta Kohro.
molecularbrain.biomedcentral.com
Passage of molecules across the central nervous system is tightly regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB), which restrict entry of many substances, including...
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Main findings: 1) dendritic spines in peri-infarct and ipsi motor cortex most disrupted by stroke but generally recover by 6 wks, 2) ipsi S2 and contra-lateral S1 show minimal changes despite extensive connections, 3) neurons innervating stroke site survive just fine (supp fig).
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Happy to share new paper from MSc grads Myrthe and Jenna. We asked the question, when part of the brain dies during stroke, what happens to local and distant cortical neurons that innervate the stroke site (in S1 cortex) or those that receive outputs? .
journals.sagepub.com
Focal stroke leads to complex neurological disturbances with variable recovery. One explanation for this variability is that stroke disrupts local and remote ne...
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The pathobiology of neurovascular aging: Neuron
cell.com
As the population ages, neurovascular pathologies have become leading causes of death and disability. Santisteban and Iadecola review data showing that neurovascular aging not only reduces cerebral...
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RT @rust_ruslan: Endothelial Response to Blood-Brain Barrier Disruption in the Human Brain | JCI Insight. https://t….
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RT @psapieha: Happy to share our study on the beneficial role of the innate immune system on vascular remodeling in retinal disease and pot….
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RT @MichelleRempel: That Trudeau would expect @cafreeland to deliver the FES after telling her ON FRIDAY he was firing her is peak chauvini….
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RT @RuiBenedito_: iFlpMosaics are now published @naturemethods. A compendium of novel genetic tools and related methods for inducing and a….
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RT @LiGanLab: Excited to share our work, new in @ScienceMagazine: We explored how sex chromosomes, gonadal hormone….
science.org
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex...
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Happy update. In response to losing a day of holiday and 1 night hotel in Paris, @WestJet offered us a $15 food voucher. They really do care!!.
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RT @TheBeaverton: WestJet debuts new slogan: “Air Canada, but somehow worse.”.
thebeaverton.com
CALGARY – WestJet has finally embraced its reputation as one of Canada’s most reviled airlines with the debut of its new company slogan: “Air Canada, but somehow worse.”
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RT @NatureRevEndo: The epidemiology of type 1 diabetes mellitus in older adults #diabetes #T1DM #T1D .
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Congrats to the team! Here we directly image and quantify cerebral #angiogenesis and pruning in vivo. Found interesting regional differences and dependence on #notch signalling. Where you look does matter!
cell.com
The angiogenic capacity of the mature healthy brain and its underlying mechanisms are unclear. Raudales et al. show that rates of cerebral angiogenesis follow regional gradients and are regulated by...
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RT @m_r_williamson: Excited to share our new work out in @Nature !. Learning-Associated Astrocyte Ensembles Regulate Memory Recall. https:/….
nature.com
Nature - A study in mice shows that learning induces c-Fos expression in a subset of astrocytes in the hippocampus, and that ensembles of these learning-associated astrocytes are involved in the...
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Pleased to share our new paper implicating #interleukin 10 in perturbed #brain #microcirculation and #cognitiveimpairment in mouse model of type 1 diabetes. Congrats to the team @uvic, @sharmasorabh88, @UVicMedSciences, @NatMetabolism,
nature.com
Nature Metabolism - Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.
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RT @EricTopol: In diabetes, the capillary microvessels can become obstructed, leading to damage to neurons and cognitive deficits. A new me….
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RT @OsamaHarraz: 📰Excited to share our latest work just published in @NatureComms . Endothelial Piezo1 channel mediates mechano-feedback co….
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Interesting finding since Canadian ethics recommends singly housed rodents be euthanized ASAP…. Effects of single housing on behavior, corticosterone level and body weight in male and female mice | Laboratory Animal Research | Full Text
labanimres.biomedcentral.com
Background Experimental mice are often single-housed either for an individual analysis (feeding behavior, imaging, calorimetry) or as a stress paradigm (social isolation) in translational biomedical...
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