Gan Lab
@LiGanLab
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We've moved to Bluesky! Please follow us there! https://t.co/pbbp33G3QU
New York
Joined July 2019
RT @ISMND1: 🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @naguib_sarah!. Title: Elucidating t….
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The Kolachama Lab is tackling the PET scan bottleneck in Alzheimer’s diagnosis with an AI model that predicts amyloid-β & tau status from 12,185 patients across 7 cohorts, offering a scalable alternative for pre-screening & guiding PET imaging.
nature.com
Nature Communications - A flexible AI framework integrates multimodal neurology work-up data to estimate amyloid and tau burden, supporting scalable biomarker stratification for Alzheimer’s...
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Exciting finding led by Dr. Bruce Yankner: Endogenous lithium is essential for brain health and its deficiency contributes to the onset and progression of Alzheimer’s disease, by activating GSK3β—leading to impaired Aβ clearance and synapse loss.🔗
nature.com
Nature - Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the...
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Using a novel antibody-based mass spec method, this study uncovered >200 UFMylation sites across mouse tissues—including on myosin. Myosin UFMylation is elevated in the skeletal muscle of ALS patients, suggesting unexpected in vivo UFMylation dynamics
cell.com
UFMylation is the post-translational modification of Ubiquitin Fold Modifier1 (UFM1) applied to substrate proteins. Blazev et al. develop an antibody-based enrichment approach followed by LC-MS/MS to...
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Fascinating study from the Hyman, Alberti & Mittal labs reveals the crucial role stress granules play in promoting TDP-43 aggregation through intra-condensate demixing driven by Cys oxidation & hydrophobic patch contacts, opening new doors for therapy.
cell.com
Stress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43...
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And that concludes our chronicles on X! Please follow us on Bluesky🦋:
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Big congratulations to Dr. @CelesteParraB! On Tues., Dr. Parra Bravo defended her thesis with command and grace. Next, she’s headed to a postdoc in the Rosato lab at Dartmouth. We’re so proud of all she’s accomplished and can’t wait to see her continued contributions to science!
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RT @LukensJohnR: Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease: @NeuroCell….
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Congratulations, Dr. Huang!! Gloria defended her thesis today with flying colors. We're so proud of the fantastic science you've done in the past 5.5 years and the energy you brought t lab ❤️🎉
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RT @ChloeLopezLee: Elated to share my PhD work, new in @ScienceMagazine �🏻‍🔬 I was struck by how little we knew abou….
science.org
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex...
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RT @WeillCornell: Inhibiting an immune signaling protein called TLR7 may help preserve the protective layer surrounding nerve fibers in the….
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RT @LukensJohnR: Tlr7 drives sex differences in age- and Alzheimer’s disease–related demyelination | @ScienceMagazine .
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We hope this study inspires further research into how biological sex influences disease mechanisms. Huge congratulations to first author @ChloeLopezLee and thanks to our amazing collaborators @DenaDubal, @LiddelowSA, and all our lab members who made this #scienceresearch possible.
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TLR7 emerged as a pivotal regulator of sex-specific microglial responses. Deleting or inhibiting Tlr7 not only reduced sex differences but also protected against demyelination. These findings pave the way for sex-informed, targeted interventions for neurodegenerative diseases.
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By generating a new FCG mouse model with AD risk factor APOE4 and tau pathology, we revealed that tau-induced interferon response and myelin loss are sex-dependent. These findings add new depth to our understanding of sex-biased progression in AD.
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Using the Four Core Genotype mouse (FCG) model, we uncovered how sex chromosomes and gonads regulate responses across 🧠cell types during demyelination. Together, these cell type-specific effects produced sex differences in neuroinflammation and myelin loss.
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