Jon Brestoff
@BrestoffLab
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Associate Professor MD/PhD @WashuMedicine studying #immunometabolism and #mitochondria transfer in metabolic diseases like #obesity #diabetes and #LeighSyndrome
St Louis, MO
Joined July 2019
Curious about #mitochondria transfer? Check out our latest #MitoTransfer review with the @theHumanBorch in @Nature Feel free to post your thoughts, ideas, and questions below. Please RT to help grow this blossoming field. https://t.co/8sRQlKPpR9
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Proud to announce Dr Stella Varnum! Her defense today was flawless. She is the first PhD student to graduate from my lab, so it was extra bittersweet today. #proudPI @WUSTLImmuno
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Very excited for tomorrow and for soon-to-be Dr. Stella Varnum!
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Boosting mitochondria number and function to slow cellular aging https://t.co/h9CqQ9f263
https://t.co/ZnbqwAwdQG
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This will be a great conference!
Registration is now open for the 2026 Kern Lipid Conference on “Lipids and Lipoproteins in Cardiometabolic and Neurodegenerative Diseases”. Register now: https://t.co/WiRKBxLH3y
@kimberleydbruce @CreweLab
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New! Online now: Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice https://t.co/fQntSCF4Wg
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Thanks to @trikomes for having me on your show! #mitochondria transfer and #obesity and #inflammation
Another new, mitochondria-centric episode is up on my page now "Mitochondrial Transfer, Obesity & Immune-Metabolism Interactions" with @BrestoffLab. Our cells can send and receive mitochondria between themselves. This may be a way that metabolic status in one tissue can be
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Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D
https://t.co/9NBWQxrRYc
@WashUDeptMed
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#Throwback CONSENSUS STATEMENT | @BrestoffLab, @mitoscientist et al. Recommendations for mitochondria transfer and transplantation nomenclature and characterization https://t.co/Sxu3fDDpTO
nature.com
Nature Metabolism - This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.
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This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
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New organelle found in the Human body. The organelle, which is a form of specialized structure, has been given the name “hemifusome” and may help researchers develop new treatments for disease.
nature.com
Nature Communications - Cryo-ET reveals hemifused vesicles containing a hemifusion diaphragm and an associated proteolipid nanodroplet. These hemifusomes drive intraluminal vesicle biogenesis and...
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https://t.co/U160Usgyoz Neurons transfer mitochondria to cancer cells in a process that promotes metastasis. #MitoTRACER in @Nature by @GreletLab
science.org
Scientists spot mitochondria traveling through “bridges” into nearby cancer cells
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Thank you to the @cure_mito Foundation for making a major gift to my lab @washu_pathology @washumedicine in support of our research on Leigh Syndrome. We will use these incredible resources to advance a new mitochondrial therapy that my lab developed for this fatal disease.
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Many thanks to @Cell_Metabolism for featuring part of my journey in their 20th Anniversary Voices series. It's humbling to share page space with scientists who’ve inspired me along the way. @washumedicine @washu_pathology
#5: "Mitochondria on the Move" https://t.co/ieislqfAcE
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This is one of the most mysterious findings about mitochondria.
Discussion with Gordon Freedman @mitoworld_org on how discovering mitochondria cristae alignment led to ideas around the social lives of mitochondria https://t.co/kkdHjnigof
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Tissue source for #mitochondria #transplantation affects the therapeutic benefit against #obesity and #metabolic #syndrome. https://t.co/EcXTGs0Eib Makes sense given that mitochondria in various tissues and cell types can be massively different.
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It was wonderful to celebrate my greatest mentor, Steve Teitelbaum, and his remarkable career today. He touched the lives of many. In my case, he gave me the opportunity to pursue my wildest ideas. Thank you Steve!
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Mitochondria on the ALL IN podcast @theallinpod Thank you @friedberg for educating us about mitochondria. Covering our MitoBrainMap paper and @BrestoffLab's work on mitochondria transfer. @Jason @chamath @DavidSacks
https://t.co/wopmMJ1eEJ
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I want to thank my friend Arjun for waking me up at 4:25 in. the. morning. to tell me about this. The podcast All In @theallinpod featured our work in @nature on #mitochondria transfer and transplantation. Bet you thought it was about something more pressing. Me too.
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