
Nick Borcherding
@theHumanBorch
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Assistant Professor @wusm_pathology | MD/PhD Pathologist using computers for oncology and immunology | Former Marine Corp Sgt
St Louis, MO
Joined November 2019
Amazing resource: 2 million T cells from 70 studies, 1017 biological samples, 583 individuals, and 46 disease conditions https://t.co/5mPPIN9WDf
nature.com
Cell Discovery - A pan-disease and population-level single-cell TCRαβ repertoire reference
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If you are working in the space of HLA/MHC and viral infection or vaccination - please see the special issue from Viruses. If you are interested, please reach out!! https://t.co/3FTtd6dhIa
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Congratulations Dr. Hogg and team @SciImmunology: #dendritic cells can matter in #PancreaticCancer, patients. See it at https://t.co/H1qM3Sx9Vy Big thanks to Swim Across America @SAA_Inc St. Louis and Pedal the Cause @pedalthecause for supporting this research and trial.
science.org
Flt3L and CD40 agonism enhance dendritic cell immunosurveillance in human and murine pancreatic cancer and engage type I immunity.
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TCR2HLA: calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes https://t.co/fXNkiiApgl
#biorxiv_immuno
biorxiv.org
T cell receptors (TCRs) recognize peptides presented by polymorphic human leukocyte antigen (HLA) molecules, but HLA genotype data are often missing from TCR repertoire sequencing studies. To address...
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Researching at the intersection of HLA and viral infections - check out the special issue from Viruses. https://t.co/3FTtd6cJSC
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scRepertoire now supports exporting clones directly into the immunarch workflow @immunomind. Immune cells crosstalk, why not R packages? Vignette: https://t.co/9EvDtNntP8
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dandelionR: Single-cell immune repertoire trajectory analysis in R is out! https://t.co/CwZt0hZ45k Checkout our package at https://t.co/DUHdzq0V7P and on Bioconductor 3.21 onwards! Thanks to everyone involved! @theHumanBorch
github.com
Single-cell immune repertoire trajectory analysis in R - tuonglab/dandelionR
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Offering a wide variety (and growing) methods for analyzing B and T cell immune repertoires - even simultaneously.
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With the ability to process 1 million single-cell clones in < 20 seconds. scRepertoire has been rebuilt from the ground up with C++ integration.
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1st paper out as the senior author, fittingly it is the revamped scRepertoire: building a more comprehensive and efficient single-cell immune profiling ecosystem!! Large thanks to my co-authors @KelvinTuong and others Paper: https://t.co/uXI6vEam4W Repo: https://t.co/WUNyJfDayz
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Can a cancer exploit its environment and still resist treatment? Yes, through co-existing malignant subclones! Let me walk you through our latest study on how divergent evolution drives aggressiveness, and drug resistance of T cell cancer. 1/🧵 https://t.co/KJXwb02uJQ
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Delighted to share our recently published work in @NatImmunol. We show here that normalized microbial exposures in mice enhance memory T cell surveillance of the brain and modify seizure outcomes.
nature.com
Nature Immunology - Harty and colleagues report that physiological microbial exposures in mice can enhance memory T cell presence in the brain and influence neurological disease outcomes.
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Nitin Karandikar, MD, PhD, has been named the enterprise chief strategy officer for University of Iowa Health Care, expanding his executive leadership responsibilities while he continues as professor and chair of the Department of Pathology. https://t.co/jn7rFIxip7...
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1/15 Want to decode pathway activity in single cells? Understand ssGSEA, GSVA, AUCell, and UCell—tools that score gene sets per cell. Here's how they work 🧵
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Wait tell they see your new paper!! @theallinpod thanks for the shout out!!
I want to thank my friend Arjun for waking me up at 4:25 in. the. morning. to tell me about this. The podcast All In @theallinpod featured our work in @nature on #mitochondria transfer and transplantation. Bet you thought it was about something more pressing. Me too.
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Incredible, neither data nor code nor weights are being made publicly available. @Nature publishes advertisements as Articles now I guess.
We’re excited to announce two @Nature publications from Project AMIE (Articulate Medical Intelligence Explorer), a research AI system optimized for diagnostic reasoning and conversations 💬 Paper 1: https://t.co/SqFPdNEbxD Paper 2: https://t.co/KuZgkD8tHl
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Happy #MatchDay to our new @washu_pathology residents! We’re all excited and eager to work with you!
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Attention T cell biologists! New required reading from the one and only @golnaz_v on how the epigenome directs T cell fate and function. https://t.co/CxEdT9qRY5
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scRepertoire now has a function to remove TCR/BCR VDJ genes from the variable features used for dimensional reduction. Friends don't let friends bias their clusters with indirect measures of clonal expansion. https://t.co/R15RhqxH2f
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Feature selection methods affect the performance of scRNA-seq data integration and querying❤️
nature.com
Nature Methods - This Registered Report presents a benchmarking study evaluating the impact of feature selection on scRNA-seq integration.
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