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Nick Borcherding Profile
Nick Borcherding

@theHumanBorch

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Following
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Assistant Professor @wusm_pathology | MD/PhD Pathologist using computers for oncology and immunology | Former Marine Corp Sgt

St Louis, MO
Joined November 2019
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@theHumanBorch
Nick Borcherding
3 days
Amazing resource: 2 million T cells from 70 studies, 1017 biological samples, 583 individuals, and 46 disease conditions https://t.co/5mPPIN9WDf
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nature.com
Cell Discovery - A pan-disease and population-level single-cell TCRαβ repertoire reference
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@theHumanBorch
Nick Borcherding
17 days
If you are working in the space of HLA/MHC and viral infection or vaccination - please see the special issue from Viruses. If you are interested, please reach out!! https://t.co/3FTtd6dhIa
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@DeNardoLabWUSM
David DeNardo WUSM
2 months
Congratulations Dr. Hogg and team @SciImmunology: #dendritic cells can matter in #PancreaticCancer, patients. See it at https://t.co/H1qM3Sx9Vy Big thanks to Swim Across America @SAA_Inc St. Louis and Pedal the Cause @pedalthecause for supporting this research and trial.
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science.org
Flt3L and CD40 agonism enhance dendritic cell immunosurveillance in human and murine pancreatic cancer and engage type I immunity.
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@theHumanBorch
Nick Borcherding
3 months
Researching at the intersection of HLA and viral infections - check out the special issue from Viruses. https://t.co/3FTtd6cJSC
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@theHumanBorch
Nick Borcherding
3 months
scRepertoire now supports exporting clones directly into the immunarch workflow @immunomind. Immune cells crosstalk, why not R packages? Vignette: https://t.co/9EvDtNntP8
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@KelvinTuong
KelvinTuong
4 months
dandelionR: Single-cell immune repertoire trajectory analysis in R is out! https://t.co/CwZt0hZ45k Checkout our package at https://t.co/DUHdzq0V7P and on Bioconductor 3.21 onwards! Thanks to everyone involved! @theHumanBorch
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github.com
Single-cell immune repertoire trajectory analysis in R - tuonglab/dandelionR
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@theHumanBorch
Nick Borcherding
4 months
Offering a wide variety (and growing) methods for analyzing B and T cell immune repertoires - even simultaneously.
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@theHumanBorch
Nick Borcherding
4 months
With the ability to process 1 million single-cell clones in < 20 seconds. scRepertoire has been rebuilt from the ground up with C++ integration.
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@theHumanBorch
Nick Borcherding
4 months
1st paper out as the senior author, fittingly it is the revamped scRepertoire: building a more comprehensive and efficient single-cell immune profiling ecosystem!! Large thanks to my co-authors @KelvinTuong and others Paper: https://t.co/uXI6vEam4W Repo: https://t.co/WUNyJfDayz
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@TerkildB
Terkild Brink Buus
4 months
Can a cancer exploit its environment and still resist treatment? Yes, through co-existing malignant subclones! Let me walk you through our latest study on how divergent evolution drives aggressiveness, and drug resistance of T cell cancer. 1/🧵 https://t.co/KJXwb02uJQ
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@Mix_Maddie
Maddie Mix
4 months
Delighted to share our recently published work in @NatImmunol. We show here that normalized microbial exposures in mice enhance memory T cell surveillance of the brain and modify seizure outcomes.
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nature.com
Nature Immunology - Harty and colleagues report that physiological microbial exposures in mice can enhance memory T cell presence in the brain and influence neurological disease outcomes.
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@UIPathology
University of Iowa Pathology
4 months
Nitin Karandikar, MD, PhD, has been named the enterprise chief strategy officer for University of Iowa Health Care, expanding his executive leadership responsibilities while he continues as professor and chair of the Department of Pathology. https://t.co/jn7rFIxip7...
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@tangming2005
Ming "Tommy" Tang
6 months
1/15 Want to decode pathway activity in single cells? Understand ssGSEA, GSVA, AUCell, and UCell—tools that score gene sets per cell. Here's how they work 🧵
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@theHumanBorch
Nick Borcherding
6 months
Wait tell they see your new paper!! @theallinpod thanks for the shout out!!
@BrestoffLab
Jon Brestoff
6 months
I want to thank my friend Arjun for waking me up at 4:25 in. the. morning. to tell me about this. The podcast All In @theallinpod featured our work in @nature on #mitochondria transfer and transplantation. Bet you thought it was about something more pressing. Me too.
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@SashaGusevPosts
Sasha Gusev
6 months
Incredible, neither data nor code nor weights are being made publicly available. @Nature publishes advertisements as Articles now I guess.
@GoogleForHealth
Google for Health
6 months
We’re excited to announce two @Nature publications from Project AMIE (Articulate Medical Intelligence Explorer), a research AI system optimized for diagnostic reasoning and conversations 💬 Paper 1: https://t.co/SqFPdNEbxD Paper 2: https://t.co/KuZgkD8tHl
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@washupathedu
WashU Medicine Pathology & Immunology Education
7 months
Happy #MatchDay to our new @washu_pathology residents! We’re all excited and eager to work with you!
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@EvanWeberPhD
Evan Weber
7 months
Attention T cell biologists! New required reading from the one and only @golnaz_v on how the epigenome directs T cell fate and function. https://t.co/CxEdT9qRY5
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@theHumanBorch
Nick Borcherding
7 months
scRepertoire now has a function to remove TCR/BCR VDJ genes from the variable features used for dimensional reduction. Friends don't let friends bias their clusters with indirect measures of clonal expansion. https://t.co/R15RhqxH2f
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@LukasValihrach
Lukas Valihrach
7 months
Feature selection methods affect the performance of scRNA-seq data integration and querying❤️
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nature.com
Nature Methods - This Registered Report presents a benchmarking study evaluating the impact of feature selection on scRNA-seq integration.
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