Nick Borcherding
@theHumanBorch
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Assistant Professor @wusm_pathology | MD/PhD Pathologist using computers for oncology and immunology | Former Marine Corp Sgt
St Louis, MO
Joined November 2019
Researching at the intersection of HLA and viral infections - check out the special issue from Viruses.
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scRepertoire now supports exporting clones directly into the immunarch workflow @immunomind. Immune cells crosstalk, why not R packages?. Vignette:
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RT @KelvinTuong: dandelionR: Single-cell immune repertoire trajectory analysis in R is out! . Checkout our package….
github.com
Single-cell immune repertoire trajectory analysis in R - tuonglab/dandelionR
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Offering a wide variety (and growing) methods for analyzing B and T cell immune repertoires - even simultaneously.
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With the ability to process 1 million single-cell clones in < 20 seconds. scRepertoire has been rebuilt from the ground up with C++ integration.
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1st paper out as the senior author, fittingly it is the revamped scRepertoire: building a more comprehensive and efficient single-cell immune profiling ecosystem!! Large thanks to my co-authors @KelvinTuong and others. Paper: Repo:
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RT @TerkildB: Can a cancer exploit its environment and still resist treatment?.Yes, through co-existing malignant subclones!. Let me walk y….
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RT @Mix_Maddie: Delighted to share our recently published work in @NatImmunol. We show here that normalized microbial exposures in mice enh….
nature.com
Nature Immunology - Harty and colleagues report that physiological microbial exposures in mice can enhance memory T cell presence in the brain and influence neurological disease outcomes.
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RT @UIPathology: Nitin Karandikar, MD, PhD, has been named the enterprise chief strategy officer for University of Iowa Health Care, expand….
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RT @tangming2005: 1/15 Want to decode pathway activity in single cells?. Understand ssGSEA, GSVA, AUCell, and UCell—tools that score gene s….
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Wait tell they see your new paper!! @theallinpod thanks for the shout out!!.
I want to thank my friend Arjun for waking me up at 4:25 in. the. morning. to tell me about this. The podcast All In @theallinpod featured our work in @nature on #mitochondria transfer and transplantation. Bet you thought it was about something more pressing. Me too.
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RT @SashaGusevPosts: Incredible, neither data nor code nor weights are being made publicly available. @Nature publishes advertisements as A….
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RT @washupathedu: Happy #MatchDay to our new @washu_pathology residents! We’re all excited and eager to work with you! .
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RT @EvanWeberPhD: Attention T cell biologists!. New required reading from the one and only @golnaz_v on how the epigenome directs T cell fa….
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scRepertoire now has a function to remove TCR/BCR VDJ genes from the variable features used for dimensional reduction. Friends don't let friends bias their clusters with indirect measures of clonal expansion.
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RT @LukasValihrach: Feature selection methods affect the performance of scRNA-seq data integration and querying❤️
nature.com
Nature Methods - This Registered Report presents a benchmarking study evaluating the impact of feature selection on scRNA-seq integration.
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RT @tangming2005: My co-first author paper was out. Cancer-specific innate and adaptive immune rewiring drives resistance to PD-1 blockade….
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RT @sschattgen: Excited to announce a call for submissions for a special collection on T cell responses to influenza that I'm guest editing….
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RT @UlrikStervbo: Happy to see the fantastic work by @zazius, @ScottBoydLab and coworkers finally out in @ScienceMagazine. Great demonstrat….
science.org
Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system’s own record of antigen...
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RT @JohnStreicher1: We have our answer, as expected. They’ll end every research program if it doesn’t make them money. Anyone thinking they….
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