Simon Grelet
@GreletLab
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Cancer Innervation and Neurobiology Lab at the Mitchell Cancer Institute University of South Alabama Cell-cell transfers of mitochondria - RNA biology
Mitchell Cancer Institute
Joined March 2024
Mitochondria move thru the body. Free mitochondria can be exported by brown fat cells into the bloodstream. From there, they transit to cells with damaged mtDNA, where they are imported and rescue mitochondrial function. The implications for cancer therapies are profound.
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Holy Soma Batman! You never know what you may find when you cruise our MICrONS Explorer, such as a blood vessel piercing the soma of a neuron! 👀 See this incredible find up close using this shortcut: https://t.co/QkoavsnhtS
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MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....
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MOSAIC large field of view 3D single molecule localization microscopy of mitochondrial outer membranes and nuclear membranes in fixed U2OS cells.
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"I think the classic adage that the prepared mind is necessary to take advantage of the fortuitious circumstances that an individual has is absolutely right." Cell biologist Craig Thompson discusses the role of intuition in making scientific decisions in this #AskAScientist.
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A neuronal growth cone photographed through a microscope. DIC, actin filaments, and microtubules are shown. #CellBiology
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Our work on intercellular transfer of mitochondria and cancer metastasis has been featured in Cancer Discovery, a journal of the American Association for Cancer Research. @AACR 📖 Read it here:
aacrjournals.org
Cancer-associated neurons can transfer their mitochondria to cancer cells, boosting their metabolism and function. Mitochondria might also serve as a measure of risk of metastases. Future therapies...
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G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing:
nature.com
Nature Genetics - This study examines the function of G-quadruplex DNA secondary structures in mammalian promoters, revealing that they represent core promoter elements contributing to gene...
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🧵1/ T cells have deservedly been in the🔦for #cancer #immunotherapy, but other engineered cell therapies are now📈. What mediates NK cell exhaustion remains an important unanswered❓. 📄Link: https://t.co/dQIK4fVkxO I’m so thrilled🥳to share our work out now🚨@Nature
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🎉 NIH-MERIT Award (R37): I have received the NOA for my first R01 grant from the NIH. I am honored that it has been selected for conversion into an R37 MERIT Award, which allows funding for up to seven years! Learn more: https://t.co/rYmQ5E4Xlq
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A mitochondrion with a snippet sliced off so you can see its inside
Peering into mitochondria - gorgeous life patterns! The parallel infolding are "cristae" where respiration and energy transformation happen The purpose of breathing is to bring oxygen to your cristae
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Skeletal muscle stem cell mitochondria are transferred to muscle fibers in response to a hypertrophic stimulus https://t.co/NGSbbBRRPu
academic.oup.com
Abstract. The fusion of skeletal muscle stem cell (MuSC) to myofibers during hypertrophy has exclusively focused on the transfer of the MuSC nucleus, leavi
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Mitochondrial origins of the pressure to sleep | Nature
nature.com
Nature - Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.
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Organelles share the load | Science
science.org
Peroxisome-mitochondria contact sites manage mitochondrial oxidative stress
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Recently published research on cancer cells and nerve cells led by Simon Grelet, Ph.D., is attracting even more attention. The journal Science includes an article titled "Tumors may get supercharged by acquiring powerhouses of nerve cells." https://t.co/OqUqC75W9d
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Thrilled to see our work led by @liuyunho published in @Cancer_Cell featured by Nature Custom Media @Nature
https://t.co/T8cXmMRlSV Huge thanks to @IanLeGuillou for the thoughtful interview, beautifully written piece @aubreybloom @claytonboldt @MDAndersonNews for their support
nature.com
The spatial organization of cancer-associated fibroblasts within tumours helps shape their identity and role in cancer.
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The fireworks in your mind. 🧠✨ This sparkling video shows the neurotransmitter glutamate being released into synapses, made possible by an indicator developed by @abhi_aggarwal1, @PodgorskiLab, and team. #HappyNewYear #NYE
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A constricted mitochondrial morphology formed during respiration | Nature Communications
nature.com
Nature Communications - Singh et al. report a constricted mitochondrial morphology called Ringo that forms during respiration growth in yeast. Inhibition of Ringo formation correlates with...
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🧠⚡ Check out this article about our work on mitochondrial transfers from nerves to cancer cells, recently featured in New Scientist. https://t.co/u74WjYL28P
newscientist.com
Cancer cells can acquire energy-generating structures called mitochondria from nearby nerve cells, which seems to aid their spread, a discovery that could lead to new treatments
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GeneRanger is a web-server application that provides access to processed data about the expression of human genes and proteins across human cell types, tissues, and cell lines from several atlases. https://t.co/g8Z01tx5jO
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