Tarin Bigley
@BigleyLab
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I am a pediatric rheumatologist who studies viral immunology.
Joined February 2022
Shout out to @DipaoloLab @StellaHoft on a great collaboration and new insight into the development of gastric cancer.
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(1/7)Excited to see our latest manuscript in press at @JCI_insight ( https://t.co/b79az7jSt0)! This was a great extension of our continuing multi-institutional, multidisciplinary group to better understand pathogenic CD8 T cells in #axialspondyloarthritis & anterior #uveitis.
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Really proud to share our lab's most recent publication led by former post-doc @kirill_shumilov. Early depletion of the gut microbiota after TBI alters the oligodendrocyte response and the important role T cells play in this process https://t.co/k27MJPNtSL
#TBI @Neurotrauma
jneuroinflammation.biomedcentral.com
White matter injury (WMI) is thought to be a major contributor to long-term cognitive dysfunctions after traumatic brain injury (TBI). This damage occurs partly due to apoptotic death of oligodendr...
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Tobin & @MACattackLab discuss new work from Jeanpierre et al ( https://t.co/84N0XYhVrA) that identifies new germline variants in the gene encoding PTPN2 associated with loss of regulatory function, enhanced JAK/STAT signaling, and early-onset #autoimmunity. https://t.co/y2RmB7gc5V
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Our new paper led by @TihanaTrsan, collaboration with @TheXavierLab, investigating the link between FGFR1OP and Crohn’s disease. Deletion of FGFR1OP, a centrosomal protein, in mouse gut cells disrupts crypt architecture, causing inflammation and fatality
cell.com
Trsan et al. show that deletion of the centrosomal protein FGFR1OP in mouse intestinal cells disrupts crypt architecture, impairs regeneration, and causes inflammation. FGFR1OP is crucial for...
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ICYMI: Explore a panel of ANRF Scholars and Yale School of Medicine alumni delving into arthritis and autoimmune disease treatments. They will cover advanced therapies and future directions in the field.
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Toth et al. @MACattackLab @WUSTLmed report spontaneous and stimulus-driven skin disease in a mouse model associated w/ locally increased Th17 that is partially dependent on IL-22 signaling https://t.co/lYg8m8uRvz
#autoimmunity #immunodeficiency #inflammation
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The Bigley and Paley labs just published our first senior author paper! This turned out to be a really cool collaboration. We used single cell RNA seq to identify the tropism of roseolovirus in vivo, in the thymus. @drmapaley @thatdnaguy @exue85. 👏 https://t.co/kre0X3mzWn
frontiersin.org
IntroductionHerpesviruses, including the roseoloviruses, have been linked to autoimmune disease. The ubiquitous and chronic nature of these infections have m...
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3/ 🇧🇪@isabelle_meyts,🇺🇸@MACattackLab, @BigleyLab, 🇺🇸Carla Davis and Ruchit Rana identified heterozygous mutations (p.C1013S, p.R1058C and p.R1142X) in the C-terminal domain (CTD) of COPA in 6 children from 3 unrelated families with a syndrome of autoinflammation and autoimmunity
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Great to get this interesting report about a phenotypic expansion of IKAROS GOF published. Congrats to Rachel Guess, @LUveitis @JeffBednarski and George Harocopos. https://t.co/TljEv9tqBm
link.springer.com
Journal of Clinical Immunology -
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Congrats to Selket Delafontaine (@S_Delafontaine) and Isabelle Meyts (@IsabelleMeyts) on this great paper detailing how C-terminal domain variants in COPA lead to disease. It was great to collaborate with your group on this project. https://t.co/FeuwgxF2aR
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Congratulations to our @WUPhysicianScientists Drs. Tarin Bigley, Jeffrey Brown & Drew Schwartz who received Young Physician-Scientist Awards from @the_asci! @BigleyLab @WUSTLPeds @WUDeptMedicine
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Tarin M. Bigley, MD, PhD (@BigleyLab), and Drew J. Schwartz, MD, PhD, were among 52 awardees who were honored with @the_asci's 2024 Young Physician-Scientist Awards. Congratulations! https://t.co/28JUDoNQ6G
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Congratulations, @BigleyLab , on receiving a Scientist Development Award from @RheumResearch!!! 🎉🎉 #Rheumatology #Pediatrics #RheumPeds #SLE #Scientist @WUSTLPeds @WashUDPS
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We are thrilled to have been part of a multi-institutional, multidisciplinary group to identify disease-associated T cells in #AnkylosingSpondylitis & Anterior #Uveitis that recognize antigens presented by HLA-B27, published in @Nature. (1/9)
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The WashU calvary have arrived!! #ACR22 #Philly #ChooseWashURheum #Rheumatology
@BigleyLab @drmapaley @LisaZickuhr @ilee_md
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We are thrilled to share that so many Washington University physician-scientists have recently opened their research labs! Read all about their exciting work and help us cheer them on! https://t.co/Jq0w95mba1
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Proud to share our latest work on the role of T cells in protection from classical Klebsiella pneumoniae. Wonderful effort and insights from Dr. Joseph Mackel! https://t.co/dmFxkqFXZT
frontiersin.org
Infections with classical strains of the Gram-negative bacterium Klebsiella pneumoniae pose a significant clinical challenge due to rising antibiotic resista...
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Forty grants were funded within the department in June! Get more details 👇 @Bark_Lab @BigleyLab @Batten_PSDL @SarahGarwoodMD @AndyGlatz @dhunstad17 @CMimiKao @RobertPotterPhD @RebeccaSame @ellen_schill @DiabetesNinja @vesoulislab
https://t.co/UOtCxbfUbi
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