Tihana Trsan
@TihanaTrsan
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Joined January 2021
Super important work from our colleague and friend, Marco Colonna @TheColonnaLab|| Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell
cell.com
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from the intestine in mice, leading to a reduction of regulatory T cells and impaired oral tolerance to antigens. This...
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Excited to share that our work is featured on the cover of the latest issue of Cell Host & Microbe! Check it out! @TheColonnaLab @VinoloM @pewtrusts
#Microbiology #Immunology #CellHostMicrobe
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Loss of ATG7 in microglia impairs UPR, triggers ferroptosis, and weakens amyloid pathology control https://t.co/ktqB6ozwp6, in this work we linked autophagy with UPR and ferroptosis in the microglial response to AD @CaiZhangying @TheColonnaLab 🥳🍻🆗
rupress.org
Microglia contain Aβ plaques in Alzheimer’s disease (AD). In an AD mouse model, microglial Atg7 deletion impaired plaque coverage, increasing Aβ diffusion
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Our new paper in Cell Host & Microbe: Low-fiber diets worsen C. difficile infection by increasing epithelial MHC-II and expanding pathogenic CD4+ IELs. Fiber-derived acetate and FFAR2 boost ILC3 IL-22, suppressing colonic MHC-II and aiding recovery. https://t.co/YRBA7anvOa
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Our work by Fachi et al. @zefachi is out in PNAS! We show how NKp46+ ILC3s boost early gut defense against C. difficile infection by producing GM-CSF to support neutrophils. A potential path to new CDI treatments! https://t.co/eGErtKTImU
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Need a postdoc, want to work in HK, neuroimmunity and microglia? I'd be happy to help you apply for this: https://t.co/EYpYD9hUy8 please help spread the word
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Collaboration with @TheColonnaLab & others, in press at @Dev_Cell: The FGFR1OP gene, implicated in #Crohns, contributes to intestinal barrier function by modulating the actin cytoskeleton in crypt cells. (1/2)
cell.com
Trsan et al. show that deletion of the centrosomal protein FGFR1OP in mouse intestinal cells disrupts crypt architecture, impairs regeneration, and causes inflammation. FGFR1OP is crucial for...
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💡 New this week in @Dev_Cell! Scientists from @TheColonnaLab & @TheXavierLab, led by Dr. Tihana Trsa, investigated the link between #CrohnsDisease and the FGFR1OP gene, which encodes a centrosome protein. #OpenAccess 👇 🔗 https://t.co/KVRT6HydgR
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FGFR1OP in the #centrosome is important in maintaining barrier function of the cells lining the #gut - insight for #Crohnsdisease. Image & research by @TihanaTrsan et al @TheXavierLab @wusm_pathology @TheColonnaLab @harvardmed in @Dev_Cell. Article link @ https://t.co/eszvRBe4AK
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I am very happy that our paper ( https://t.co/r04KAl9Mzx) is just published in @NatureImmunology
nature.com
Nature Immunology - Sestan et al. find a conserved mechanism during systemic viral infection in which γδ T cells produce IFNγ to increase pancreatic insulin secretion, lowering blood...
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Congrats @PatFernRod! Distinct lineages contribute to cDC2 diversity: lymphoid-derived pDC-like and myeloid-derived pre-cDC2 both develop into transcriptionally similar cDC2, crucial for humoral immune responses, and are distinct from pro-DC3 derived DC3. https://t.co/zYfkw6tubM
cell.com
cDC2 and their precursors exhibit heterogeneity, yet the role of ontogeny remains unclear. Rodrigues et al. show that Cd300c labels a bone marrow cDC2 progenitor, which encompasses lymphoid-derived...
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Excited to announce that I will be officially starting my own lab as an assistant professor on Sep 1st, 2023 at The University of Hong Kong, School of Biomedical Sciences @HKUSBS. Thanks to my mentors (phd/postdoc) and others @TheColonnaLab who helped me reach to this point🙏🙏🙏
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