We are thrilled to have been part of a multi-institutional, multidisciplinary group to identify disease-associated T cells in #AnkylosingSpondylitis & Anterior #Uveitis that recognize antigens presented by HLA-B27, published in @Nature. (1/9)

Thank you, @KilianMD, for inviting me to speak at St. Louis University's Rheum Grand Rounds this morning! It's always great to see our neighbors to the East and talk shop! . @WashUMedRheum #Rheumatology

I’m moving to @bluesky!

Excited to share new findings from my #Spondylitis research! Join me & Dr. Barhram Razani in the @CureArthritis Research Spotlight Series on 9/18. We’ll discuss the latest treatment breakthroughs & research. Register today: #PsA #ArthritisResearch

RT @JCI_insight: An enteric start to HLA-B27-associated autoimmune disease? Work from @drmapaley, @XinboYang777 et….

(7/7) As always, we must thank key funders who supported this campaign to better understand and treat #spondylitis and #uveitis: @RheumResearch, @CureArthritis, @NIH_NIAMS, #HHMI. @wustl_rheum @WUDeptMedicine.

(6/7) We think that more in depth TCR profiling will be needed to stratify patients prior to selecting therapies like BCD180.

(5/7) the T cell receptor (TCR) in pathogenic CD8 T cells. We found, however, that pathogenic CD8 T cells can use multiple TRBV gene segments to create their TCR. Therefore, BCD180 would miss these alternative TRBVs and would likely have a more limited efficacy in some patients.

(4/7)activation in the intestine. This reinforces the notion that autoimmunity from HLA-B*27 originates in the gut. Second, an exciting new therapy (BCD180) has emerged to deplete pathogenic CD8 T cells by targeting TRBV9, which was previously thought to be a key part of.

(3/7)First, even though these pathogenic CD8 T cells can recognize the YeiH antigen from intestinal bacteria, we didn't have evidence (yet) that it happened in people. Here, we found at both the mRNA and protein level that pathogenic CD8 T cells contained evidence of an initial.

(2/7)It has been a joy to keep working with @XinboYang777, the labs of Chris Garcia, @GMAGillespie, @paulbassEB, & Wayne Yokoyama, and of course members of my young lab!. We have 2 main takeaways:.

(1/7)Excited to see our latest manuscript in press at @JCI_insight (! This was a great extension of our continuing multi-institutional, multidisciplinary group to better understand pathogenic CD8 T cells in #axialspondyloarthritis & anterior #uveitis.

RT @nytimes: Pharmacy benefit managers act as middlemen overseeing prescriptions for millions of Americans to reduce drug costs. A New York….

RT @BigleyLab: The Bigley and Paley labs just published our first senior author paper! This turned out to be a really cool collaboration. W….

Really enjoyed the invitation to be on Spondycast and talk about where we are for #HLA-B27 research for #axSpA and #Uveitis and where we might be going. Really excited about the possibility of new #Diagnostics and #Therapeutics. @spondylitis.

RT @spondylitis: 🎙Dive into the latest episode of Spondycast, where host Jill Miller & award-winning ocular rheumatologist @drmapaley enlig….

RT @SaligramaLab: "total number of TCRs in a human, supports Mason’s notion that we should #abandon the ‘one-clonotype–one-specificity’ par….

Check out our new lab website: . #Research.

RT @LaceyFeigl: Thank you, @spondylitis, for awarding Dr. Michael Paley with this years ECI Award! We are so proud of the work he does to….

RT @alhkim: Another great year at #ACRKnowledgeBowl! Congratulations to the finalists and fingers crossed our #WashUComplementCommanders ta….

RT @RuthJeanNapier: Another epic SPARTAN #ankylosingspondylitis meeting with @drmapaley and @tejpalgill . check out that @CureArthritis gea….