Rebecca Bertolio
@BertolioR
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Molecular cell biologist with a huge passion for cell mechanics and metabolism | Post Doc in Del Sal’s lab, @UniTrieste and @ICGEB .
Trieste, Italy
Joined March 2019
Never give up 😅
In 1992 Peter Ratcliffe received this rejection letter from Nature. His findings were not "a sufficient advance in our understanding". 27 years later he won the Nobel Prize for the same discovery. Don't lose faith in the things you believe in.
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In 1992 Peter Ratcliffe received this rejection letter from Nature. His findings were not "a sufficient advance in our understanding". 27 years later he won the Nobel Prize for the same discovery. Don't lose faith in the things you believe in.
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Congratulation to all winners of the 36th Pezcoller Symposium! 🧪🏆 Best Poster Lectures, Pezcoller-Begnudelli Awards, Best Abstract Awards and EMBO Poster Prize 🏅🎉 Thank to support of @EACRnews, @AACR, @TheMarkFdn and @EMBO
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3D imaging and nuclear morphology. Through extension of our CODA platform, we integrate 3D imaging with nuclear segmentation to analyze nuclear morphological features in human tissue. More here: https://t.co/woh0USYZvx
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This should be required reading by all graduate students and postdocs | A brief guide to statistical analysis of grouped data in preclinical research
nature.com
Nature Metabolism - Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N...
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Review alert🟡 Tissue-specific properties of type 1 #dendritic cells in #lung cancer: implications for #Immunotherapy
https://t.co/et55jVVHd0
jitc.bmj.com
Checkpoint inhibitors have led to remarkable benefits in non-small cell lung cancer (NSCLC), yet response rates remain below expectations. High-dimensional analysis and mechanistic experiments in...
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Reasoning about molecular features of the metastatic stroma.
jeccr.biomedcentral.com
Background The identification of molecular features characterizing metastatic disease is a critical area of oncology research, as metastatic foci often exhibit distinct biological behaviors compared...
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🚨 New paper alert! 🚨 Excited to share our latest work in Nature Communications spearheaded by brilliant @Omaiques showing how matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory that supports metastasis! 🧵⬇️
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Instead of listing my publications, as the year draws to an end, I want to put pressure on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research
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Thrilled to share our latest collaboration with @villunger & @CeMM_News in print! 🧬 We show how extra centrosomes can drive cell death 💀⚰️. Huge congrats to @dario_rizz, @VincenzaVigo, and the members of both teams!
science.org
Extra centrosomes can kill blood cancer cells by caspase-2-mediated proteolysis of two alternative substrates, BID and MDM2.
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🎉Excited to finally share that our new work (previously @biorxivpreprint) is now online at @Nature! A fantastic team effort with amazing collaborators. You can read the paper by using the following link: https://t.co/pBFuKIzxWq A thread 🧵/1 https://t.co/LPB5TLE05z
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It was great to present the project I am working on and discussing it with these amazing speakers 🤩 @ICGEB @benvenutilab
Exploring Cancer-Immune Cell Interactions. Key Concepts and Methodologies. Enjoying discussions with young scientists and great speakers in beautiful Trieste @ICGEB
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Epigenetic reactivation of transposable elements induces tumor-enriched antigens in glioblastoma but also some in proliferating nontumor cells @NatureGenet @twang5 @AlbertHKimMDPhD @Nakul2234 @leung_holden
https://t.co/FI92Wvg6vO
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1/n 🚨 🧬Our paper on the role of #mitochondria and free radicals in promoting the collapse of #Cancer #micronuclei is out in @ScienceMagazine today. A story led by the brilliant @melodyDiBona it started with a simple question: why do micronuclei rupture? https://t.co/3Bykj3xF6H
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🚨I am thrilled to finally share our new work on cellular senescence and the mechanism driving the senescence associated secretory phenotype (SASP)! 🔍👇 https://t.co/VgKwfXWR1l
nature.com
Nature Communications - The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, the authors show that the...
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Exciting new inroads into human biology and therapy development: Human intestinal organoids with an autologous tissue-resident immune compartment! #Gjorevski #Cabon #IHB @Nature @IHB_Research
https://t.co/x6YWSjl8yp
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Bin2cell reconstructs cells from high resolution Visium HD data | bioRxiv
biorxiv.org
Summary Visium HD by 10X Genomics is the first commercially available platform capable of capturing full scale transcriptomic data paired with a reference morphology image from archived FFPE blocks...
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Pre-cancerous Niche Remodelling Dictates Nascent Tumour Survival https://t.co/D9QKz6pKm1 This is such an important finding that changes our understanding of tumorigenesis, and what cancer cells actually are.
biorxiv.org
Interactions between mutant cells and their environment play a key role in determining cancer susceptibility. However, our understanding of how the pre-cancer microenvironment contributes to early...
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