Michael Totty
@MicTott
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Postdoctoral researcher at @JohnsHopkinsSPH ; Neuroscientist ; Computational Biology. Person who stutters; Opinions are my own
Baltimore, MD
Joined September 2009
I’m excited to share my latest postdoc project with you all! This was a dream team collaboration co-led by Rita Cervera and @SvitlanaBach. We also developed web apps that allow anyone to easily explore the data, found in the GitHub repo below 👇🏻.
github.com
Collaboration between Costa, Martinowich, and Hicks labs investigating basolateral amygdala cell-types across huamn and non-human primate species. - LieberInstitute/BLA_crossSpecies
26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question:. “What is the [primate] amygdala?”. Check out the preprint 👇.
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Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders
nature.com
Molecular Psychiatry - Transcriptomic pathology of neocortical microcircuit cell types across psychiatric disorders
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The most fun image & video creation tool in the world is here. Try it for free in the Grok App.
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RT @tugcettuna: Excited to share our new preprint with @F_Mourao_ and @StephenMaren showing that 8-Hz theta-paced optogenetic stimulation o….
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Beautiful new work from @tugcettuna, @F_Mourao_, and @StephenMaren showing that 8 Hz stimulation of the reuniens entrains mPFC-HPC oscillations and facilitates fear extinction!
biorxiv.org
Background: The nucleus reuniens (RE) is a midline thalamic nucleus interconnecting the medial prefrontal cortex (mPFC) and the hippocampus (HPC), structures known to be involved in aversive memory...
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RT @TJRyan_77: The cost of remembering: engram competition as a flexible mechanism of forgetting. Our new perspective piece in @TrendsNeur….
cell.com
The retention and use of long-term memories is crucial for adaptive behavior. While stable memories help organisms anticipate outcomes, they may become maladaptive if not updated to reflect new...
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RT @lpachter: Here we go again. Another paper showing that putting arrows on UMAPs (RNA velocity) is biological gobbledygook. https://t.co/….
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Stress-Responsive Neuronal Ensembles and β-Adrenergic Signaling in the Basolateral Amygdala Modulate the Infralimbic Cortical Activity and Govern the Delayed Stress-Induced Fear Extinction Deficit
jneurosci.org
Stress is a critical risk factor for the development of psychological disorders, including anxiety and post-traumatic stress disorder. Key brain regions, including the basolateral amygdala (BLA) and...
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RT @MariosGeorgakis: Two weeks ago, I posted about this @CellCellPress paper. As it drew more attention than I'm used to, I wrote a longe….
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RT @NatureNeuro: An integrated single-nucleus and spatial transcriptomics atlas of the human hippocampus.
nature.com
Nature Neuroscience - The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression...
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Enhancing the Efficacy of Exposure Therapy: Translation of Pharmacological Augmentation of Fear Extinction
osf.io
Fear extinction is foundational to exposure therapy and thus studying strategies to optimize fear extinction is relevant for clinical practice. This paper provides a critical review of translational...
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RT @StephenMaren: 🚨New paper🚨 Excited to share this collaborative paper exploring nucleus reuniens correlates of fear conditioning in both….
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Happy to see the last bit of data I collected during my PhD out in publication now! Congrats to @tugcettuna for leading the manuscript, as well as our co-first author Muhammad Badarnee for leading the effort to incorporate fMRI analyses of the human reuniens!.
🚨New paper🚨 Excited to share this collaborative paper exploring nucleus reuniens correlates of fear conditioning in both rats and humans! Congrats @tugcettuna @F_Mourao_ @MicTott Muhammad Badarnee and Moh Milad!!
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Wow, what a thoughtful care package from @cziscience. Excited to join the Faculty Application Bootcamp to prep for the upcoming job cycle!
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RT @biorxiv_bioinfo: Scalable, fast and accurate differential gene expression testing from millions of cells of multiple patients https://t….
biorxiv.org
Since the development of DNA microarrays and later RNA bulk sequencing, testing with statistically independent samples has been the standard method for detecting genes with different transcription...
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RT @JasonSynaptic: Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @Se….
wsj.com
The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.
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RT @KevinH_PhD: “The new policy means that the number of grants that can be funded this year will drop dramatically. And that will decimate….
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RT @doctorveera: New GWAS of stuttering in ~100k cases and 1 million controls. Polikowsky et al. Nat Gen . https://….
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RT @stephaniehicks: Congratulations @kinnaryhshah @MicTott Svitlana Bach & all co-authors! Wonderful collab btw @jhubiostat @JohnsHopkins….
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All the code and data are publicly available, including easy to use Shiny apps that allow anyone to explore the data in their browser. Give it a try!
github.com
spatialdACC project. Contribute to LieberInstitute/spatialdACC development by creating an account on GitHub.
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Check out this awesome new work led by @kinnaryhshah uncovering the molecular landscape of the human dACC using both spatial and snRNA-seq! Kinnary used a wide range of analyses to characterize the dACC, as well as compare it to the dlPFC of the same donors.
so excited to share that our preprint characterizing the dorsal anterior cingulate cortex in post-mortem human brain from @LieberInstitute is out! we integrated matched SRT and snRNA-seq data to investigate agranularity and von Economo neurons.
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